Animal Physiology Core

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The Animal Physiology Core (APC) provides a comprehensive array of services overseen by Dr. Habegger with three Associate Directors and incorporates a high level of expertise in the areas of integrative physiology, glucose homeostasis, mitochondrial metabolism and redox biology, and animal models as a core resource for the study of diabetes and cardiometabolic disease. The goal of the APC is to provide easy access to highly-specialized equipment, technology, and expertise in the area of body composition, energetics, glucose homeostasis, cardiovascular assessment, imaging, and transgenic animal models and technology to augment diabetes research capacity, quality, and cost effectiveness. The Specific Aims of the Core are: 1. To provide expertise in the use of animal models for diabetes research; 2. To provide state-of-the-art instrumentation and methodology for the determination of: Body composition, Energy expenditure and balance, Substrate metabolism, Glucose homeostasis, Insulin sensitivity and secretion, Mitochondria & Cellular Metabolism, Oxidative & Hormonal Stress, and the generation of Genetically modified animal models. 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the APC was founded with the DRC in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By disseminating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active supporting 210 funded projects from 154 investigators conducting diabetes research. Moreover, the data provided by the core became the basis of numerous federal grants and led to many high-quality publications.