BLRD Research Career Scientist Award Application

里斯布勒博士开展了一个跨物种的翻译研究项目，以研究 创伤障碍包括创伤后应激障碍(PTSD)和创伤性脑损伤 (待定)。她的整个计划旨在支持新疗法的开发和 为患有创伤后应激障碍和脑外伤的退伍军人提供诊断/预后工具。里斯布罗博士把她的注意力集中在 确定风险机制和确定潜在新药的临床前研究计划 利用遗传学、分子和药理学手段治疗小鼠创伤后应激障碍。她是众所周知的 以表彰她在创伤后应激障碍动物模型和压力系统神经生物学方面的专业知识。她目前的情况 临床前工作包括识别恐惧学习和灭绝的遗传风险标记， 确定睡眠和免疫系统对创伤后应激障碍和酒精共病风险的影响 饮酒和确定针对多巴胺和内源性大麻系统的新治疗方法 加强基于恐惧消退的治疗。她的临床研究项目包括识别 创伤后应激障碍和脑外伤的心理社会、生理和血液生物标记物 了解阻碍康复和导致功能障碍的机制以改善 干预性发展。该计划包括管理圣地亚哥退伍军人管理局睡眠研究 弗吉尼亚州压力和心理健康卓越中心心理生理学实验室 精神卫生(CESAMH)，CESAMH和HER的纵向创伤后应激障碍/创伤后应激障碍生物库 继续作为海洋适应性研究的首席调查员工作，前景 OIF/OEF海军陆战队的纵向研究，现正处于10年的跟踪收集期。最后， 她还进行临床研究，以确定创伤后应激障碍的新药物治疗方法。她 研究项目由NIMH、NIAAA、国防部以及VA BLR&D资助 以及退伍军人事务部压力和心理健康基金卓越中心。

Dr. Risbrough runs a cross-species translational research program to study mechanisms of trauma disorders including posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). Her overall program aims to support development of novel treatments and diagnostic/prognostic tools for Veterans with PTSD and TBI. Dr. Risbrough focuses her preclinical research program on identifying mechanisms of risk and identifying potential novel treatments for PTSD using genetic, molecular and pharmacological tools in mice. She is known for her expertise in animal models of PTSD and the neurobiology of stress systems. Her current preclinical work includes identifying genetic risk markers for fear learning and extinction, identifying sleep and immune-system contributors to risk for PTSD and comorbid alcohol drinking and identifying novel treatments targeting dopamine and endocannabinoid systems to enhance fear-extinction based therapies. Her clinical research program includes identifying psychosocial, physiological and blood-based biomarkers of PTSD and TBI aimed at understanding mechanisms that impede recovery and induce functional impairment to improve intervention development. This program includes managing the San Diego VA Sleep Research Laboratory, the Psychophysiology Laboratory for the VA Center of Excellence for Stress and Mental Health (CESAMH), longitudinal PTSD/TBI Biorepository for CESAMH as well as her continued work as a Principal Investigator for the Marine Resiliency Study, a prospective longitudinal study of OIF/OEF Marines now in its 10 year follow up collection period. Finally, she also conducts clinical studies to identify novel pharmacological treatments for PTSD. Her research program is funded by NIMH, NIAAA, Department of Defense in addition to VA BLR&D and VA Center of Excellence for Stress and Mental Health funds.