Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil
为巴西的性少数群体和性别少数青年提供普遍、免费的抗逆转录病毒治疗
基本信息
- 批准号:10274560
- 负责人:
- 金额:$ 22.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:19 year oldAddressAdherenceAgeAgreementAnti-Retroviral AgentsAppointmentAttentionBehavioralBehavioral ModelBisexualBrazilCaringChargeClinicCognitiveCommunitiesCounselingCuesDataDevelopmentDoseEnsureFaceFeedbackFocus GroupsFosteringFundingFutureGaysGoalsHIVHIV InfectionsHIV SeropositivityHealthHealthy EatingHourIncidenceIndividualInstitutesInterventionInterviewMeasuresMediator of activation proteinMedicalMedical RecordsMethodsMoodsMorbidity - disease rateMotivationNational Institute of Mental HealthOutcomeParticipantPatient Self-ReportPatientsPharmaceutical PreparationsPharmacy facilityPhasePlasmaPopulationPopulation InterventionPrevalencePreventionProblem SolvingProceduresProcessProviderQualitative ResearchRandomizedRandomized Controlled TrialsRecordsReportingResearchRiskSelf EfficacyServicesSexual TransmissionSexual and Gender MinoritiesSexual and Gender Minority YouthSocial supportStandardizationStructureTechnologyTestingText MessagingTheoretical modelTimeTransportationTravelViralViral Load resultWorkYouthagedantiretroviral therapyarmbaseefficacy trialexperiencegroup counselinggroup interventionimprovedimproved outcomeinformantmenmortalitypilot trialpost interventionpre-exposure prophylaxisprimary outcomeprogramsrecruitservice organizationside effectskillssocialsocial stigmastandard of caresubstance usetheoriestherapy adherencetherapy developmenttransgender womentransmission processtreatment adherencetreatment program
项目摘要
Background. Sexual and gender minority (SGM) youth account for the largest number of incident HIV
infections in Brazil. Although HIV can be managed with ongoing antiretroviral therapy (ART), exceptionally high
levels of adherence are required. Brazil has implemented a comprehensive HIV treatment program with broad
access to ART, but this program does not specifically address barriers to optimal ART adherence, particularly
for SGM youth who experience many challenges taking their medication as prescribed. Overview. This
application seeks to develop and pilot test a theory-based, integrated technology and counseling intervention
to improve ART adherence among HIV infected SGM youth (ages 15-24) in Rio de Janeiro, Brazil. The
intervention aims to improve social support, self-efficacy for taking ART, and teach skills for problem-solving
barriers to promote better adherence. To inform the content, structure, and format of the proposed intervention,
the MPIs recently conducted focus groups with SGM youth (N = 18) and key informant interviews (N = 7) with
medical providers and staff at local HIV service organizations working closely with SGM youth in Rio de
Janeiro. Across focus groups and key informant interviews there was universal agreement that an intervention
should capitalize on and enhance social support structures among SGM youth, and address their specific
concerns, especially as related to the individual (e.g., ART side effects, mood, substance use), social (e.g.,
HIV/SGM stigma), and structural (e.g., clinic hours, transportation challenges) barriers that they regularly face.
Theoretical Model. The intervention is guided by Social Cognitive and Social Support Theories and is
grounded in the social and contextual realities of SGM youth living with HIV in Brazil. Specifically, social
support is emphasized and informational, problem-solving and cognitive-behavioral “steps” are addressed over
4-group adherence counseling sessions, which include short video vignettes that seek to normalize adherence
challenges. In addition, daily tailored SMS text messages are delivered as part of the intervention to facilitate
social-cognitive cues to take medications as prescribed. Research Plan. Phase 1: Refine and enhance
participant acceptability of the intervention and resolve any issues with intervention delivery/implementation;
this will be achieved by convening and obtaining feedback from our youth community advisory board
throughout this phase and subsequent phases; and by conducting an open-phase pilot with up to 12 SGM
youth, with post-intervention exit interviews, as well as obtaining feedback from our youth community advisory
board throughout this and subsequent phases. Phase 2: Examine, in a pilot randomized controlled trial, the
feasibility, acceptability and potential impact of the proposed intervention among 72 SGM youth who will be
equally randomized to the intervention or a time- and attention-matched control condition with standard of care.
The outcomes are improved ART adherence (Wisepill, pharmacy assessment and self-report), retention in
care and viral load suppression. Study assessments will be conducted at baseline, 3- and 6-months.
背景。性和性别少数群体(SGM)青年是感染艾滋病毒人数最多的群体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Katie Brooks Biello其他文献
Katie Brooks Biello的其他文献
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{{ truncateString('Katie Brooks Biello', 18)}}的其他基金
Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil
为巴西的性少数群体和性别少数青年提供普遍、免费的抗逆转录病毒治疗
- 批准号:
10612852 - 财政年份:2021
- 资助金额:
$ 22.78万 - 项目类别:
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PrEP 摄取的功效
- 批准号:
10598594 - 财政年份:2021
- 资助金额:
$ 22.78万 - 项目类别:
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PrEP 摄取的功效
- 批准号:
10273650 - 财政年份:2021
- 资助金额:
$ 22.78万 - 项目类别:
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PrEP 摄取的功效
- 批准号:
10447813 - 财政年份:2021
- 资助金额:
$ 22.78万 - 项目类别:
Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil
为巴西的性少数群体和性别少数青年提供普遍、免费的抗逆转录病毒治疗
- 批准号:
10396669 - 财政年份:2021
- 资助金额:
$ 22.78万 - 项目类别:
Developing and Pilot Testing an Adaptive Intervention to Facilitate PrEP Uptake and Maximize PrEP Adherence among At-Risk Transgender Women
开发并试点测试适应性干预措施,以促进高危跨性别女性对 PrEP 的吸收并最大限度地提高 PrEP 的依从性
- 批准号:
10414059 - 财政年份:2020
- 资助金额:
$ 22.78万 - 项目类别:
Developing and Pilot Testing an Adaptive Intervention to Facilitate PrEP Uptake and Maximize PrEP Adherence among At-Risk Transgender Women
开发并试点测试适应性干预措施,以促进高危跨性别女性对 PrEP 的吸收并最大限度地提高 PrEP 的依从性
- 批准号:
10082543 - 财政年份:2020
- 资助金额:
$ 22.78万 - 项目类别:
Developing and Pilot Testing an Adaptive Intervention to Facilitate PrEP Uptake and Maximize PrEP Adherence among At-Risk Transgender Women
开发并试点测试适应性干预措施,以促进高危跨性别女性对 PrEP 的吸收并最大限度地提高 PrEP 的依从性
- 批准号:
10239233 - 财政年份:2020
- 资助金额:
$ 22.78万 - 项目类别:
Optimizing PrEP uptake & Adherence among MSWs using a 2-stage randomization design
优化 PrEP 的吸收
- 批准号:
9145451 - 财政年份:2016
- 资助金额:
$ 22.78万 - 项目类别:
Optimizing PrEP uptake & Adherence among MSWs using a 2-stage randomization design
优化 PrEP 的吸收
- 批准号:
9565054 - 财政年份:2016
- 资助金额:
$ 22.78万 - 项目类别:
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