Novel cellular trafficking mechanisms for the drug influx transporter, human Organic Anion Transporting Polypeptide 1A2 (OATP1A2)

药物流入转运蛋白、人有机阴离子转运多肽 1A2 (OATP1A2) 的新型细胞转运机制

• 批准号: nhmrc : 1025101
• 负责人: Dr Fanfan Zhou
• 金额: $ 22.51万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-cellular-trafficking-1a2-oatp1a2/110406
• 关键词: Novel; cellular; trafficking; mechanisms; drug

Human organic anion transporting polypeptides (OATPs) are membrane proteins that regulate the cellular uptake of endogenous and exogenous substances including anti-cancer drugs. OATPs strongly determine whether such drugs enter the tissues where they are required to exert their effects. This project will study novel mechanisms that we have recently identified that determine the orientation of transporters in the cells. These processes can be impaired by a common pharmacogenetic variant in individuals.

人有机阴离子转运多肽（OATPs）是一种调节细胞对内源性和外源性物质（包括抗癌药物）摄取的膜蛋白。OATP强烈决定这些药物是否进入需要它们发挥作用的组织。该项目将研究我们最近发现的决定细胞中转运蛋白方向的新机制。这些过程可能受到个体中常见的药物遗传学变异的损害。