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Animal Physiology Core

动物生理学核心

基本信息

批准号：
10588883
负责人：
Kirk Michael Habegger
金额：
$ 33.44万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588883
关键词：
Access to Information Alabama Animal Model Animals Architecture Area B-Lymphocytes Bioenergetics Biology Body Composition Body Temperature Body Weight Cardiometabolic Disease Cardiovascular system Cell physiology Chemicals Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Data Diabetes Mellitus Diet Dual-Energy X-Ray Absorptiometry Eating Energy Metabolism Enzyme Kinetics Equipment Evaluation Functional disorder Funding Generations Genes Genetically Modified Animals Genotype Glucose Glucose Clamp Glutathione Disulfide Goals Grant Hormonal Human Hydrogen Peroxide Hyperinsulinism Image In Vitro Indirect Calorimetry Insulin Isoprostanes Knock-in Knock-out Lipid Peroxidation Magnetic Resonance Measures Metabolism Methodology Methods Miniaturization Mitochondria Modeling Nature Output Oxidation-Reduction Oxidative Stress Patients Permeability Pharmaceutical Preparations Phenotype Physiology Preparation Process Production Productivity Publications Reagent Research Research Personnel Resolution Resources Rodent Rodent Model Services Spirometry Stress Superoxide Dismutase Technology Tissues Training Transgenic Animals Transgenic Model Transgenic Organisms Translational Research Universities base blood glucose regulation cardiovascular risk factor cost effectiveness cost efficient design energy balance glucose metabolism glucose tolerance human disease improved in vivo instrumentation insulin secretion insulin sensitivity insulin tolerance islet metabolic rate microCT mitochondrial metabolism monitoring device morphometry multidisciplinary tool translational pipeline

项目摘要

The Animal Physiology Core (APC) provides a comprehensive array of services overseen by Dr. Habegger with three Associate Directors and incorporates a high level of expertise in the areas of integrative physiology, glucose homeostasis, mitochondrial metabolism and redox biology, and animal models as a core resource for the study of diabetes and cardiometabolic disease. The goal of the APC is to provide easy access to highly-specialized equipment, technology, and expertise in the area of body composition, energetics, glucose homeostasis, cardiovascular assessment, imaging, and transgenic animal models and technology to augment diabetes research capacity, quality, and cost effectiveness. The Specific Aims of the Core are: 1. To provide expertise in the use of animal models for diabetes research; 2. To provide state-of-the-art instrumentation and methodology for the determination of: Body composition, Energy expenditure and balance, Substrate metabolism, Glucose homeostasis, Insulin sensitivity and secretion, Mitochondria & Cellular Metabolism, Oxidative & Hormonal Stress, and the generation of Genetically modified animal models. 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the APC was founded with the DRC in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By disseminating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active supporting 210 funded projects from 154 investigators conducting diabetes research. Moreover, the data provided by the core became the basis of numerous federal grants and led to many high-quality publications.

动物生理学核心（APC）提供一系列全面的服务，由Habegger博士监督