The Effectiveness and Cost-Effectiveness of Implementing Evidence-Based Depression Treatment within the TB Care Platform in South Africa: A Hybrid Effectiveness-Implementation Trial

在南非结核病护理平台内实施循证抑郁症治疗的有效性和成本效益：一项混合有效性与实施试验

• 批准号: 10582160
• 负责人: Annika Claire Sweetland
• 金额: $ 7.19万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582160
• 关键词: Address; Caliber; Caring; Data; Data Collection; Effectiveness; Funding; Goals; Grant; Manuscripts; Mental Depression; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Paper; Parents; Patients; Preparation; Prevalence; Primary Care; Research; Research Activity; Research Methodology; Research Personnel; Research Support; Resource-limited setting; Science; Scientist; Site; South Africa; Structure; Training; Writing; career; career development; contextual factors; cost effectiveness; dissemination science; effectiveness/implementation trial; evidence base; experience; hands on research; hazardous drinking; implementation science; skills; social

PROJECT SUMMARY We propose a Diversity Supplement for Dr. Ernesha Webb Mazinyo to provide her the appropriate setting, training, individualized mentoring and research experience necessary to launch her career as an independently- funded implementation scientist. In order to achieve this goal, Dr. Webb Mazinyo will receive mentoring and research support, didactic coursework in dissemination and implementation science (D&I), hands-on research experience including primary data collection and mixed-methods analysis, and assistance with grant writing and manuscript preparation. Dr. Webb Mazinyo will be mentored by Drs. Annika Sweetland (PI), Andrew Medina- Marino (site-PI, Co-I) and Milton Wainberg (Co-I), to advise her as she pursues D&I research focused on integrating TB, depression and hazardous drinking (HD) treatment within primary care. Drs. Sweetland, Medina- Marino, and Wainberg have relevant methodological expertise in D&I science and mixed-methods research; topical expertise on the intersection of TB, depression and HD; and a successful track-record mentoring early investigators. This application builds upon the parent-study by expanding the scientific scope to include HD among TB patients with and without depression. Dr. Webb Mazinyo will participate in all research activities related to the parent study, including the preparation and submission of scientific papers/proposals, along with didactic and career development activities. Dr. Webb Mazinyo’s hands-on research will include two research aims: AIM 1: To leverage parent study data to estimate the prevalence and social correlates of HD among TB patients with and without depression. AIM 2: To investigate contextual factors and potential barriers/facilitators to integrating treatment for depression and HD within the TB care platform. Taken together, the research activities proposed for this Diversity Supplement will develop Dr. Webb Mazinyo’s D&I research skills and will provide the structure and support needed for her to become a highly successful independent researcher able to address integration of treatment for HD for patients with TB in South Africa and other low-resource settings. Our main objective is to support Dr. Webb Mazinyo to apply for and obtain a K01 award to support her goal of becoming a researcher of the highest caliber in the field of D&I.

项目总结 我们建议为Erensha Webb Mazinyo博士提供多样性补充，为她提供适当的环境， 培训、个性化指导和研究经验是她独立开始职业生涯所必需的- 资助实施科学家。为了实现这一目标，韦布·马齐约博士将接受指导和 研究支持，传播和实施科学(D&I)的教学课程，实践研究 经验，包括主要数据收集和混合方法分析，并协助编写赠款和 手稿准备工作。Webb Mazinyo博士将由Annika Sweetland(PI)博士、Andrew Medina博士指导- Marino(Site-PI，Co-I)和Milton Wainberg(Co-I)，在她从事专注于以下方面的D&I研究时为她提供建议 将结核病、抑郁症和危险饮酒(HD)治疗纳入初级保健。斯威特兰博士，麦地那- Marino和Wainberg在D&I科学和混合方法研究方面拥有相关的方法论专业知识； 关于结核病、抑郁症和HD交集的专题专业知识；以及早期成功的跟踪指导 调查人员。这一应用程序建立在家长研究的基础上，将科学范围扩展到包括HD 在患有和不患有抑郁症的结核病患者中。韦伯·马津约博士将参加所有研究活动 与母研究有关，包括编写和提交科学论文/提案，以及 教学和职业发展活动。Webb Mazinyo博士的实践研究将包括两项研究 目标： 目标1：利用父母研究数据来评估结核病中HD的患病率和社会相关性 患有和不患有抑郁症的患者。 目标2：调查整合治疗的环境因素和潜在障碍/促进者 结核病护理平台内的抑郁和HD。 综上所述，为本多样性补充材料提出的研究活动将发展Webb Mazinyo博士的 D&I研究技能，并将提供必要的结构和支持，使她成为一个非常成功的 独立研究人员能够解决南非和南非结核病患者HD治疗的整合问题 其他资源不足的设置。我们的主要目标是支持Webb Mazinyo博士申请并获得K01 奖项支持她成为D&I领域最高水平的研究员的目标。