Cincinnati Children's Clinical Center for Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes
辛辛那提儿童临床中心针对青年发病 2 型糖尿病的病理生理学
基本信息
- 批准号:10583296
- 负责人:
- 金额:$ 7.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-10 至 2029-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAgeAnxietyBehaviorBehavioralBeta CellCOVID-19 pandemicCell physiologyCellsCessation of lifeCharacteristicsChildChildhoodChronicClinicalClosure by clampCollaborationsComplexCoupledDataDevelopmentDiabetes MellitusDiagnosisDietDyslipidemiasEpidemiologyEthnic OriginExposure toFailureFrequenciesFunctional disorderFundingFunding OpportunitiesFutureGeneticGenetic RiskGeographyGoalsHealthHormonalHypertensionIncidenceInterventionInvestigationKnowledgeLiteratureLongitudinal StudiesMeasuresMental DepressionMetabolicMonitorMulticenter StudiesNatural HistoryNatureNon-Insulin-Dependent Diabetes MellitusOGTTObesityPancreasPatientsPediatric HospitalsPhenotypePhysical activityPolycystic Ovary SyndromePositioning AttributePreventionProspective StudiesPsychosocial FactorPubertyRaceRecording of previous eventsResearchRiskRisk FactorsRoleRuralSARS-CoV-2 infectionSamplingSecond Degree RelativeSecondary toSeriesSex DifferencesSiteSleepStressStructure of beta Cell of isletTestingTimeUnited StatesUnited States National Institutes of HealthWorkYouthadipokinesclinical centercohortcomorbiditydesignearly onsetethnic differenceexperiencefatty liver diseaseindexinginflammatory markerinsulin secretioninsulin sensitivityintravenous glucose tolerance testobesity in childrenobservational cohort studyparticipant retentionphysical inactivityprenatal exposurepreventprospectivepsychosocialracial differencerecruitresponserisk selectionsexsocioeconomics
项目摘要
PROJECT SUMMARY
For more than two decades through local and multi-center studies our team at Cincinnati Children’s Hospital has
documented the epidemiology of youth-onset type 2 diabetes (T2D) in the US and its associated early-onset co-
morbidities and complications. Furthermore, recent studies show current therapies do not slow or prevent the
progression of youth-onset T2D once it has started, highlighting the aggressive nature of this condition and the
critical need for prevention. Unfortunately, studies to date have failed to yield a sufficient number of youths who
have developed T2D, limiting the ability to define who is at risk and the underlying pathophysiology. As such, we
have developed a prospective, longitudinal observational cohort study along with a series of hypothesis driven
investigations to uncover the pathophysiology leading to youth-onset T2D directly addressing the overarching
objective of this U01 funding opportunity. We propose to recruit a cohort of youth, selected for risk factors
associated with the development of type 2 diabetes. This cohort will undergo detailed studies of pancreatic beta
(β) cell function that include measures of insulin sensitivity and secretion. These studies will be coupled with
assessment of genetics, adiposity, metabolic factors, behavioral and psychosocial risks to elucidate how these
factors influence β-cell function and progression to T2D. Monitoring the proportion of youth in the cohort who
develop T2D and the frequency of associated co-morbidities will fulfill Aim 1, while assessing β-cell function
during puberty and the genetic, metabolic and hormonal factors associated with β-cell function will complete Aim
2. Aim 3, will be achieved by evaluating the role of behavioral and psychosocial factors on β-cell function and
progression to T2D. Cincinnati Children’s Hospital has longstanding, proven clinical and research expertise in
pediatric obesity and youth-onset type 2 diabetes and experience performing complex studies of pancreatic β-
cell function including frequently sampled intravenous glucose tolerance testing, clamp studies, and oral glucose
tolerance testing. Our site also has high patient volumes of race/ethnicity, urban/rural, and socioeconomic
diverse clinical cohorts with documented ability to recruit and retain participants in our prior NIH funded studies,
and we have successfully collaborated in many pediatric multicenter studies. Thus, we are well positioned to
partner in this U01 consortium to advance our understanding of the pathophysiology to youth-onset T2D. This
proposal will refine the phenotype of youth at greatest risk for T2D and identify factors that influence β-cell
function and the progression to T2D. This will position the consortium to develop targeted interventions to prevent
youth-onset T2D as a next step.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMY SANGHAVI SHAH其他文献
AMY SANGHAVI SHAH的其他文献
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{{ truncateString('AMY SANGHAVI SHAH', 18)}}的其他基金
Understanding the Role of HDL Subspecies in Adolescents with Type 2 Diabetes
了解 HDL 亚种在 2 型糖尿病青少年中的作用
- 批准号:
8699942 - 财政年份:2014
- 资助金额:
$ 7.03万 - 项目类别:
Understanding the Role of HDL Subspecies in Adolescents with Type 2 Diabetes
了解 HDL 亚种在 2 型糖尿病青少年中的作用
- 批准号:
9032519 - 财政年份:2014
- 资助金额:
$ 7.03万 - 项目类别:
Understanding the Role of HDL Subspecies in Adolescents with Type 2 Diabetes
了解 HDL 亚种在 2 型糖尿病青少年中的作用
- 批准号:
9235149 - 财政年份:2014
- 资助金额:
$ 7.03万 - 项目类别:
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