Pediatric brain tumors: Improving survival through integration of clinical molecular diagnostics and biologically targeted therapies into clinical trials

儿科脑肿瘤：通过将临床分子诊断和生物靶向治疗整合到临床试验中来提高生存率

• 批准号: 10563032
• 负责人: Sarah Elisabeth Sherr Leary
• 金额: $ 17.53万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-21 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10563032
• 关键词: Acceleration; Award; Biological; Brain; Brain Neoplasms; Cancer Etiology; Central Nervous System; Central Nervous System Neoplasms; Child; Childhood; Childhood Brain Neoplasm; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Network; Data; Development; Disease; Enrollment; Equity; Funding; Goals; Infrastructure; Institution; International; Leadership; Malignant Childhood Neoplasm; Malignant Neoplasms; Molecular; Morbidity - disease rate; National Clinical Trials Network; Operations Research; Pediatric Hospitals; Pediatric Oncology Group; Phase; Physician Executives; Principal Investigator; Qualifying; Registries; Research; Role; Scientist; Site; Time; Translating; Translational Research; Treatment-related toxicity; Tumor Bank; Tumor Biology; United States National Institutes of Health; Work; anticancer research; childhood cancer mortality; clinical trial implementation; data sharing; early phase clinical trial; experience; genomic data; improved; insight; molecular diagnostics; next generation; novel therapeutics; programs; risk stratification; targeted treatment

PROJECT SUMMARY/ABSTRACT: Tumors of the central nervous system (CNS) are the leading cause of cancer death in children. Many of those who do survive suffer from significant lifelong morbidity due to toxicity of therapy. There is an urgent need to improve survival and decrease toxicity of therapy in children with brain tumors. My research focus is to improve survival for children with CNS tumors through the development of novel therapeutics and clinical trials based on biologic insights into the molecular drivers of disease. I conduct my research through collaborative studies that are made possible by the National Clinical Trials Network (NCTN), specifically the Children’s Oncology Group (COG). Nationally, I serve in a leadership role as the clinical vice-chair of the COG CNS committee, COG representative to the NIH Brain Malignancies Steering Committee (BMSC), and CNS representative to the Agent Prioritization Committee (APC) of the NIH-funded Pediatric Early Phase Clinical Trials Network (PEP-CTN). I have also recently led the creation of a data-sharing initiative called the INSPiRE consortium which aims to facilitate clinical trials and genomic data sharing between the COG and other international clinical trials consortia and registries. Locally, I serve as the Seattle Children’s Hospital site PI for COG, Medical Director of Clinical Research for the Seattle Children’s Ben Towne Center for Childhood Cancer Research, Principal Investigator of the Seattle Children’s Tumor Banking and Biology Study, and Medical Director of the Pediatric Brain Tumor Program. These complementary national and local roles allow me to provide support to a wide range of translational and clinical research efforts, providing access to all phases of research to children in Seattle and translating research discovery in Seattle to children across the world through the development of collaborative clinical trials. The opportunities afforded by this award would allow me to devote significant time to accelerate the development of high-impact clinical trials and to support critical efforts to improve molecular and clinical data sharing and local access to trials.

项目总结/文摘: