A new PET neuroimaging probe for sigma 1 receptor

一种新的 Sigma 1 受体 PET 神经影像探针

• 批准号: 10272877
• 负责人: Changning Wang
• 金额: $ 25.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10272877
• 关键词: Affinity; Animals; Astrocytes; Automation; Binding; Biochemical Process; Brain; Brain Diseases; Brain imaging; Cell membrane; Clinical Research; Clinical Trials; Coupled; Data; Development; Diagnosis; Disease; Drug Addiction; Drug Kinetics; Endocrine; Endoplasmic Reticulum; Evaluation; Functional disorder; Goals; Grant; Human; Ideal 1; Image; Imaging Device; Imaging Techniques; Immune; In Vitro; Investigative Techniques; Ion Channel; Kinetics; Lead; Ligands; Maximum Tolerated Dose; Measurement; Measures; Mechanics; Medical Research; Membrane; Mental disorders; Metabolism; Methods; Microglia; Molecular Chaperones; Nerve Degeneration; Neuraxis; Neurons; Neurotransmitter Receptor; Nuclear Envelope; Oligodendroglia; Opioid; Pain; Pain management; Pathologic; Pathologic Processes; Pathway interactions; Patients; Peripheral; Physiological Processes; Plasma; Positron-Emission Tomography; Process; Property; Proteins; Reporting; Research; Rodent; Role; Safety; Sensory; Specificity; Structure; Techniques; Testing; Therapeutic; Tissues; Tracer; Translating; Translational Research; Validation; brain research; cell type; design; dosimetry; drug discovery; experience; human disease; human imaging; human study; imaging agent; imaging probe; imaging study; improved; in vivo; in vivo imaging; kinetic model; man; mitochondrial membrane; molecular imaging; neuroimaging; non-invasive imaging; nonhuman primate; novel; pre-clinical; radiotracer; receptor; receptor binding; receptor expression; receptor function; sigma-1 receptor; small molecule therapeutics; success; technique development; therapeutic target; tool; uptake

Project Summary Sigma 1 receptor (σ1R) has been implicated in multiple functions and associated with various human diseases, including brain diseases/disorders. σ1R has been reported to interact with numerous neurotransmitter receptors and ion channels, and involved in diverse basic biochemical processes and pathological conditions related to neurodegeneration, pain sensitization, psychiatric disorders, and drug addiction. Therefore, it is important to have a tool for non-invasive measurement of σ1R expression and function in vivo, and PET imaging would be an ideal tool. Unfortunately, to date, there are no suitable non-invasive neuroimaging tools for investigating these processes in animals or in man. The development of techniques for visualizing σ1R in vivo represents a key step in understanding both the normal function and pathophysiology of σ1R in brain. Moreover, these techniques will accelerate the discovery of small molecule therapeutics that selectively interacts with σ1R. The project is designed to validate a novel PET imaging probe, [18F]CNY-05, for σ1R imaging in rodents and non-human primates.

项目摘要 SIGMA-1受体(σ-1R)参与多种功能，并与多种人类疾病相关。 包括脑部疾病/紊乱。据报道，σ1R与多种神经递质受体相互作用 和离子通道，并参与各种基本的生化过程和相关的病理条件 神经变性、疼痛敏感化、精神障碍和药物成瘾。因此，重要的是要 拥有一种非侵入性测量体内σ1R表达和功能的工具，PET成像将成为 一个理想的工具。 不幸的是，到目前为止，还没有合适的非侵入性神经成像工具来研究这些过程 无论是在动物身上还是在人类身上。σ1R活体可视化技术的发展是 了解σ1R在脑内的正常功能和病理生理。此外，这些技术将 加快发现选择性与σ1R相互作用的小分子疗法。该项目是 设计用于验证一种新型正电子发射计算机断层成像探针[18F]CNY-05，用于啮齿动物和非人类的σ1R成像 灵长类动物。