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Speech markers of cognitive impairment in Parkinson's disease

帕金森病认知障碍的言语标记

基本信息

批准号：
10579185
负责人：
Kara Michelle Smith
金额：
$ 18.92万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-04 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579185
关键词：
Acoustics Address Algorithms American Articulation Assessment tool Award Biological Markers Biomedical Engineering Categories Characteristics Classification Clinic Clinical Clinical Trials Cognitive Cognitive Therapy Cognitive deficits Complication Comprehension Data Data Analyses Dementia Detection Development Development Plans Diagnosis Disease Early Diagnosis Foundations Future Goals Grant Impaired cognition Impairment Individual International Knowledge Language Language Disorders Leadership Life Linguistics Location Longitudinal Studies Machine Learning Massachusetts Master of Science Measures Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Modeling Monitor Motor Movement Disorders Nature Nerve Degeneration Neurobehavioral Manifestations Neurobiology Neurologist Neuropsychological Tests Outcome Outcome Measure Outcomes Research Parkinson Disease Parkinson&apos s Dementia Participant Patient Care Patient-Focused Outcomes Patients Performance Pharmaceutical Preparations Physiology Population Positioning Attribute Production Proxy Quality of Care Quality of life Research Research Personnel Resources Role Rural Science Scientist Severities Specialist Speech Speech Acoustics Symptoms Technology Testing Therapeutic Time Training Universities Validation Work Writing career career development clinical movement disorder clinical practice clinical trial recruitment cognitive change cognitive control cognitive function cognitive impairment in Parkinson&apos s cognitive performance cognitive testing common symptom diagnostic tool experience handheld mobile device improved innovation instrument language processing large scale data lexical retrieval machine learning method medical schools mild cognitive impairment mobile computing mortality motor deficit neurobiological mechanism non-demented novel novel therapeutics patient oriented public health relevance response screening signal processing skills smartphone based assessment syntax tool

项目摘要

ABSTRACT Dr. Kara Smith is a Movement Disorders neurologist at the University of Massachusetts Medical School (UMMS) whose goal is to become an independent investigator focused on early cognitive impairment in Parkinson disease (PD). Her long-term goal is to develop speech markers of cognitive impairment in PD. Cognitive impairment occurs in the majority of PD patients, leading to increased mortality and decreased quality of life. The current diagnostic tools are resource-intensive and have limited sensitivity. Treatments are often offered late in the course of cognitive decline and do not provide optimal benefit. Speech markers could improve detection, monitoring and treatment of cognitive impairment in PD. Speech markers could be monitored frequently and remotely via mobile technology, capturing sensitive, quantitative data about cognitive function in the context of patients’ daily life and in response to therapeutics. Dr. Smith’s role as a clinical movement disorders specialist ideally positions her to lead the application of advanced speech and language research to feasible, patient-oriented tools for real-life clinical practice and clinical trials. Dr. Smith has assembled an expert interdisciplinary mentorship team ideally suited for the goals of this innovative proposal. Dr. Smith and her team have previously shown that a) speech acoustic markers are associated with cognitive function in non-demented PD patients, and b) PD patients with mild cognitive impairment had linguistic deficits including pauses within utterances and grammaticality. Building on these results, Dr. Smith proposes to study speech and language more comprehensively in PD patients with and without mild cognitive impairment and controls to confirm these preliminary results and identify additional biomarkers. The aims of this study will be 1) to develop algorithms using speech acoustic markers to categorize by cognitive status, 2) to identify linguistic markers associated with mild cognitive impairment in PD, and 3) to assess on-line syntactic processing in PD subjects with mild cognitive impairment. The overall goal of the proposal is to identify speech and language markers of early cognitive dysfunction that can be further refined, validated and implemented using mobile technology into a larger scale, longitudinal R01 proposal. Further work will also address the underlying neurobiological mechanisms of these speech markers. Dr. Smith’s rigorous training plan includes a Master’s degree, linguistics and speech motor physiology courses, and experience in signal processing and speech acoustic analysis. Through her training goals, she will advance her knowledge and skills in patient-centered outcomes measures and instrument validation. She will gain experience in research leadership, presentation and dissemination of scientific work, and in grant writing, culminating in an R01 proposal. This K23 award will be critical for Dr. Smith to establish an independent career as a PD clinician-scientist at the unique intersection of speech and language science and cognitive impairment.

摘要