A new PET neuroimaging probe for sigma 1 receptor
一种新的 Sigma 1 受体 PET 神经影像探针
基本信息
- 批准号:10272877
- 负责人:
- 金额:$ 25.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffinityAnimalsAstrocytesAutomationBindingBiochemical ProcessBrainBrain DiseasesBrain imagingCell membraneClinical ResearchClinical TrialsCoupledDataDevelopmentDiagnosisDiseaseDrug AddictionDrug KineticsEndocrineEndoplasmic ReticulumEvaluationFunctional disorderGoalsGrantHumanIdeal 1ImageImaging DeviceImaging TechniquesImmuneIn VitroInvestigative TechniquesIon ChannelKineticsLeadLigandsMaximum Tolerated DoseMeasurementMeasuresMechanicsMedical ResearchMembraneMental disordersMetabolismMethodsMicrogliaMolecular ChaperonesNerve DegenerationNeuraxisNeuronsNeurotransmitter ReceptorNuclear EnvelopeOligodendrogliaOpioidPainPain managementPathologicPathologic ProcessesPathway interactionsPatientsPeripheralPhysiological ProcessesPlasmaPositron-Emission TomographyProcessPropertyProteinsReportingResearchRodentRoleSafetySensorySpecificityStructureTechniquesTestingTherapeuticTissuesTracerTranslatingTranslational ResearchValidationbrain researchcell typedesigndosimetrydrug discoveryexperiencehuman diseasehuman imaginghuman studyimaging agentimaging probeimaging studyimprovedin vivoin vivo imagingkinetic modelmanmitochondrial membranemolecular imagingneuroimagingnon-invasive imagingnonhuman primatenovelpre-clinicalradiotracerreceptorreceptor bindingreceptor expressionreceptor functionsigma-1 receptorsmall molecule therapeuticssuccesstechnique developmenttherapeutic targettooluptake
项目摘要
Project Summary
Sigma 1 receptor (σ1R) has been implicated in multiple functions and associated with various human diseases,
including brain diseases/disorders. σ1R has been reported to interact with numerous neurotransmitter receptors
and ion channels, and involved in diverse basic biochemical processes and pathological conditions related to
neurodegeneration, pain sensitization, psychiatric disorders, and drug addiction. Therefore, it is important to
have a tool for non-invasive measurement of σ1R expression and function in vivo, and PET imaging would be
an ideal tool.
Unfortunately, to date, there are no suitable non-invasive neuroimaging tools for investigating these processes
in animals or in man. The development of techniques for visualizing σ1R in vivo represents a key step in
understanding both the normal function and pathophysiology of σ1R in brain. Moreover, these techniques will
accelerate the discovery of small molecule therapeutics that selectively interacts with σ1R. The project is
designed to validate a novel PET imaging probe, [18F]CNY-05, for σ1R imaging in rodents and non-human
primates.
项目摘要
SIGMA-1受体(σ-1R)参与多种功能,并与多种人类疾病相关。
包括脑部疾病/紊乱。据报道,σ1R与多种神经递质受体相互作用
和离子通道,并参与各种基本的生化过程和相关的病理条件
神经变性、疼痛敏感化、精神障碍和药物成瘾。因此,重要的是要
拥有一种非侵入性测量体内σ1R表达和功能的工具,PET成像将成为
一个理想的工具。
不幸的是,到目前为止,还没有合适的非侵入性神经成像工具来研究这些过程
无论是在动物身上还是在人类身上。σ1R活体可视化技术的发展是
了解σ1R在脑内的正常功能和病理生理。此外,这些技术将
加快发现选择性与σ1R相互作用的小分子疗法。该项目是
设计用于验证一种新型正电子发射计算机断层成像探针[18F]CNY-05,用于啮齿动物和非人类的σ1R成像
灵长类动物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Changning Wang其他文献
Changning Wang的其他文献
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{{ truncateString('Changning Wang', 18)}}的其他基金
BET-BD1 Selective Neuroimaging probes for Alzheimer's disease research
用于阿尔茨海默病研究的 BET-BD1 选择性神经影像探针
- 批准号:
10628245 - 财政年份:2023
- 资助金额:
$ 25.06万 - 项目类别:
Investigation of sirtuin 1 expression in mice model of Alzheimer's disease over age
随年龄增长的阿尔茨海默病小鼠模型中去乙酰化酶 1 表达的研究
- 批准号:
10407173 - 财政年份:2022
- 资助金额:
$ 25.06万 - 项目类别:
Selective PET imaging probes targeting BD1 of N-terminal bromodomains
靶向 N 端溴结构域 BD1 的选择性 PET 成像探针
- 批准号:
10054837 - 财政年份:2020
- 资助金额:
$ 25.06万 - 项目类别:
Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's disease
RIPK1/坏死性凋亡作为阿尔茨海默病关键生物标志物的分子成像
- 批准号:
10378615 - 财政年份:2020
- 资助金额:
$ 25.06万 - 项目类别:
Molecular imaging of PS1/gamma-secretase and analysis of Alzheimer's disease.
PS1/γ-分泌酶的分子成像和阿尔茨海默病的分析。
- 批准号:
9901420 - 财政年份:2019
- 资助金额:
$ 25.06万 - 项目类别:
Epigenetic Mechanisms in Alcohol Use Disorder quantified by non-invasive PET imaging
通过非侵入性 PET 成像量化酒精使用障碍的表观遗传机制
- 批准号:
9751682 - 财政年份:2016
- 资助金额:
$ 25.06万 - 项目类别:
Epigenetic Mechanisms in Alcohol Use Disorder quantified by non-invasive PET imaging
通过非侵入性 PET 成像量化酒精使用障碍的表观遗传机制
- 批准号:
9168787 - 财政年份:2016
- 资助金额:
$ 25.06万 - 项目类别:
Epigenetic Mechanisms in Alcohol Use Disorder quantified by non-invasive PET imaging
通过非侵入性 PET 成像量化酒精使用障碍的表观遗传机制
- 批准号:
9975088 - 财政年份:2016
- 资助金额:
$ 25.06万 - 项目类别:
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