Metabolic Tissue Function

项目摘要：新陈代谢组织功能核心 新陈代谢组织功能核心的目的是提高糖尿病相关患者的工作效率 通过提供专业知识、设备和服务来优化调查能力进行研究 华盛顿大学糖尿病研究中心(DRC)成员。核心促进HIGH的收购 高质量的啮齿动物和人类胰岛，并协助研究人员开发诱导多能干细胞。 此外，该中心还为胰岛和其他代谢组织的功能分析提供服务 与糖尿病及其并发症的发病机制有关。这些功能研究包括激素 分泌物分析、细胞质量的评估、新陈代谢的量化和其他 糖尿病发病机制的关键变量。核心为34个不同的刚果民主共和国成员提供服务 在过去的供资期间，包括6名P&F获得者在内的实验室，这些服务支持 发表论文51篇。新陈代谢组织功能核心，通过其独特的专业知识，最先进的 因此，设备和服务有相当大的潜力促进新疗法的开发 可能改善患有糖尿病、糖尿病前期、相关内分泌和代谢的美国人的健康 疾病及其毁灭性的并发症。

PROJECT SUMMARY: Metabolic Tissue Function Core The purpose of the Metabolic Tissue Function Core is to improve the efficiency of diabetes-related research through provision of expertise, equipment, and services that optimize the investigational capacity of Washington University Diabetes Research Center (DRC) members. The Core facilitates acquisition of high quality rodent and human islets and assists investigators in developing induced pluripotent stem cells. In addition, the Core provides services for the functional analyses of islets and other metabolic tissues relevant to the pathogenesis of diabetes and its complications. These functional studies include hormone secretion assays, assessment of -cell mass, quantification of metabolism, and characterization of other variables critical to the pathogenesis of diabetes. The Core provided services to 34 different DRC member laboratories during the past funding period, including 6 P&F recipients, and these services supported the publication of 51 papers. The Metabolic Tissue Function Core, through its unique expertise, state-of-the-art equipment, and services, thus has considerable potential to contribute to the development of new therapies likely to improve the health of Americans with diabetes, prediabetes, related endocrine and metabolic diseases, and their devastating complications.