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Oxytocin Mediates Phasic and Tonic Dopamine Release

催产素介导阶段性和强直性多巴胺释放

基本信息

批准号：
10575856
负责人：
Deranda B Lester
金额：
$ 6.94万
依托单位：
UNIVERSITY OF MEMPHIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10575856
关键词：
Adult Affect Agonist Anesthesia procedures Attenuated Autoreceptors Brain region Cell Nucleus Cells Clinical Clinical Trials Complex Detection Diagnosis Dopamine Dopamine D2 Receptor Dopaminergic Cell Dose Drug usage Electrodes FDA approved Female Fire - disasters Future Gender Infusion procedures Location Mediating Mus Neuropeptides Nucleus Accumbens Outcome Oxytocin Oxytocin Receptor Pathway interactions Patients Pattern Periodicity Peripheral Pharmaceutical Preparations Pharmacologic Substance Phase Process Receptor Activation Recovery Relapse Research Rewards Scanning Site Social Behavior Socialization Stimulus Structure Substance Use Disorder System Techniques Therapeutic Therapeutic Effect Treatment outcome Ventral Tegmental Area addiction behavioral response biological adaptation to stress dopaminergic neuron drug abstinence drug reward experience improved in vivo male meetings mesolimbic system neural neural circuit neurochemistry novel programs psychostimulant response reward processing sex social stimulant use disorder substance use treatment

项目摘要

Project Summary Substance use disorder (SUD) is prevalent in the US with over 10% of adults fitting the criteria for diagnosis. Unfortunately, SUD treatments are often unsuccessful, with up to 75% of patients experiencing relapse. SUD is associated with problematic reward processing, leading to drug use at the expense of natural rewards and despite negative consequences. Addiction recovery programs often require drug abstinence while reinforcing engagement with natural rewards such as socialization. Research suggests that oxytocin administration could help with this process and improve treatment outcomes for SUD. Although the therapeutic potential of oxytocin is already being investigated in clinical trials with encouraging outcomes, the effects of oxytocin on reward- related neural circuits are not understood. The current proposal will assess the region-specific influence of oxytocin receptor activation on neurochemical release associated with drug and social reward processing. Most studies point to oxytocin decreasing the reinforcing effects of drugs but increasing the salience of social stimuli. The detection of rewarding stimuli is regulated in part by the mesolimbic dopamine system, with dopaminergic cell bodies in the ventral tegmental area (VTA) that project to the nucleus accumbens (NAc). Emerging evidence suggests that different circuits facilitate drug versus social reward, with drug reward depending on phasic (fast bursts) dopamine release and social reward on tonic (slow, steady) dopamine release in the NAc. Oxytocin’s therapeutic effects for addiction may be a result of oxytocin shifting dopamine release patterns from phasic to tonic, thus rebalancing the pathways facilitating drug and social reward. The proposed study will be the first to systematically investigate the neural regions in which oxytocin mediates phasic and tonic mesolimbic dopamine release. Using an established electrochemical technique (fast scan cyclic voltammetry), we will assess in vivo phasic and tonic dopamine release following microinfusions of a selective oxytocin receptor agonist into the NAc or VTA. Clarifying the mechanisms by which oxytocin mediates drug and social reward is crucial for harnessing the full therapeutical potential of oxytocin for SUD.

项目总结