Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects

父本线粒体消除和辐射诱导的旁观者效应的基本机制

• 批准号: 10582377
• 负责人: DING XUE
• 金额: $ 3.3万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582377
• 关键词: Animals; Biochemical; Biological; Biological Process; Bystander Effect; Cell physiology; Cells; Defect; Development; Disease; Ensure; Event; Genes; Human; Impairment; Inherited; Mediating; Mitochondria; Mitochondrial Diseases; Molecular Genetics; Normal Cell; Pathologic; Pathway interactions; Process; Proteomics; Radiation; Radiation therapy; Signal Pathway; Signal Transduction; Stress; Therapeutic; Work; biological adaptation to stress; fitness; human disease; improved; new therapeutic target; novel; response; reverse genetics; side effect; zygote

Summary of R35 GM118188 (Xue, PI) Project title Fundamental mechanisms of paternal mitochondrial elimination and radiation-induced bystander effects Project summary Paternal mitochondrial elimination and radiation-induced bystander effects are two vitally important, distinct, and dynamic biological processes essential for animal development, stress response, and organismal fitness. Defects in these two important processes can cause various pathological conditions and disease. In this proposed work, we will carry out molecular genetic, reverse genetic, biochemical, cell biological and proteomic analyses to decipher basic mechanisms that regulate paternal mitochondrial elimination and radiation-induced bystander effects. For the study of paternal mitochondrial elimination, we hope to understand how paternal mitochondria are selectively impaired, recognized and removed in fertilized eggs, what paternal and maternal mechanisms are employed to specifically eliminate paternal mitochondria, and why paternal mitochondria need to be removed to ensure animal development and cell and organismal fitness. For the study of radiation- induced bystander effects, we plan to identify factors involved in triggering bystander effects in unexposed cells, signal pathways that mediate different bystander responses, and the mechanistic basis of bystander responses to other stresses. These studies should reveal novel mechanisms, pathways, and genes that control these two fundamental biological processes, and ultimately, provide new targets, ideas, and strategies to facilitate treatment of numerous human diseases caused by abnormalities in paternal mitochondrial elimination and improve disease treatment by reducing side effects caused by radiotherapy and other therapeutic treatments.

R35 GM118188概述（薛，PI）