Inflammation-Induced CNS Glutamate as a Function of Depression in Middle Age

炎症引起的中枢神经系统谷氨酸与中年抑郁症的关系

• 批准号: 10273670
• 负责人: Ebrahim Haroon
• 金额: $ 12.91万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10273670
• 关键词: Aging; Anisotropy; Anterior; Axon; Basal Ganglia; Behavior; Behavior assessment; Behavioral; Biological Markers; Brain; Brain region; Brain-Derived Neurotrophic Factor; C-reactive protein; COVID-19; Cerebrospinal Fluid; Chemical Shift Imaging; Chemicals; Chronic; Cognition; Creatine; Cytokine Receptors; Data; Dementia; Depressed mood; Diffuse; Diffusion Magnetic Resonance Imaging; Exhibits; Funding; Glutamates; Goals; Hippocampus (Brain); Impairment; Individual; Inflammation; Inflammatory; Internal Capsule; Lead; Light; Measures; Mental Depression; Myelin; Neurons; Parents; Pathology; Patients; Performance; Peripheral; Pharmaceutical Preparations; Plasma; Proteins; ROC Curve; Radial; Research; Sampling; Sensitivity and Specificity; TNF gene; Testing; Time; Wages; aged; base; cingulate cortex; cognitive function; cognitive performance; cognitive task; cost; cytokine; depressed patient; depressive cognitions; depressive symptoms; extracellular; indexing; middle age; neurofilament; parent project; power analysis; recruit; statistics; tractography; white matter

PROJECT SUMMARY The aims and goals are similar to those proposed in the parent application. Briefly, we plan to measure 1) CNS glutamate using single voxel and chemical-shift, multivoxel, MRS, 2) microstructural white matter integrity using diffusion tensor imaging/tract-based spatial statistics and myelin mapping, 3) peripheral and central biomarkers of inflammation and 4) depressive symptoms and cognition in 65 medication-free depressed and 35 controls aged 35-65. A sample of 80 subjects (55 depressed, 25 controls) have already been studied. We propose support to recruit 10 more depressed and 10 more controlled subjects. Issues specific to this request: Our study has faced closure between the months of March-September 2020 due to COVID-19-related shutdown. However, all staff salaries have been paid in full due to understandable and compassionate reasons. We request recouping the salary paid for the past 7 months and restart up costs. The full impact of the study could be fully realized by augmenting the sample with 20 more patients – resulting in a completion sample of 100. We have provided power analysis in support of this conclusion.

项目摘要 目的和目标与母申请中提出的目标和目标相似。简而言之，我们计划测量1）CNS 使用单体素和化学位移、多体素、MRS的谷氨酸盐，2）显微结构白色物质完整性 使用扩散张量成像/基于束的空间统计和髓鞘映射，3）外周和中央 炎症的生物标志物和4）抑郁症状和认知在65个无药物治疗的抑郁症和 35例对照，年龄35-65岁。80名受试者（55名抑郁症患者，25名对照组）的样本已经进行了研究。我们 建议支持招募10名抑郁和10名控制受试者。 此请求的特定问题：我们的研究在2020年3月至9月期间面临关闭 由于COVID-19相关的关闭。然而，由于可以理解的原因，所有工作人员的工资都已全额支付。 出于同情的原因。我们要求收回过去7个月的工资，并重新启动成本。 研究的全部影响可以通过增加20名患者的样本来充分实现-结果 在100个完成样本中。我们提供了功效分析来支持这一结论。