Stress adaptation in obesity-associated pancreatic cancer

肥胖相关胰腺癌的压力适应

• 批准号: 10581170
• 负责人: Elda Grabocka
• 金额: $ 34.97万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581170
• 关键词: Acids; Allografting; Awareness; Cancer Etiology; Cells; Cessation of life; Chemoprevention; Chemopreventive Agent; Data; Death Rate; Development; Diet; Esters; Genetic; Goals; Growth; Growth Factor; Growth Factor Receptors; Human; In Vitro; Incidence; Inflammatory; Insulin; Intraepithelial Neoplasia; KRAS2 gene; Lesion; Malignant Neoplasms; Malignant neoplasm of pancreas; Mediating; Mediator; Modeling; Molecular; Obese Mice; Obesity; Obesity associated cancer; Organelles; Pancreas; Pancreatic Ductal Adenocarcinoma; Pathway interactions; Play; Prevention strategy; Resistance; Risk; Risk Factors; Role; STAT protein; Signal Transduction; Stress; Stress and Coping; Terpenes; Testing; Time; Tumor Suppression; Tumor Suppressor Proteins; Up-Regulation; cancer diagnosis; cancer risk; coping mechanism; experimental study; fitness; in vivo; insulin mediators; mortality; mouse model; mutant; novel; obesity development; obesity prevention; pancreatic ductal adenocarcinoma cell; pandemic disease; recruit; statistics; stress granule; transcription factor; tumor; tumorigenesis

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项目成果

Stress Granules in Cancer.

• DOI: 10.1007/112_2020_37
• 发表时间: 2023
• 期刊: Reviews of physiology, biochemistry and pharmacology
• 作者: Song MS;Grabocka E
• 通讯作者: Grabocka E

Evaluating Stress Granules in Pancreatic Cancer In Vitro and In Vivo.

体外和体内评估胰腺癌的应激颗粒。

• DOI: 10.1007/978-1-4939-8879-2_17
• 发表时间: 2019
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Sim,Edward;Irollo,Elena;Grabocka,Elda
• 通讯作者: Grabocka,Elda

A Splendid New Beginning at the End of a 40-Year Quest: The First KRASG12D Inhibitor in Pancreatic Cancer.

40 年探索结束后的辉煌新起点：第一个治疗胰腺癌的 KRASG12D 抑制剂。

• DOI: 10.1158/2159-8290.cd-22-1304
• 发表时间: 2023
• 期刊: Cancer discovery
• 影响因子: 28.2
• 作者: Redding,Alexandra;Grabocka,Elda
• 通讯作者: Grabocka,Elda