Core E Research Support
Core E Research Support
批准号:
10560522
负责人:
RUI-MING LIU
金额:
$7.76万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-03-15 至 2025-01-31
关键词:
AdultAffectAfrican AmericanAirAnimal ModelAnimalsAnnual ReportsAreaArsenicAsthmaAuthorization documentationBioinformaticsBiologicalBiological ProcessBronchoalveolar LavageCadmiumChronicChronic Obstructive Pulmonary DiseaseClinicalClinical DataClinical ResearchCollaborationsCommunitiesCountyData AnalysesData CollectionDatabasesDustEligibility DeterminationEnrollmentEnsureEnvironmentEnvironmental ExposureExposure toFutureGoalsHeavy MetalsHigh PrevalenceHumanHuman ResourcesIACUCIndividualIndustrializationInformed ConsentInfrastructureInhalationInhalation ExposureInstitutional Review BoardsInternationalKnowledge acquisitionLaboratoriesLifeLower Respiratory Tract InfectionLung diseasesLung infectionsManganeseMetal exposureMethodsMissionModelingMusNational Institute of Environmental Health SciencesPlasmaPoisonPollutionPopulationPostdoctoral FellowProceduresProcessProtocols documentationPublic HealthQuality ControlResearchResearch PersonnelResearch SupportResourcesRespiratory Tract InfectionsRoleSafetySamplingSecureServicesSignal Recognition ParticleSiteSocietiesSpecimenSpecimen HandlingStandardizationSuperfundTissue HarvestingTrainingTranslational ResearchUnited StatesVertebratesaerosolizedanimal facilitybiobankclinical centercommunity engagementdata managementexperiencehuman subjectinsightlung injurymouse modelorganizational structureprogramsrecruitsample collectionsexsuccesssynergism
中文摘要
摘要
由于数十年的重工业活动,北伯明翰地区已受到严重的污染
有毒化学物质,包括镉、砷和锰等重金属。人口在
拟议的北伯明翰国家优先事项清单 (NPL) 地点(受影响地区;邮政编码 35207 和 35217)
主要是非洲裔美国人,慢性阻塞性肺病 (COPD) 发病率较高,但慢性阻塞性肺疾病 (COPD) 发病率较低
与杰斐逊工业化程度较低的地区(控制区)相比,呼吸道感染 (LRTI) 和哮喘
县(邮政编码35214)。考虑到美国肺部疾病的高患病率,特别是
慢性阻塞性肺病、哮喘和呼吸道感染,拟议的研究与公共卫生相关。临床
生物样本库和动物暴露核心(核心 E)有两个具体目标: 具体目标 1:管理
身份识别、招募、知情同意流程、入组、临床数据收集和生物标本
从居住在受影响地区和控制地区的受试者那里收集;具体目标 2:暴露成年小鼠 (C57BL/6)
男性和女性接触砷、锰、镉或来自受影响和控制区域的现实生活过滤灰尘 4-6
三周内每天几个小时;老鼠将被转移到不同的项目,以便他们能够完成他们的提议
具体目标。临床生物样本库和动物暴露核心的活动对于整体而言至关重要
该超级基金计划的成功。人类标本的综合生物样本库将构成一个
独特的资源将进一步推动 NIEHS/超级基金的使命。此外,让小鼠接触重金属
环境空气中存在的浓度将创建一个模型来反映和概括
NPL 现场的环境暴露。核心人员将由经验丰富的肺科医生组成
在临床研究方面,毒理学家在小鼠吸入和肺损伤研究方面拥有丰富的经验,一项研究
协调员和研究员。核心活动将得到数据的紧密整合和支持
管理和分析核心 (DMAC)、社区参与核心 (CEC)、生物样本库基础设施
UAB 临床转化科学中心 (CCTS) 和 UAB 内的吸入暴露设施
动物设施。所有研究人员都必须满足并维持 UAB 的培训要求
IRB 和 IACUC。 IRB 和 IACUC 将审查并监督所有与研究相关的活动。
将制定程序以确保人类受试者的安全和脊椎动物的人道处理。的
UAB CCTS 生物样本库遵循国际协会定义的最佳实践,以确保经过验证和
为样本处理和样本完整性制定了可靠的程序和协议。集中式、
该核心的标准化和全面的专业知识和组织代表了基于价值的经济
为整个拟议中心所做的努力。
英文摘要
ABSTRACT
Due to decades of heavy industrial activity, the North Birmingham area has been severely polluted with
toxic chemicals including heavy metals such as cadmium, arsenic, and manganese. The population in the
proposed North Birmingham National Priorities List (NPL) site (Affected Areas; zip codes 35207 and 35217) is
predominantly African American and has higher rates of chronic obstructive pulmonary disease (COPD), lower
respiratory tract infection (LRTI), and asthma compared to less industrialized areas (Control Area) of Jefferson
County (zip code 35214). Considering the high prevalence of lung disease in the United States, particularly
COPD, asthma, and respiratory tract infections, the proposed research is relevant to public health. The Clinical
Biorepository and Animal Exposure Core (Core E) has two specific aims: Specific Aim 1: Manage the
identification, recruitment, informed consent process, enrollment, clinical data collection, and biological specimen
collection from subjects living in the Affected and Control Areas; Specific Aim 2: Expose adult mice (C57BL/6)
of both sexes to arsenic, manganese, cadmium or real-life filtered dust from Affected and Control Areas for 4-6
hrs per day for three weeks; mice will be transferred to various projects so they can complete their proposed
specific aims. The activities of the Clinical Biorepository and Animal Exposure Core will be essential to the overall
success of this Superfund Program. The comprehensive biorepository of human specimens would constitute a
unique resource that would further the NIEHS/Superfund mission. Furthermore, exposing mice to heavy metals
in concentrations that are present in ambient air will create a model that mirrors and recapitulates the
environmental exposures at the NPL site. The Core will be comprised of a pulmonologist with ample experience
in clinical research, a toxicologist with extensive experience in mouse inhalation and lung injury study, a research
coordinator, and a research associate. Core activities will be closely integrated and supported by the Data
Management and Analysis Core (DMAC), Community Engagement Core (CEC), the biorepository infrastructure
of the UAB Center for Clinical Translational Science (CCTS), and the Inhalation Exposure Facility within the UAB
Animal Facility. All research personnel will be required to fulfill and maintain the training requirements of the UAB
IRB and the IACUC. The IRB and the IACUC will review and provide oversight of all research-related activities.
