Inflammation-Induced CNS Glutamate as a Function of Depression in Middle Age

项目总结 目标和目标与父应用程序中提出的目标相似。简而言之，我们计划测量1)中枢神经系统 使用单体素和化学位移的谷氨酸，多体素，MRS，2)微结构白质完整性 使用扩散张量成像/基于轨迹的空间统计和髓鞘映射，3)周围和中央 65例未用药的抑郁症患者的炎症和抑郁症状及认知的生物标志物 35名年龄在35-65岁的对照组。已经对80名受试者(55名抑郁症患者，25名对照组)进行了研究。我们 建议支持再招募10名抑郁症受试者和10名对照受试者。 与这一要求相关的问题：我们的研究在2020年3月至9月期间面临关闭 由于新冠肺炎相关关停。然而，由于可以理解的原因，所有工作人员的工资都已全额支付 和富有同情心的理由。我们要求收回过去7个月支付的工资并重新启动成本。 这项研究的全部影响可以通过增加20名患者来充分实现-结果 在100个完井样本中。我们提供了支持这一结论的权力分析。

PROJECT SUMMARY The aims and goals are similar to those proposed in the parent application. Briefly, we plan to measure 1) CNS glutamate using single voxel and chemical-shift, multivoxel, MRS, 2) microstructural white matter integrity using diffusion tensor imaging/tract-based spatial statistics and myelin mapping, 3) peripheral and central biomarkers of inflammation and 4) depressive symptoms and cognition in 65 medication-free depressed and 35 controls aged 35-65. A sample of 80 subjects (55 depressed, 25 controls) have already been studied. We propose support to recruit 10 more depressed and 10 more controlled subjects. Issues specific to this request: Our study has faced closure between the months of March-September 2020 due to COVID-19-related shutdown. However, all staff salaries have been paid in full due to understandable and compassionate reasons. We request recouping the salary paid for the past 7 months and restart up costs. The full impact of the study could be fully realized by augmenting the sample with 20 more patients – resulting in a completion sample of 100. We have provided power analysis in support of this conclusion.