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Investigation of sirtuin 1 expression in mice model of Alzheimer's disease over age

随年龄增长的阿尔茨海默病小鼠模型中去乙酰化酶 1 表达的研究

基本信息

批准号：
10407173
负责人：
Changning Wang
金额：
$ 32.38万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2024-05-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10407173
关键词：
Acetyltransferase Address Adenine Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease brain Alzheimer&apos s disease model Alzheimer&apos s disease patient Amyotrophic Lateral Sclerosis Animal Disease Models Animal Model Animals Binding Brain Brain Diseases Bromodomain Cellular biology Central Nervous System Diseases Cessation of life Clinical Trials Coin Complex Couples DNA Sequence Data Dementia Development Differentiation and Growth Disease Disease Progression Drug abuse Elderly Electron Transport Enzymes Epigenetic Process FDA approved Family Functional disorder Genome Goals Growth and Development function Heart Diseases Histone Deacetylase Histones Human Huntington Disease Imaging Device Imaging Techniques In Vitro Investigation Investigative Techniques Kinetics Lead Life Longevity Lysine Malignant Neoplasms Measurement Measures Medical Research Metabolic Methods Modification Molecular Molecular Probes Mus Nature Neurodegenerative Disorders Niacinamide Parkinson Disease Pathologic Pathology Persons Pharmaceutical Preparations Physiological Play Positron-Emission Tomography Post-Translational Protein Processing Process Property Protein Family Proteins Reader Research Role SIRT1 gene Scientist Signal Transduction Sirtuins Specificity Tail Techniques Therapeutic Transgenic Animals United States Wild Type Mouse age related base biological adaptation to stress density design drug discovery effective therapy first-in-human healthy aging human imaging imaging agent imaging probe imaging study in vivo in vivo imaging interest man misfolded protein molecular imaging mouse model neuroimaging neuropathology non-invasive imaging novel novel therapeutics protein function sex small molecule therapeutics spinal and bulbar muscular atrophy technique development therapeutic development therapeutic target tool transcription factor uptake

项目摘要

Project Summary Sirtuin 1 has been implicated in multiple functions is thought as one of the candidate molecules for promoting healthy aging, because of its neuroprotective roles against several age-related pathologies, and several studies done in animals showed an association between sirtuin 1 and lifespan elongation. Sirtuin 1 has been shown to impact several brain disorders such as neurodegenerative disorders, such as Alzheimer’s disease. Therefore, it is important to have a tool for non-invasive measurement of sirtuin 1 expression and function in vivo, and PET imaging would be an ideal tool. Unfortunately, to date, there are no suitable non-invasive neuroimaging tools for investigating these processes in animals or in man until we developed the first PET imaging probe for sirtuin 1 recently. The development of techniques for visualizing sirtuin 1 in vivo represents a key step in understanding both the normal function and pathophysiology of sirtuin 1 in brain. Moreover, these techniques these techniques will accelerate the discovery/development of small molecule therapeutics that selectively interacts with sirtuin 1. The project is aimed to measure the expression of sirtuin 1 in brain of Alzheimer’s Disease animal model and wild-type mice over age, using our novel PET imaging probe, [11C]CWL-1, prior to first-in-human imaging.

项目总结