Alternating Current Electrolysis for Organic Synthesis

有机合成交流电解

• 批准号: 10273248
• 负责人: Long Luo
• 金额: $ 34.75万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10273248
• 关键词: Chemicals; Chemistry; Drug Industry; Drug usage; Electricity; Electrolyses; Electrolytes; Electrons; Engineering; Environment; Goals; Libraries; Methodology; Methods; Organic Synthesis; Oxidation-Reduction; Pharmacologic Substance; Power Sources; Production; Reaction; Safety; Vision; chemical reaction; cost; drug synthesis; voltage; wasting

PROJECT SUMMARY With growing concerns regarding the environment and sustainability, there is an increasing demand for integrating green chemistry and green engineering into the pharmaceutical industry. Electrochemical organic synthesis represents a green and advantageous alternative to traditional synthetic methods because it directly uses electrons from a power source to complete the redox transformations, which can cut down on the usage of chemicals, reduce waste, and offer improvements in cost, safety, and sustainability. However, the current reaction library of electrosynthetic methods is limited. Therefore, there is a critical need for new electrolytic methods that offer new chemical reactivities. The proposal is focused on studying the mostly unexplored alternating current electrolysis for organic synthesis. Unlike the conventional electroorganic synthetic methods using a constant voltage or current, alternating current electrolysis uses an alternating voltage to drive the redox transformations of substrates. Alternating current electrolysis offers a unique reaction environment where two redox-opposite reactions can occur spatially and temporally close to each other and can be easily adjustable by merely controlling the alternating current voltage supply. The overall goal of this proposal is to exploit this unique reaction environment of alternating current electrolysis to achieve new reactivities that are not currently accessible by the existing synthetic methodologies, serving as a critical step towards the long-term vision of the electrically driven green synthesis of drugs.

项目总结 随着人们对环境和可持续性的日益关注，有越来越多的 将绿色化学和绿色工程融入制药行业的需求。 电化学有机合成是传统有机合成的一种绿色、有利的替代方法 合成方法，因为它直接使用来自电源的电子来完成氧化还原 转型，这可以减少化学品的使用，减少浪费，并提供 提高了成本、安全性和可持续性。然而，目前的反应文库 电合成方法是有限的。因此，迫切需要新的电解方法。 提供了新的化学反应。 该提案的重点是研究最未探索的交流电解法 有机合成。不同于传统的电有机合成方法，使用常量 电压或电流，交流电解使用交流电压来驱动氧化还原 底物的变换。交流电解提供了一种独特的反应 两个氧化还原相反的反应可以在空间和时间上靠近每个反应的环境 其他，只需控制交流电压电源即可方便地进行调节。 这项提议的总体目标是利用这种独特的反应环境 电流电解以实现新的反应性，这是现有的 综合方法论，作为迈向电子技术长期愿景的关键一步 推动药物绿色合成。