The RSELVES Study: Remote Sensing of (older adult partners') Engagement in Life and Variability in Everyday Support

RSELVES 研究：（老年伴侣）生活参与度和日常支持变化的遥感

• 批准号: 10584401
• 负责人: Lyndsey Medora Miller
• 金额: $ 79.15万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-15 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584401
• 关键词: Acceleration; Activities of Daily Living; Address; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Attention; Cellular Phone; Clinical; Clinical assessments; Cognition; Cognitive; Compensation; Computers; Couples; Data; Dementia; Dependence; Development; Diagnosis; Distress; Elderly; Evaluation; Family member; Frequencies; Goals; Health; Heterogeneity; Home; Hygiene; Impaired cognition; Impairment; Individual; Life; Long-Term Care; Longitudinal Studies; Maintenance; Measures; Mental Health; Modeling; Moods; Natural History; Neurodegenerative Disorders; Oregon; Pattern; Personal Satisfaction; Persons; Phase; Physical activity; Process; Proxy; Public Health; Quality of life; Reporting; Research; Risk; South Texas; Spouses; Surveys; Symptoms; Technology; Time; aging and technology; cohort; cooking; daily functioning; dementia risk; diagnostic criteria; digital; experience; follow-up; functional decline; functional disability; functional loss; high risk; innovation; member; novel; novel strategies; pre-clinical; preservation; prospective; recruit; remote assessment; remote sensing; sensor; social; technology platform; theories; walking speed

PROJECT SUMMARY Alzheimer’s disease is a leading cause of functional disability among older adults worldwide. Despite the inevitability of functional impairment in Alzheimer’s disease, large heterogeneity in the rate and order that specific functions are lost suggests that there are undiscovered ways to slow the progression of functional decline. The majority of older adults are married or co-habiting with an intimate partner, and have daily routines that are interdependent (i.e. synchronous activities or complementary division of functions such as shopping and cooking). Despite strong evidence that interdependence in functioning exists in other older adult couples, there is very little dyadic research on functional decline in the context of preclinical or clinical Alzheimer’s disease. Longitudinal studies have established that the continuum of dementia-related functional decline begins years prior to diagnosis and at wide range of impairment in cognition for most functions. Other previous studies have demonstrated that frequency of engagement in daily activities begins to decline prior to loss of functional abilities. The overall goal of the “RSELVES Study: Remote Sensing of (older adult couples’) Engagement in Life and Variability in Everyday Support” is to examine the intra-dyadic patterns and change in daily life engagement and functional interdependence along cognitive and well-being trajectories in older adult couples at high-risk of developing Alzheimer’s disease. We will use an innovative digital data technology platform developed by the Oregon Center for Aging and Technology, and a dyadic approach informed by the Developmental-Contextual Model of Couple Synchrony to discover changes in life engagement and function in 100 older adult couples. The aims of this study are to characterize baseline interdependence in patterns of life engagement and function among couples with a partner who is at high risk for dementia (Aim 1); evaluate longitudinal dyadic change in life engagement (e.g. dyadic disengagement or partner compensation) and support (Aim 2); and determine the extent to which dyadic life engagement and support appraisals mitigate the influence of cognitive impairment on functional impairment and well-being in older adult couples (Aim 3). Reframing AD-related functional decline in couples as an interdependent process and measuring the degree of synchrony in activities digitally will uncover the early dynamics of changes in life engagement among older adult couples and highlight novel opportunities to target couples’ daily routines in order to delay the “cascade of losses” leading to functional dependence in persons living with AD and degradations to well-being.

项目摘要 阿尔茨海默氏病是全球老年人功能残疾的主要原因。尽管有 在阿尔茨海默氏病中功能障碍的必然性，速度和顺序的较大异质性 失去功能表明，有一些未发现的方法可以减缓功能下降的进展。 大多数老年人已婚或与亲密伴侣共同求婚，并有日常活动 相互依存（即同步活动或互补的功能，例如购物和 烹饪）。尽管有强有力的证据表明在其他老年夫妇中存在相互依存的功能，但 在临床前或临床阿尔茨海默氏病的背景下，关于功能下降的二元研究很少。 纵向研究确定，与痴呆相关的功能下降的连续性开始了数年 在诊断之前和大多数功能的认知障碍范围广泛。以前的其他研究有 证明参与日常活动的频率在失去功能能力之前开始下降。 “自我研究：（老年夫妇”）在生活中的遥感和 日常支持的可变性”是检查野蛮的模式和日常生活参与度的变化和 高风险的老年夫妇的认知和幸福轨迹的功能相互依存关系 发展阿尔茨海默氏病。我们将使用由创新的数字数据技术平台 俄勒冈州老化和技术中心，以及由发展文化的二元方法 夫妇同步的模型，以发现100对老年夫妇的生活参与度和功能变化。这 这项研究的目的是表征基线在生活和功能模式中的相互依存关系 在患有痴呆症风险高风险的伴侣的夫妇中（AIM 1）；评估纵向二元变化 生活参与（例如二元脱离接触或伴侣补偿）和支持（目标2）；并确定 二元生活参与和支持评估的程度减轻了认知障碍的影响 老年人夫妇的功能障碍和福祉（AIM 3）。重塑与广告相关的功能下降 夫妻作为一个相互依存的过程，并在数字上测量活动中的同步程度 老年人夫妻生活变化的早期动态，并突出了新的机会 针对夫妻的日常工作，以延迟“损失的级联”，导致功能依赖性 与广告相处的人并降解对幸福感。