Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design

PrEP 摄取的功效

基本信息

  • 批准号:
    10273650
  • 负责人:
  • 金额:
    $ 82.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-08 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Background: Male sex workers (MSWs), or men who exchange sex for money, goods, drugs, or other items of value with other men, are at exceptionally high risk for HIV infection. Pre-exposure prophylaxis (PrEP) is effective at reducing HIV acquisition among HIV uninfected individuals, but its efficacy is highly dependent on uptake and excellent adherence. However, uptake of and adherence to PrEP among those who might benefit the most from using PrEP, such as MSWs, remains suboptimal. A successful PrEP uptake and adherence package must be responsive and tailored to MSWs’ distinct psychosocial and contextual circumstances. Overview of Proposal: The current proposal is a culmination of over 10 years of research with this population, including qualitative research, epidemiological assessments and programmatic work. These formative data led to an NIMH-funded R34 (MPIs: Biello, Mimiaga, Chan), which allowed our interdisciplinary team and community partners to collaborate on the development and pilot testing of a theory-based intervention— “PrEPare for Work”—to address 1) access to and uptake of PrEP at local PrEP clinics/providers via strength- based case management using principles of motivational interviewing (e.g., focusing on values, strengths and change efforts, making reflective and empathetic statements), and 2) provide cognitive-behavioral therapy- informed PrEP adherence counseling (e.g., problem-solving skill-building) with personalized, daily text message reminders to optimize PrEP adherence among MSWs. The pilot RCT demonstrated the feasibility, acceptability and preliminary efficacy of “PrEPare for Work”. Conceptual Model: The “PrEPare for Work” intervention is based on Social Cognitive Therapy (SCT), which specifies a core set of mechanisms that influence health behavior with a primary emphasis on self-regulation and self-reflection, including self-efficacy. Overview of Study Design: We now propose to test the efficacy of the “PrEPare for Work” package in the Greater Providence area and in Los Angeles County using a two-stage randomization design. Stage 1: 500 MSW will be equally randomized to receive either the “PrEPare for Work Stage 1 intervention” (strength-based case management and facilitated PrEP linkage) or standard of care to evaluate successful PrEP uptake (verified by real-time tenofovir urinalysis; prescription data) within 2 months. Stage 2: those who initiate PrEP (n~156; ~55% from Stage 1 intervention arm and ~20% from Stage 1 SOC arm) will be equally re-randomized to the “PrEPare for Work Stage 2 intervention” (1-on-1 skills training, problem solving, and motivational interviewing adherence counseling and personalized, daily text messaging reminders) or SOC to assess PrEP adherence (tenofovir concentration in hair sample) and retention in PrEP care (appointments attended) over 12 months. We will also examine the degree to which improvements in PrEP uptake and adherence occur in the context of the conceptual mediators (e.g., PrEP motivation, self-efficacy) and moderators (e.g., race/ethnicity, substance use, perceived HIV risk) of the intervention. Intervention cost-effectiveness will be assessed.
项目总结/文摘

项目成果

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Katie Brooks Biello其他文献

Katie Brooks Biello的其他文献

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{{ truncateString('Katie Brooks Biello', 18)}}的其他基金

Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil
为巴西的性少数群体和性别少数青年提供普遍、免费的抗逆转录病毒治疗
  • 批准号:
    10612852
  • 财政年份:
    2021
  • 资助金额:
    $ 82.82万
  • 项目类别:
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PrEP 摄取的功效
  • 批准号:
    10598594
  • 财政年份:
    2021
  • 资助金额:
    $ 82.82万
  • 项目类别:
Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil
为巴西的性少数群体和性别少数青年提供普遍、免费的抗逆转录病毒治疗
  • 批准号:
    10274560
  • 财政年份:
    2021
  • 资助金额:
    $ 82.82万
  • 项目类别:
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PrEP 摄取的功效
  • 批准号:
    10447813
  • 财政年份:
    2021
  • 资助金额:
    $ 82.82万
  • 项目类别:
Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil
为巴西的性少数群体和性别少数青年提供普遍、免费的抗逆转录病毒治疗
  • 批准号:
    10396669
  • 财政年份:
    2021
  • 资助金额:
    $ 82.82万
  • 项目类别:
Developing and Pilot Testing an Adaptive Intervention to Facilitate PrEP Uptake and Maximize PrEP Adherence among At-Risk Transgender Women
开发并试点测试适应性干预措施,以促进高危跨性别女性对 PrEP 的吸收并最大限度地提高 PrEP 的依从性
  • 批准号:
    10414059
  • 财政年份:
    2020
  • 资助金额:
    $ 82.82万
  • 项目类别:
Developing and Pilot Testing an Adaptive Intervention to Facilitate PrEP Uptake and Maximize PrEP Adherence among At-Risk Transgender Women
开发并试点测试适应性干预措施,以促进高危跨性别女性对 PrEP 的吸收并最大限度地提高 PrEP 的依从性
  • 批准号:
    10082543
  • 财政年份:
    2020
  • 资助金额:
    $ 82.82万
  • 项目类别:
Developing and Pilot Testing an Adaptive Intervention to Facilitate PrEP Uptake and Maximize PrEP Adherence among At-Risk Transgender Women
开发并试点测试适应性干预措施,以促进高危跨性别女性对 PrEP 的吸收并最大限度地提高 PrEP 的依从性
  • 批准号:
    10239233
  • 财政年份:
    2020
  • 资助金额:
    $ 82.82万
  • 项目类别:
Optimizing PrEP uptake & Adherence among MSWs using a 2-stage randomization design
优化 PrEP 的吸收
  • 批准号:
    9145451
  • 财政年份:
    2016
  • 资助金额:
    $ 82.82万
  • 项目类别:
Optimizing PrEP uptake & Adherence among MSWs using a 2-stage randomization design
优化 PrEP 的吸收
  • 批准号:
    9565054
  • 财政年份:
    2016
  • 资助金额:
    $ 82.82万
  • 项目类别:

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  • 批准号:
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针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
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利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
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利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
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Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
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