West Virginia University Stroke COBRE

西弗吉尼亚大学卒中防护中心的总体目标是降低与中风相关的发病率和死亡率 通过提高对中风的病理生理机制的认识来认识中风(S)。我们会 通过开展高质量的基础研究和翻译研究来实现这一总体目标 应对可改变的危险因素、生物标志物、机制(S)、预防策略、急性 以及中风的慢性治疗和康复。这一目标将通过实现 以下三个具体目标：具体目标1.扩大资助调查人员的临界数量 开展中风康复研究。在第二阶段，我们建议巩固以下承诺 研究人员对中风的研究，部分是通过提供尖端的中风研究核心设施 和服务(见具体目标2)，生成有意义的初步数据以支持其赠款 通过资助五个初级调查员项目提出申请，提供资助金 举办工作坊/活动，以改善他们的补助金申请，并扩大密集辅导 在西弗吉尼亚州立大学中风科布雷第一阶段启动的计划。具体目标二.加强创新 支持和推进基础和转化性中风研究的科学核心。我们建议 扩大这些重要核心的范围和能力以及用户基础。这将是 通过引入新服务来实现(例如，新的中风模型；其他行为 测试)，并为研究核心提供培训课程。除了实验性中风 核心(ESC)和啮齿动物行为核心(RBC)，这是为Cobre基金提出的，我们 将开发另外两个核心，即线粒体功能评估核心(MFAC)和 中风组织银行。具体目标3.推动正在进行的独立、 可持续的、多学科的中风研究主题计划。实现的目标 WVU Stroke Cobre的独立(独立于Cobre的资金)已经开始，并将继续 第二阶段由用户付费过渡到以研究为基础的核心服务，独立 资助研究补助金，包括对这些核心服务的资助和西弗吉尼亚大学的支持 HSC.在西弗吉尼亚大学卒中科布雷第二阶段结束时，指导培训将有 提供了更多的JIS参与与中风相关的研究。我们将解决 需要对病因、急性和亚急性治疗和 通过(1)增加独立资助的WVU中风的数量来从中风中恢复 研究人员，(2)扩大中风研究的核心服务和用户数量，(3)继续 通过西弗吉尼亚大学以用户为基础的服务筹资模式来维持这些资源的过渡。

The Overall Objective of the WVU Stroke CoBRE is to decrease morbidity and mortality related to stroke through improved understanding of pathophysiological mechanism(s) of stroke. We will accomplish this overall goal by conducting high-quality basic and translational research addressing the modifiable risk factors, biomarkers, mechanism(s), preventative strategies, acute and chronic treatments and rehabilitation of stroke. This objective would be met by achieving the following three Specific Aims: Specific Aim 1. Expand the critical mass of funded investigators conducting stroke recovery research. In Phase II we propose to solidify the commitment of investigators to stroke research, in part, by providing cutting-edge stroke research core facilities and services (See Specific Aim 2), generating meaningful preliminary data in support of their grant applications through funding of five Junior Investigator projects, providing grantsmanship workshops/activities to improve their grant applications, and expanding the intensive mentoring program initiated in Phase I of the WVU Stroke CoBRE. Specific Aim 2. Strengthen innovative scientific cores that support and advance basic and translational stroke research. We propose to expand the scope and capacity, as well as the user-base of these vital cores. This will be accomplished by the introduction of new services (e.g., new stroke models; additional behavioral tests), and provide training sessions for research cores. In addition to the Experimental Stroke Core (ESC) and the Rodent Behavior Core (RBC), which are proposed for CoBRE funding, we will develop two additional cores, the Mitochondrial Functional Assessment Core (MFAC) and the Stroke Tissue Bank. Specific Aim 3. Advance the ongoing development of an independent, sustainable, multidisciplinary thematic program of research on stroke. The goal of achieving independences (of CoBRE funding) of the WVU Stroke CoBRE has begun and will continue in Phase II by the transition to a user-fee based funding of research core services, the independent funding of research grants that include funding for these core services and support from the WVU HSC. At the conclusion of Phase II of the WVU Stroke CoBRE, mentored training will have been provided to engage additional JIs in stroke-related research. We will have addressed the need for basic and translational research into the causes, acute and subacute treatments and recovery from stroke by (1) increasing the number of independently funded WVU stroke researchers, (2) expanding stroke research core services and user numbers, and (3) continuing the transition to sustain these resources through a user-based funding model for services at WVU.