Circuit-level neurodevelopmental trajectories of decision-making computations across adolescence
青春期决策计算的电路级神经发育轨迹
基本信息
- 批准号:10582133
- 负责人:
- 金额:$ 68.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-07-30
- 项目状态:未结题
- 来源:
- 关键词:AdolescenceAdolescentAdultAgeAmygdaloid structureAnteriorAttentionBehaviorBrainBrain imagingBrain regionCalciumClinicalComplexComputer ModelsCoupledDataDecision MakingDevelopmentFiberFutureImageIndividualLearningLinkMediatingMental disordersMethodsMidbrain structureNeuronsOutcomePhotometryPopulationPrefrontal CortexProcessProto-Oncogene Proteins c-ablPsychological reinforcementRattusReportingReversal LearningRewardsRoleST5 geneSignal TransductionSynapsesSystemTechniquesTestingUpdateVentral Tegmental AreaViralVirusage relatedawakebasecingulate cortexcritical periodimaging studyimprovedin vivoin vivo calcium imagingin vivo optical imaginginnovationinsightneural circuitneural networkneurodevelopmentoptogeneticsranpirnaserelating to nervous systemtranslational study
项目摘要
Project Summary
Adolescence is one of the most critical periods of neurodevelopment. The brain undergoes a profound
reorganization during this stage, including the formation and stabilization of neural circuits that control decision-
making. We, and others, hypothesize that age-related improvements in decision-making are driven by changes
in brain circuits that encode specific decision-making mechanisms. Direct evidence supporting this hypothesis,
however, has been limited. The prefrontal cortex in particular undergoes an intense restructuring during
adolescence and brain imaging studies have observed robust changes in the orbitofrontal cortex (OFC) and
anterior cingulate cortex (ACC). The OFC and ACC are altered in individuals with mental illness, which is thought
to be the mechanism underlying decision-making deficits that emerge in these clinical populations. When and
how these alterations occur is not known, but emerging evidence suggests developmental changes in subcortical
projections to the OFC and ACC may be involved. Here, we propose to use in vivo calcium imaging and
optogenetic techniques coupled with computational modeling, to longitudinally assess circuit and neuronal
activity in behaving rats at multiple adolescent ages to determine how developmental changes in OFC and ACC
networks mediate improvements in decision-making. In Aim 1 we will determine how encoding of attention and
reward-prediction errors in amygdala and ventral tegmental area (VTA) projections to the OFC improves across
adolescence in rats using a reversal-learning task. We will then use a new transsynaptic tracing approach in Aim
2 to demonstrate that attention and reward prediction errors controlled by amygdala and VTA projections are
integrated into OFC neurons to determine the degree to which action values are updated and strengthened
during adolescence. Finally, Aim 3 studies will investigate the role of OFC projections to the ACC in integrating
value updating with current action value estimates that guide adaptive decision making. Together, these studies
will provide key insights into the developmental mechanisms that guide complex decision making. Our normative
data will provide a framework for identifying and understanding the neurodevelopmental mechanisms of mental
illness, and inspire future translational studies.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephanie Mary Groman其他文献
Stephanie Mary Groman的其他文献
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{{ truncateString('Stephanie Mary Groman', 18)}}的其他基金
Circuit-level neurodevelopmental trajectories of decision-making computations across adolescence
青春期决策计算的电路级神经发育轨迹
- 批准号:
10705252 - 财政年份:2022
- 资助金额:
$ 68.55万 - 项目类别:
Molecular Mechanisms of Susceptibility to Drug Use
吸毒易感性的分子机制
- 批准号:
10316306 - 财政年份:2021
- 资助金额:
$ 68.55万 - 项目类别:
Molecular Mechanisms of Susceptibility to Drug Use
吸毒易感性的分子机制
- 批准号:
10215467 - 财政年份:2021
- 资助金额:
$ 68.55万 - 项目类别:
Molecular Mechanisms of Susceptibility to Drug Use
吸毒易感性的分子机制
- 批准号:
10430189 - 财政年份:2021
- 资助金额:
$ 68.55万 - 项目类别:
Molecular Mechanisms of Susceptibility to Drug Use.
药物使用敏感性的分子机制。
- 批准号:
10936772 - 财政年份:2021
- 资助金额:
$ 68.55万 - 项目类别:
Molecular Mechanisms of Susceptibility to Drug Use
吸毒易感性的分子机制
- 批准号:
10653168 - 财政年份:2021
- 资助金额:
$ 68.55万 - 项目类别:
Molecular mechanisms of susceptibility to drug use
吸毒易感性的分子机制
- 批准号:
10029887 - 财政年份:2020
- 资助金额:
$ 68.55万 - 项目类别:
Identification of a non-invasive neuroimaging biomarker of prenatal synaptic development
产前突触发育的非侵入性神经影像生物标志物的鉴定
- 批准号:
9808337 - 财政年份:2019
- 资助金额:
$ 68.55万 - 项目类别:
Impulsivity and D2 Receptor Function: Behavioral and PET Correlates
冲动性和 D2 受体功能:行为和 PET 相关性
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- 资助金额:
$ 68.55万 - 项目类别:
Impulsivity and D2 Receptor Function: Behavioral and PET Correlates
冲动性和 D2 受体功能:行为和 PET 相关性
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8246495 - 财政年份:2010
- 资助金额:
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