Mentorship in patient-oriented research on behavioral and social determinants of cardiometabolic health

指导以患者为中心的心脏代谢健康行为和社会决定因素的研究

• 批准号: 10589326
• 负责人: Anne N Thorndike
• 金额: $ 12.65万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10589326
• 关键词: Address; Adherence; Adult; Appointment; Architecture; Award; Behavior; Behavior Therapy; Behavioral; Beverages; Blood Pressure; Body mass index; Cardiometabolic Disease; Chronic; Chronic Disease; Collaborations; Communities; Community Developments; Community Health Aides; Consumption; Data; Dedications; Development; Diet; Diet Modification; Dietary Intervention; Dietary intake; Disease; Education; Effectiveness; Effectiveness of Interventions; Faculty; Food; Food Labeling; Frontline worker; Funding; Future; General Hospitals; General Practices; Goals; Health; Health Food; Health behavior; Healthcare; High Prevalence; Home; Hypertension; Individual; Infrastructure; Internist; Intervention; Interview; Knowledge; Label; Life Style; Light; Longitudinal cohort; Low Income Population; Low income; Massachusetts; Medical; Medicine; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Monitor; Neighborhood Health Center; Nutritional; Outcome; Paper; Participant; Patients; Personal Satisfaction; Pharmaceutical Preparations; Pilot Projects; Policies; Populations at Risk; Postdoctoral Fellow; Prevention; Primary Care; Process; Public Health; Publications; Randomized; Research; Research Personnel; Research Support; Resources; Security; Sleep; Socioeconomic Factors; Students; Supermarket; Surveys; Testing; Time; Training; Unhealthy Diet; United States National Institutes of Health; Visit; Workplace; Writing; acceptability and feasibility; adverse outcome; blood pressure control; cardiometabolic risk; cardiometabolism; cardiovascular health; cardiovascular risk factor; career; career development; cohort; community setting; design; dietary; disease disparity; dissemination research; experience; food insecurity; food resource; food security; health care availability; health care service utilization; high risk; hypertension control; implementation intervention; implementation research; improved; improved outcome; interest; marginalized population; medical schools; medication compliance; mid-career faculty; novel; novel strategies; nutrition; nutrition education; participant enrollment; patient engagement; patient oriented; patient oriented research; pilot test; prevent; primary care patient; primary outcome; programs; psychologic; secondary outcome; social; social determinants; social factors; social health determinants; socioeconomic disparity; socioeconomics

Anne Thorndike, MD, MPH is a practicing general internist at Massachusetts General Hospital (MGH) and an Associate Professor of Medicine at Harvard Medical School. The purpose of this K24 mid-career investigator award is to support Dr. Thorndike’s mentorship and patient-oriented research focused on health behaviors and social determinants of health in the prevention and treatment of cardiometabolic disease. Over the past 10 years, her research in workplace and community settings has tested novel behavioral strategies to promote healthy dietary intake and other healthy behaviors to prevent chronic disease, particularly in low-income populations with high prevalence of food insecurity and other unmet health-related social needs. Many of these strategies, such as traffic-light food labeling and choice architecture (product placement), have been broadly disseminated through academic, governmental, and lay publications. Dr. Thorndike is a dedicated mentor, and she has supported over 25 junior faculty, medical residents, postdoctoral fellows, and students. Her mentees have written 19 first author papers (5 in process) and have received 5 NIH K23 awards (1 in review). In this K24 application, Dr. Thorndike proposes a mentoring, career development, and research plan with inter-related goals that will help advance the research of Dr. Thorndike and her mentees to address some of the most intractable behavioral and social factors that contribute to cardiometabolic disease disparities. The overall objectives of the K24 award are: 1) To enable Dr. Thorndike to dedicate 25% protected time for mentoring early-career investigators conducting patient-oriented research focused on health behaviors and social determinants of cardiometabolic health, 2) To have a platform for mid-career professional development and training, in collaboration with expert collaborators and co-mentors, and 3) To integrate her existing NIH-funded research with new research supported by this award that will support a future R01 submission. The proposed research uses mixed methods to develop a community health worker (CHW) nutrition intervention for community health center patients experiencing uncontrolled hypertension and food insecurity. Research Aim 1 will leverage the existing longitudinal “LiveWell” cohort of over 1,000 community health center patients (R01 DK124145, Thorndike) to conduct formative research that will inform the development of the CHW nutrition intervention. Using the infrastructure of an existing MGH CHW hypertension program, Research Aim 2 will be a randomized 6-month pilot study to determine feasibility and acceptability of delivering a nutrition intervention with CHWs and to determine preliminary effectiveness of the intervention on patients’ dietary intake, blood pressure, body mass index, and depression. Dr. Thorndike’s ongoing NIH-funded research and proposed new research provide opportunities for mentorship in patient-oriented research focused on the development and implementation of interventions that will improve outcomes and reduce socioeconomic disparities in cardiometabolic health.

Anne Thorndike，医学博士，公共卫生硕士，马萨诸塞州综合医院(MGH)执业全科医生， 哈佛医学院医学副教授。这位K24职业生涯中期调查员的目的是 该奖项是为了支持桑代克博士的指导和以患者为导向的研究，重点是健康行为和 预防和治疗心脏代谢性疾病中健康的社会决定因素。在过去10年中 多年来，她在工作场所和社区环境中的研究测试了新的行为策略以促进 健康的饮食摄入和其他健康行为，以预防慢性病，特别是在低收入人群 粮食不安全和其他未得到满足的与健康有关的社会需求普遍存在的人口。其中许多 战略，如红绿灯食品标签和选择架构(产品植入)已得到广泛应用 通过学术、政府和非专业出版物传播。桑代克博士是一位敬业的导师， 她为超过25名初级教员、住院医师、博士后研究员和学生提供了支持。她的师徒 已经撰写了19篇第一作者论文(5篇正在进行中)，并获得了5项NIH K23奖(1项在审查中)。在这 K24应用，Thorndike博士提出了一个指导、职业发展和研究计划 目标将有助于推进桑代克博士和她的学员的研究，以解决一些最 导致心脏代谢性疾病差异的棘手的行为和社会因素。整体而言 K24奖项的目标是：1)使桑代克博士能够将25%的受保护时间用于指导 职业生涯早期的研究人员进行以病人为中心的研究，重点是健康行为和社会 心脏代谢健康的决定因素，2)有一个职业中期职业发展的平台和 与专家合作者和共同导师合作进行培训，以及3)整合她现有的NIH资助 由该奖项支持的新研究将支持未来的R01提交。建议数 研究采用混合方法开发社区卫生工作者(CHW)营养干预 社区卫生中心患有失控高血压和食物不安全的患者。研究目标1 将利用现有的1,000多名社区卫生中心患者的纵向“LiveWell”队列(R01 DK124145，Thorndike)进行形成性研究，为CHW营养的发展提供信息 干预。利用现有MGH CHW高血压计划的基础设施，研究目标2将是 确定提供营养干预的可行性和可接受性的随机6个月试点研究 并初步确定干预对患者膳食摄入量、血液摄入量的影响 压力、体重指数和抑郁症。桑代克博士正在进行的由美国国立卫生研究院资助的研究并提出了新的 研究为以患者为中心的研究提供指导的机会，重点是发展和 实施干预措施，以改善成果并缩小#年的社会经济差距 心脏代谢健康。