Procedures will be in place to ensure safety of human subjects and humane handling of vertebrate animals. The
UAB CCTS Biorepository follows best practices defined by international societies to ensure that validated and
reliable procedures and protocols are in place for specimen handling and sample integrity. The centralized,
standardized and comprehensive expertise and organization of this Core represents a value-based, economy of
effort for the overall proposed center.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Sex-dependent synergy between O3 exposure, APOE4 e4 genotype, and aging in the onset of Alzheimer's disease
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批准号:10584765
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项目类别:
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资助金额:$44.14万
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财政年份:2023
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负责人:RUI-MING LIU
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依托单位:
Core E Research Support
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批准号:10337086
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项目类别:
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资助金额:$7.82万
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财政年份:2020
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负责人:RUI-MING LIU
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依托单位:
PAI-1 and aging-related susceptibility to lung fibrosis
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批准号:9336422
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项目类别:
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资助金额:$43.84万
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财政年份:2016
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负责人:RUI-MING LIU
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依托单位:
Ozone, apoE4, aging, and Alzheimer's disease
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批准号:8741923
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项目类别:
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资助金额:$18.38万
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财政年份:2013
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负责人:RUI-MING LIU
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依托单位:
Animal Core
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批准号:10218249
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项目类别:
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资助金额:$19.75万
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财政年份:2013
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负责人:RUI-MING LIU
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依托单位:
Ozone, apoE4, aging, and Alzheimer's disease
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批准号:8621919
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项目类别:
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资助金额:$22.04万
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财政年份:2013
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负责人:RUI-MING LIU
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依托单位:
Glutathione and Lung Fibrosis
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批准号:7895651
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项目类别:
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资助金额:$36.25万
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财政年份:2008
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负责人:RUI-MING LIU
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依托单位:
Glutathione and Lung Fibrosis
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批准号:7527229
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项目类别:
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资助金额:$34.9万
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财政年份:2008
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负责人:RUI-MING LIU
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依托单位:
Glutathione and Lung Fibrosis
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批准号:7691813
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项目类别:
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资助金额:$34.9万
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财政年份:2008
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负责人:RUI-MING LIU
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依托单位:
Glutathione deficiency & immune dysfunction during aging
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批准号:6830308
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项目类别:
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资助金额:$21.53万
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财政年份:2002
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负责人:RUI-MING LIU
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依托单位:
Glutathione deficiency & immune dysfunction during aging
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批准号:6621756
-
项目类别:
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资助金额:$21.53万
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财政年份:2002
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负责人:RUI-MING LIU
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依托单位:
Glutathione deficiency & immune dysfunction during aging
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批准号:6686002
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项目类别:
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资助金额:$21.53万
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财政年份:2002
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负责人:RUI-MING LIU
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依托单位:
Glutathione deficiency & immune dysfunction during aging
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批准号:6989757
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项目类别:
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资助金额:$21.02万
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财政年份:2002
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负责人:RUI-MING LIU
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依托单位:
Glutathione deficiency & immune dysfunction during aging
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批准号:6436397
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项目类别:
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资助金额:$24.03万
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财政年份:2002
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负责人:RUI-MING LIU
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依托单位:
GLUTAMYLCYSTEUBE SYNTHETASE AND AGING
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批准号:2705994
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项目类别:
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资助金额:$2.15万
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财政年份:1998
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负责人:RUI-MING LIU
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依托单位:
GLUTAMYLCYSTEUBE SYNTHETASE AND AGING
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批准号:6131813
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项目类别:
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资助金额:$6.05万
-
财政年份:1998
-
负责人:RUI-MING LIU
-
依托单位:
Animal and Therapeutics Core
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批准号:8735182
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项目类别:
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资助金额:$32.88万
-
财政年份:--
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负责人:RUI-MING LIU
-
依托单位:
Animal and Therapeutics Core
-
批准号:8582306
-
项目类别:
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资助金额:$31.94万
-
财政年份:--
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负责人:RUI-MING LIU
-
依托单位:
Animal Core
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批准号:9752653
-
项目类别:
-
资助金额:$19.75万
-
财政年份:--
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负责人:RUI-MING LIU
-
依托单位:
Animal and Therapeutics Core
-
批准号:9115707
-
项目类别:
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资助金额:$32.29万
-
财政年份:--
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负责人:RUI-MING LIU
-
依托单位:
海外基金