Assessing the feasibility and acceptability of a Time Restricted Feeding intervention among older adults with Mild Cognitive Impairment

评估对患有轻度认知障碍的老年人进行限制时间喂养干预的可行性和可接受性

• 批准号: 10583672
• 负责人: Patrick Josey Smith
• 金额: $ 52.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583672
• 关键词: Acute; Address; Adherence; Adult; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Animals; Behavioral; Brain; Caloric Restriction; Carbohydrates; Cerebrum; Clinical; Cognition; Cognitive; Collection; Complex; Consumption; Diet Modification; Dietary Practices; Eating; Elderly; Energy Supply; Energy-Generating Resources; Enrollment; Fasting; Feasibility Studies; Future; Geriatrics; Glucose; Glycosylated hemoglobin A; Goals; Hour; Human; Impaired cognition; Impairment; Incidence; Individual; Insulin; Intervention; Ketones; Kynurenic Acid; Link; Measures; Memory; Metabolic; Metabolic Marker; Metabolic dysfunction; Metabolic stress; Metabolic syndrome; Metabolism; Molecular; Obesity; Organ; Participant; Pattern; Physiology; Pilot Projects; Procedures; Protocols documentation; Qualifying; Randomized; Reporting; Research Personnel; Resources; Risk; Risk Factors; Risk Reduction; Sampling; Somatomedins; Source; Time; Time-restricted feeding; Tryptophan; United States; Variant; Work; acceptability and feasibility; acylcarnitine; adult obesity; arm; beta-Hydroxybutyrate; cognitive enhancement; cognitive function; cognitive performance; cognitive testing; comorbidity; dietary; executive function; fatty acid oxidation; flexibility; glucose metabolism; high risk; improved; ketogenic diet; lifestyle intervention; mild cognitive impairment; novel; portability; post intervention; preservation; satisfaction; standard measure

Obesity and related metabolic comorbidities have been associated with more than a 4-fold increased risk of incident cognitive impairment, including Alzheimer’s disease and related dementias (ADRD). Dysfunctional metabolic flexibility is increasingly recognized as a critical mechanism linking metabolic risk factors to risk of cognitive impairment, although few studies portable behavioral strategies to enhance metabolic function among individuals at risk for ADRD. The present study will examine the feasibility and acceptability of a 12-week time restricted feeding intervention among individuals with mild cognitive impairment (MCI). Changes in cognitive and metabolic function will also be examined.

肥胖和相关的代谢合并症已与超过4倍的风险增加， 偶发性认知障碍，包括阿尔茨海默病和相关痴呆（ADRD）。功能失调 代谢的灵活性越来越被认为是一个关键的机制，将代谢危险因素与风险联系起来， 认知障碍，虽然很少有研究便携式行为策略，以提高代谢功能， 有ADRD风险的人。本研究将探讨12周时间的可行性和可接受性 对轻度认知障碍（MCI）患者进行限制性喂养干预。认知和 还将检查代谢功能。