Optimizing diabetes technology use for Latinx youth through DREAM (Device use Reimagined through Education And Mentorship) virtual peer groups

通过 DREAM（通过教育和指导重新构想设备使用）虚拟同伴小组，优化拉丁裔青少年的糖尿病技术使用

• 批准号: 10583855
• 负责人: Jennifer K Raymond
• 金额: $ 37.48万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583855
• 关键词: Achievement; Address; Adolescent; Adolescent and Young Adult; Adoption; Attitude; Black race; California; Caring; Childhood; Childhood diabetes; Clinic; Clinical; Clinical Trials; Collaborations; Communities; Complications of Diabetes Mellitus; Data; Development; Device Designs; Devices; Diabetes Mellitus; Doctor of Philosophy; Dreams; Education; Endocrinologist; Ethnic group; Evaluation; Family; Family health status; Feedback; Focus Groups; Geography; Glycosylated hemoglobin A; Goals; Grant; Group Interviews; Happiness; Health; Health Personnel; Insulin; Insulin Infusion Systems; Insulin-Dependent Diabetes Mellitus; Intervention; Interview; Knowledge; Latinx; Latinx population; Lead; Los Angeles; Maintenance; Measures; Medical; Mentorship; Modeling; Outcome; Participant; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pediatric Hospitals; Peer Group; Persons; Phase; Population; Population Heterogeneity; Process Measure; Provider; Psychologist; Public Health; Pump; Quality of life; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Readiness; Reporting; Research; Research Personnel; San Francisco; Structure; System; Technology; Universities; Visit; Work; Youth; acceptability and feasibility; adverse outcome; age group; aged; blood glucose regulation; clinical center; design; diabetes distress; diabetes risk; diabetes self-management; ethnic diversity; experience; feasibility testing; future implementation; glucose monitor; glycemic control; group intervention; health care service utilization; high risk; hospital utilization; improved; medical appointment; member; monitoring device; multidisciplinary; novel; patient engagement; peer; peer support; phase II trial; pilot test; prevent; primary outcome; programs; racial and ethnic; recruit; satisfaction; social; stakeholder perspectives; standard care; telehealth; therapy design; uptake; virtual

PROJECT SUMMARY/ABSTRACT Strict glycemic control is critical for optimal type 1 diabetes (T1D) outcomes but remains challenging for youth from historically marginalized ethnic groups, in whom hemoglobin A1c (A1c) levels are consistently the highest in the nation. In California, Latinx youth are the largest marginalized ethnic group with T1D, but they experience less optimal glycemic control than their White counterparts. Continuous glucose monitoring, insulin pumps, and automated insulin delivery systems can assist with achievement of target A1c levels, but Latinx youth have lower rates of diabetes device use compared to White youth. Virtual peer groups (VPGs) can improve patient engagement and diabetes self-care in Latinx youth, and preliminary data suggest that VPGs may increase the use of diabetes technology in this population. Jenise Wong, MD PhD, and Jennifer Raymond, MD MCR, propose this project grant with the objective to increase the adoption and sustained use of diabetes devices in Latinx adolescents with T1D by engaging them and their families in the development and evaluation of a VPG intervention designed to improve technology use. This project will engage multiple stakeholders (patients, families, health care workers) from three clinic populations in California (Children’s Hospital of Los Angeles, University of California Davis, and University of California San Francisco) and result in the DREAM (Device use Reimagined through Education And Mentorship) program. In collaboration with a multidisciplinary team of pediatric endocrinologists, psychologists, and public health experts, the researchers propose a project with the following aims: (1) partner with stakeholders to adapt a virtual peer group model to promote the initiation and continued use of diabetes technology among Latinx adolescents with T1D, (2) evaluate the feasibility and acceptability of DREAM in a pilot randomized controlled trial, and (3) assess the effect of DREAM on clinical and patient-centered outcomes. These aims will be addressed in a formative phase and a clinical trial phase. In Phase 1, the research team will address Aim 1 by engaging stakeholders in focus groups and semi-structured interviews to obtain qualitative data that will directly inform the design of the DREAM VPGs and the clinical trial. A subset of stakeholders will form Advisory Councils who will provide longitudinal input during the clinical trial. In Phase 2, the research team will conduct a pilot randomized clinical trial of the DREAM intervention in 120 Latinx youth aged 13 to <18 years with T1D, recruited from three pediatric diabetes clinic populations in California. To address Aim 2, the researchers will collect qualitative feedback from focus groups and quantitative data on VPG feasibility, appropriateness, and acceptability as primary outcomes. Preliminary data on clinical outcomes of A1c and hospital utilization, and patient-centered outcomes will be assessed to address Aim 3. The results of this study will result in a novel, culturally appropriate, VPG model to increase use of diabetes technology for Latinx youth with T1D that may be further adapted and disseminated for other age groups, geographic settings, or racial/ethnic populations.

项目摘要/摘要 严格的血糖控制对1型糖尿病(T1D)的最佳结局至关重要，但对年轻人来说仍然具有挑战性 来自历史上被边缘化的种族群体，他们的血红蛋白A1c(A1c)水平一直是最高的 在全国范围内。在加利福尼亚州，拉丁裔青年是患有T1D的最大的边缘化种族群体，但他们 与他们的White同行相比，他们体验到的血糖控制不是很理想。连续血糖监测，胰岛素 泵和自动化胰岛素输送系统可以帮助实现目标A1c水平，但Latinx 与白人青年相比，青年糖尿病设备的使用率较低。虚拟对等组(VPG)可以 改善拉美裔青年的患者参与度和糖尿病自我护理，初步数据表明VPG 可能会增加糖尿病技术在这一人群中的使用。医学博士Jenise Wong和Jennifer 雷蒙德，医学博士，MCR，提出这一项目赠款的目标是增加采用和持续使用 通过让患有T1D的拉美裔青少年及其家人参与糖尿病设备的发育来评估他们的糖尿病设备 以及评估旨在改善技术使用的VPG干预。该项目将涉及多个 来自加州三个诊所人群的利益相关者(患者、家庭、医护人员)(儿童 洛杉矶医院、加州大学戴维斯分校和加州大学旧金山分校)，并导致 梦想(通过教育和指导重新想象设备使用)计划。与 由儿科内分泌学家、心理学家和公共卫生专家组成的多学科团队，研究人员 提出一个具有以下目标的项目：(1)与利益相关者合作，使虚拟对等组模式适应 在患有T1D的拉美裔青少年中促进糖尿病技术的启动和继续使用，(2) 在先导随机对照试验中评估DREAM的可行性和可接受性，以及(3)评估 梦境对临床和以患者为中心的结果的影响。这些目标将以形成性的方式加以解决 阶段和临床试验阶段。在第一阶段，研究团队将通过让利益相关者参与 焦点小组和半结构化访谈，以获得将直接为设计提供信息的定性数据 梦想VPG和临床试验。一部分利益相关者将组成咨询委员会，他们将提供 临床试验期间的纵向输入。在第二阶段，研究小组将进行试点随机临床试验 对120名13-18岁拉丁裔青少年进行梦境干预的试验 加州的儿科糖尿病诊所人口。为了达到目标2，研究人员将收集定性的 来自焦点小组的反馈和关于VPG可行性、适当性和可接受性的量化数据 主要结果。以患者为中心的A1C临床结果和医院利用的初步数据 将对结果进行评估，以实现目标3。这项研究的结果将导致一种新的、文化上的 适当的VPG模式，为患有T1D的Latinx青年增加糖尿病技术的使用，这可能会进一步 改编和传播给其他年龄段、地理环境或种族/民族人口。