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Social Modulation of Microglia

小胶质细胞的社会调节

基本信息

批准号：
9069534
负责人：
Anne Courtney DeVries
金额：
$ 18.94万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-18 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9069534
关键词：
Accounting Address Affect Aging Alzheimer&apos s Disease Animal Disease Models Animal Housing Animals Anxiety Behavior Biological Assay Brain Budgets CD 200 CD80 gene Cardiovascular Diseases Cell Line Central Nervous System Diseases Cerebrovascular Disorders Clinical Cutaneous Data Diabetes Mellitus Disease Disease Progression Exploratory/Developmental Grant Future Goals Health Heart Arrest Hormones House mice Housing Human In Vitro Incidence Individual Individual Differences Inflammatory Interleukin-1 beta Interleukin-10 Laboratories Link Malignant Neoplasms Measures Mediating Mental Depression Mental Health Microglia Morbidity - disease rate Multiple Sclerosis Mus Neuraxis Neurodegenerative Disorders Neurohormones Neurons Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Outcome Measure Oxytocin Pain Paper Phenotype Physiological Physiology Predisposition Process Publishing Research Risk Risk Factors Rodent Model Science Shapes Skin Smoking Social Behavior Social Environment Social Impacts Social Interaction Social isolation Stroke Testing Time Traumatic Brain Injury Variant Work Wound Healing blood lipid cancer type cardiovascular disorder risk cytokine improved in vivo insight mortality neuroinflammation painful neuropathy physical conditioning protein expression psychologic research study response social social attachment therapeutic development

项目摘要

DESCRIPTION (provided by applicant): Social environment contributes to individual differences in the incidence and symptomology of a wide range of human health conditions, including depression, cancer, cardiovascular disease, cerebrovascular disease, wound healing, and neuropathic pain. Our laboratory and others have successfully recapitulated the exacerbating effects of social isolation on outcome in rodent models of these disorders; a common physiological feature of each of these conditions is increased neuroinflammation among socially isolated animals relative to socially housed animals. In turn, neuroinflammation is associated with greater physical and psychological morbidity, although the physiological link between social behavior and neuroinflammation is not known. We propose that oxytocin, a hormone that is released by social interaction, provides a protective function by suppressing the activation of microglia. The specific hypothesis tested in this proposal is that oxytocin reduces the expression of proinflammatory cytokines in the brain by suppressing microglial activation. Converging evidence of oxytocin modulation of microglia will be provided through in vivo and in vitro experiments. The data collected as part of this proposal will increase our understanding of how variation in social environment can impact health. Identification of the physiological factors underlying social influences on health could facilitate the development of therapeutic approaches that improve health measures among people with impoverished social environments.

描述（由申请人提供）：社会环境导致多种人类健康状况的发病率和症状的个体差异，包括抑郁症、癌症、心血管疾病、脑血管疾病、伤口愈合和神经性疼痛。我们的实验室和其他实验室已经成功地重现了社会隔离对这些疾病的啮齿动物模型结果的加剧影响；这些病症的一个共同生理特征是，与社会饲养的动物相比，社会孤立的动物的神经炎症增加。反过来，神经炎症与更高的身体和心理发病率相关，尽管社会行为和神经炎症之间的生理联系尚不清楚。我们认为，催产素是一种通过社交互动释放的激素，通过抑制小胶质细胞的激活来提供保护功能。该提案测试的具体假设是，催产素通过抑制小胶质细胞激活来减少大脑中促炎细胞因子的表达。将通过体内和体外实验提供催产素调节小胶质细胞的综合证据。作为该提案的一部分收集的数据将加深我们对社会环境变化如何影响健康的理解。识别社会对健康影响的生理因素可以促进治疗方法的开发，从而改善社会环境贫困的人们的健康措施。