Making data accessible: a rebuild and expansion of BrainRNAseq.org

使数据可访问：BrainRNAseq.org 的重建和扩展

• 批准号: 10588169
• 负责人: Shane Liddelow
• 金额: $ 8.75万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588169
• 关键词: Advertising; Advocate; Age; Algorithms; Big Data; Code; Communities; Consult; Country; Data; Data Set; Databases; Dedications; Development; Engineering; Ensure; Esthetics; Faculty; Feedback; Future; Gene Expression; Home; Individual; Intention; Internet; Light; Link; Medical Students; Mus; Neurosciences; Output; Paralysed; Proteomics; Recommendation; Resources; Scientist; Series; Side; Site; Software Engineering; Source; Standardization; Time; Training; Vision; Visual; Visualization; Walking; Work; cell type; data acquisition; data sharing; design; experience; human data; interest; meetings; metabolomics; posters; repaired; repository; searchable database; tool; transcriptome sequencing; transcriptomics; user-friendly; web app; web site

Project Summary Big datasets are now a routine output for many studies. A corollary of this reality is the ever-growing need to disseminate this information to other scientists, a feat that presents its own challenges. Over 7 years ago, we found ourselves grappling with these very questions because we had generated a series of mouse and human datasets that we felt would greatly benefit the glial (and greater neuroscience) community. After many iterations, we developed a website called BrainRNAseq.org, a central source where other scientists could easily and quickly access our data—whether they were browsing at home, or while walking down the poster aisle at a meeting. Over time, this website has become a staple within our scientific community and currently garners over 250 users per day, with over 56,000 different users in the past 3 years alone. However, the site is in need of back-end repairs to ensure its utility for the foreseeable future. In the first aim of this proposal, we will rebuild the site while maintaining its user interface and adding user-requested upgrades. Our second aim is to build a free application that will enable other creators to build similar sites with ease. Creators will need no coding experience—only a .csv file with their data, and our application (Dataspectra 2.0) will provide a suite of simple aesthetic options to construct a user-friendly website where others can explore and download their data. Finally, to consolidate the growing number of datasets currently scattered across the web, we will create “Barreseq”—a central repositiory for glial datasets where trainees and faculty and quickly apply filters (species, data type, age, etc) to identify relevant datasets for their specific interests. We envision a paradigm in which data sharing moves towards standardization. We want to build the tools necessary to lower the activation energy for individuals to share their data, and to do so in a mechanism that is visually familiar and digestible to other users. We believe that this will strengthen our scientific community, both in terms of generating stronger hypotheses, and in the spirit of more easily sharing the valuable resources that everyone is producing.

项目摘要 大数据集现在是许多研究的常规输出。这一现实的必然结果是， 将这一信息传播给其他科学家，这一壮举本身就提出了挑战。七年前，我们 我们发现自己正在努力解决这些问题，因为我们已经产生了一系列的小鼠和人类 我们认为这些数据集将极大地有益于神经胶质（和更大的神经科学）社区。经过多次迭代， 我们开发了一个名为BrainRNAseq.org的网站，一个其他科学家可以轻松 快速访问我们的数据-无论他们是在家里浏览，还是在海报通道上走着， 会议随着时间的推移，这个网站已经成为我们科学界的一个主要内容，目前已经获得了 每天250个用户，仅在过去3年就有超过56，000个不同的用户。然而，该网站需要 后端维修，以确保其在可预见的未来的效用。在本提案的第一个目标中，我们将重建 站点，同时维护其用户界面并添加用户请求的升级。我们的第二个目标是建立一个自由的 该应用程序将使其他创作者能够轻松构建类似的网站。创作者将不需要编码 经验-只有一个.csv文件与他们的数据，我们的应用程序（Dataspectra 2.0）将提供一套简单的 美学选项来构建一个用户友好的网站，其他人可以探索和下载他们的数据。最后， 为了整合目前分散在网络上的越来越多的数据集，我们将创建“Barreseq”-一个 神经胶质数据集的中央存储库，学员和教员可以快速应用过滤器（物种，数据类型，年龄， 等），以确定其特定利益的相关数据集。我们设想了一个数据共享模式， 走向标准化。我们希望建立必要的工具来降低个人的激活能， 共享他们的数据，并以其他用户视觉上熟悉和易于理解的机制来这样做。我们认为 这将加强我们的科学界，无论是在产生更强的假设方面， 更容易分享每个人都在生产的宝贵资源的精神。