West Virginia University Stroke COBRE

WVU卒中CoBRE的总体目标是降低与卒中相关的发病率和死亡率。 通过提高对中风病理生理机制的认识，我们将 通过开展高质量的基础研究和转化研究来实现这一总体目标 解决可改变的风险因素、生物标志物、机制、预防策略、急性 以及中风的慢性治疗和康复。要实现这一目标， 三个具体目标：具体目标1。扩大获得资助的调查人员的临界数量 进行中风康复研究在第二阶段，我们建议巩固以下承诺： 研究人员中风研究，部分，通过提供先进的中风研究核心设施 和服务（见具体目标2），产生有意义的初步数据，以支持他们的赠款 通过资助五个初级研究员项目， 举办讲习班/活动，以改进其赠款申请，并扩大强化辅导 在WVU Stroke CoBRE的第一阶段启动的计划。具体目标2。加强创新 支持和推进基础和转化中风研究的科学核心。我们建议 扩大这些重要核心的范围和能力以及用户基础。这将是 通过引入新服务（例如，新的中风模型;额外的行为 测试），并为研究核心提供培训课程。除了实验性中风 核心（ESC）和啮齿动物行为核心（RBC），这是建议为COBRE资金，我们 将开发另外两个核心，线粒体功能评估核心（MFAC）和 中风组织库。具体目标3。推动正在进行的独立、 可持续的、多学科的中风研究专题计划。最终达到 WVU Stroke CoBRE的独立性（CoBRE资金）已经开始，并将继续在 第二阶段由过渡到以使用者付费为基础的研究核心服务经费， 资助研究赠款金，包括这些核心服务的资金和西弗吉尼亚大学的支持 HSC。在WVU Stroke CoBRE的第二阶段结束时，指导培训将 在中风相关的研究中提供额外的JI。我们将解决 需要对病因、急性和亚急性治疗进行基础和转化研究， 通过（1）增加独立资助的WVU卒中的数量 研究人员，（2）扩大中风研究核心服务和用户数量，（3）继续 过渡到通过基于用户的服务在西弗吉尼亚大学的资金模式来维持这些资源。

The Overall Objective of the WVU Stroke CoBRE is to decrease morbidity and mortality related to stroke through improved understanding of pathophysiological mechanism(s) of stroke. We will accomplish this overall goal by conducting high-quality basic and translational research addressing the modifiable risk factors, biomarkers, mechanism(s), preventative strategies, acute and chronic treatments and rehabilitation of stroke. This objective would be met by achieving the following three Specific Aims: Specific Aim 1. Expand the critical mass of funded investigators conducting stroke recovery research. In Phase II we propose to solidify the commitment of investigators to stroke research, in part, by providing cutting-edge stroke research core facilities and services (See Specific Aim 2), generating meaningful preliminary data in support of their grant applications through funding of five Junior Investigator projects, providing grantsmanship workshops/activities to improve their grant applications, and expanding the intensive mentoring program initiated in Phase I of the WVU Stroke CoBRE. Specific Aim 2. Strengthen innovative scientific cores that support and advance basic and translational stroke research. We propose to expand the scope and capacity, as well as the user-base of these vital cores. This will be accomplished by the introduction of new services (e.g., new stroke models; additional behavioral tests), and provide training sessions for research cores. In addition to the Experimental Stroke Core (ESC) and the Rodent Behavior Core (RBC), which are proposed for CoBRE funding, we will develop two additional cores, the Mitochondrial Functional Assessment Core (MFAC) and the Stroke Tissue Bank. Specific Aim 3. Advance the ongoing development of an independent, sustainable, multidisciplinary thematic program of research on stroke. The goal of achieving independences (of CoBRE funding) of the WVU Stroke CoBRE has begun and will continue in Phase II by the transition to a user-fee based funding of research core services, the independent funding of research grants that include funding for these core services and support from the WVU HSC. At the conclusion of Phase II of the WVU Stroke CoBRE, mentored training will have been provided to engage additional JIs in stroke-related research. We will have addressed the need for basic and translational research into the causes, acute and subacute treatments and recovery from stroke by (1) increasing the number of independently funded WVU stroke researchers, (2) expanding stroke research core services and user numbers, and (3) continuing the transition to sustain these resources through a user-based funding model for services at WVU.