Engineering the Skin Immune System to Induce Systemic Immune Responses

改造皮肤免疫系统以诱导全身免疫反应

基本信息

  • 批准号:
    10561663
  • 负责人:
  • 金额:
    $ 66.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-03-04 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY / ABSTRACT: The skin functions as a potent immune organ, rendering the readily accessible cutaneous microenvironment an attractive target that can be locally engineered to induce and regulate systemic immune responses. Increasing age is associated with changes in immune function (immunosenescence) that result in increased susceptibility to diseases and poor vaccine responses in older adults. This proposal is designed to bring together very recent and significant advances in dermatology and skin biology to address critical problems in human health. Here, we specifically focus on the skin microenvironment and strategies for cutaneous immunomodulation. The overall approach is to utilize a clinically applicable dissolvable microneedle array delivery platform we have developed to locally engineer the highly adaptive and immunoresponsive skin microenvironment. Specifically, we propose to modulate local immune regulatory circuits in the skin to enable the induction and regulation of systemic immune responses. The studies we propose will investigate the effect of locally delivered immune modulators on the mechanisms underlying cutaneous immune regulation in young and aged skin. Importantly, our studies include translational studies using living human skin to enable the rapid advancement of novel cutaneous immunomodulation strategies into clinical trials. The proposed studies will result in a better understanding of skin immunobiology specifically relevant to the development of safe and predictable skin immunoengineering strategies to regulate systemic immune responses across the lifespan.
项目摘要/摘要:

项目成果

期刊论文数量(0)
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Louis D Falo其他文献

Louis D Falo的其他文献

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{{ truncateString('Louis D Falo', 18)}}的其他基金

Multiscale, Multimodal Analysis of Skin and Spatial Cell Organization
皮肤和空间细胞组织的多尺度、多模式分析
  • 批准号:
    10708913
  • 财政年份:
    2022
  • 资助金额:
    $ 66.25万
  • 项目类别:
Multiscale, Multimodal Analysis of Skin and Spatial Cell Organization
皮肤和空间细胞组织的多尺度、多模式分析
  • 批准号:
    10530827
  • 财政年份:
    2022
  • 资助金额:
    $ 66.25万
  • 项目类别:
Engineering the Skin Immune System to Induce Systemic Immune Responses
改造皮肤免疫系统以诱导全身免疫反应
  • 批准号:
    10363729
  • 财政年份:
    2021
  • 资助金额:
    $ 66.25万
  • 项目类别:
Project 3: Localized microneedle-directed combination immunotherapy for cSCC
项目3:局部微针定向联合免疫治疗cSCC
  • 批准号:
    10469637
  • 财政年份:
    2021
  • 资助金额:
    $ 66.25万
  • 项目类别:
Project 3: Localized microneedle-directed combination immunotherapy for cSCC
项目3:局部微针定向联合免疫治疗cSCC
  • 批准号:
    10683759
  • 财政年份:
    2021
  • 资助金额:
    $ 66.25万
  • 项目类别:
Project 3: Localized microneedle-directed combination immunotherapy for cSCC
项目3:局部微针定向联合免疫治疗cSCC
  • 批准号:
    10270233
  • 财政年份:
    2021
  • 资助金额:
    $ 66.25万
  • 项目类别:
Engineering the Skin Microenvironment to Promote Allergen Tolerance
改造皮肤微环境以促进过敏原耐受性
  • 批准号:
    9753923
  • 财政年份:
    2018
  • 资助金额:
    $ 66.25万
  • 项目类别:
Engineering the Skin Microenvironment to Promote Allergen Tolerance
改造皮肤微环境以促进过敏原耐受性
  • 批准号:
    10613869
  • 财政年份:
    2018
  • 资助金额:
    $ 66.25万
  • 项目类别:
MNA Delivery of Neurokinin 1 Receptor Antagonists to Treat Atopic Dermatitis
MNA 递送神经激肽 1 受体拮抗剂治疗特应性皮炎
  • 批准号:
    10171787
  • 财政年份:
    2017
  • 资助金额:
    $ 66.25万
  • 项目类别:
Manipulating Cutaneous Neuroimmunity to Treat Contact Dermatitis
操纵皮肤神经免疫治疗接触性皮炎
  • 批准号:
    9302683
  • 财政年份:
    2015
  • 资助金额:
    $ 66.25万
  • 项目类别:

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