Engineering the Skin Immune System to Induce Systemic Immune Responses
改造皮肤免疫系统以诱导全身免疫反应
基本信息
- 批准号:10561663
- 负责人:
- 金额:$ 66.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-04 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAddressAdjuvantAgeAntibodiesAntibody ResponseAntigen-Presenting CellsAntigensBiologyBronchoalveolar LavageCD8-Positive T-LymphocytesCOVID-19COVID-19 vaccineCell physiologyCellular ImmunityClinicalClinical TrialsCombined VaccinesCutaneousDataDermatologyDevelopmentDiseaseDoseElderlyEngineered skinEngineeringFundingGenerationsGoalsHealthHumanImmuneImmune responseImmune systemImmunityImmunizationImmunobiologyImmunologicsImmunomodulatorsIn SituInflammatoryInjectionsInnate Immune ResponseLearningLongevityLungLymphoid TissueMethodsMusNatural ImmunityNeedlesOrganPhase I/II Clinical TrialPredispositionPreventionProtein SubunitsPublishingRegulationReproducibilitySARS-CoV-2 antigenSARS-CoV-2 immunitySafetySkinSkin AgingSkin CancerSpleenSubunit VaccinesT-LymphocyteTranslationsUnited States National Institutes of HealthVaccinationVaccinesadaptive immune responseagedbiomarker identificationclinical applicationclinical translationdesigndraining lymph nodeexperienceimmune functionimmunoengineeringimmunogenicityimmunoregulationimmunosenescenceimprovedinnate immune mechanismsneutralizing antibodynext generationnovelpathogenperipheral bloodrational designtargeted deliverytechnology platformtranslational studyvaccination strategyvaccine deliveryvaccine developmentvaccine efficacyvaccine response
项目摘要
PROJECT SUMMARY / ABSTRACT:
The skin functions as a potent immune organ, rendering the readily accessible cutaneous
microenvironment an attractive target that can be locally engineered to induce and regulate
systemic immune responses. Increasing age is associated with changes in immune function
(immunosenescence) that result in increased susceptibility to diseases and poor vaccine
responses in older adults. This proposal is designed to bring together very recent and significant
advances in dermatology and skin biology to address critical problems in human health. Here, we
specifically focus on the skin microenvironment and strategies for cutaneous immunomodulation.
The overall approach is to utilize a clinically applicable dissolvable microneedle array delivery
platform we have developed to locally engineer the highly adaptive and immunoresponsive skin
microenvironment. Specifically, we propose to modulate local immune regulatory circuits in the
skin to enable the induction and regulation of systemic immune responses. The studies we
propose will investigate the effect of locally delivered immune modulators on the mechanisms
underlying cutaneous immune regulation in young and aged skin. Importantly, our studies include
translational studies using living human skin to enable the rapid advancement of novel cutaneous
immunomodulation strategies into clinical trials. The proposed studies will result in a better
understanding of skin immunobiology specifically relevant to the development of safe and
predictable skin immunoengineering strategies to regulate systemic immune responses across
the lifespan.
项目摘要/摘要:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Louis D Falo', 18)}}的其他基金
Multiscale, Multimodal Analysis of Skin and Spatial Cell Organization
皮肤和空间细胞组织的多尺度、多模式分析
- 批准号:
10708913 - 财政年份:2022
- 资助金额:
$ 66.25万 - 项目类别:
Multiscale, Multimodal Analysis of Skin and Spatial Cell Organization
皮肤和空间细胞组织的多尺度、多模式分析
- 批准号:
10530827 - 财政年份:2022
- 资助金额:
$ 66.25万 - 项目类别:
Engineering the Skin Immune System to Induce Systemic Immune Responses
改造皮肤免疫系统以诱导全身免疫反应
- 批准号:
10363729 - 财政年份:2021
- 资助金额:
$ 66.25万 - 项目类别:
Project 3: Localized microneedle-directed combination immunotherapy for cSCC
项目3:局部微针定向联合免疫治疗cSCC
- 批准号:
10469637 - 财政年份:2021
- 资助金额:
$ 66.25万 - 项目类别:
Project 3: Localized microneedle-directed combination immunotherapy for cSCC
项目3:局部微针定向联合免疫治疗cSCC
- 批准号:
10683759 - 财政年份:2021
- 资助金额:
$ 66.25万 - 项目类别:
Project 3: Localized microneedle-directed combination immunotherapy for cSCC
项目3:局部微针定向联合免疫治疗cSCC
- 批准号:
10270233 - 财政年份:2021
- 资助金额:
$ 66.25万 - 项目类别:
Engineering the Skin Microenvironment to Promote Allergen Tolerance
改造皮肤微环境以促进过敏原耐受性
- 批准号:
9753923 - 财政年份:2018
- 资助金额:
$ 66.25万 - 项目类别:
Engineering the Skin Microenvironment to Promote Allergen Tolerance
改造皮肤微环境以促进过敏原耐受性
- 批准号:
10613869 - 财政年份:2018
- 资助金额:
$ 66.25万 - 项目类别:
MNA Delivery of Neurokinin 1 Receptor Antagonists to Treat Atopic Dermatitis
MNA 递送神经激肽 1 受体拮抗剂治疗特应性皮炎
- 批准号:
10171787 - 财政年份:2017
- 资助金额:
$ 66.25万 - 项目类别:
Manipulating Cutaneous Neuroimmunity to Treat Contact Dermatitis
操纵皮肤神经免疫治疗接触性皮炎
- 批准号:
9302683 - 财政年份:2015
- 资助金额:
$ 66.25万 - 项目类别:
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