Sleep and Circadian Contributions to Nighttime Blood Pressure Rhythms (SCN-BP)

睡眠和昼夜节律对夜间血压节律 (SCN-BP) 的影响

• 批准号: 10577473
• 负责人: Stephen J Thomas
• 金额: $ 61.18万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577473
• 关键词: Academic Medical Centers; Activities of Daily Living; Address; Age; Alabama; Ambulatory Blood Pressure Monitoring; Antihypertensive Agents; Behavior Therapy; Behavioral; Biological; Blood Pressure; Blood Pressure Monitors; Body Temperature; California; Cardiovascular Diseases; Cessation of life; Characteristics; Chronotherapy; Circadian Rhythms; Clinical; Clinical Sciences; Data; Detection; Development; Educational workshop; Ethnic Origin; Future; Home Blood Pressure Monitoring; Hour; Human; Hypertension; Intervention; Jet Lag Syndrome; Light; Los Angeles; Low Prevalence; Measurement; Melatonin; Morbidity - disease rate; National Heart, Lung, and Blood Institute; New York; Organ; Participant; Pattern; Persons; Pharmaceutical Preparations; Phase; Phenotype; Play; Population; Population Sciences; Posture; Prevalence; Protocols documentation; Questionnaires; Race; Research; Role; Salivary; Sampling; Site; Sleep; Sleep Fragmentations; Strategic Planning; System; Time; Universities; Wrist; actigraphy; age difference; awake; blood pressure control; blood pressure reduction; cardiovascular disorder risk; circadian; cohort; design; feeding; improved; mortality; participant enrollment; precision medicine; prevent; primary outcome; secondary outcome; sex; shift work; sleep behavior; social; therapy development

Project Summary High asleep systolic blood pressure (SBP) and a non-dipping blood pressure (BP) pattern (a <10% decrease in SBP from being awake to asleep) are very common, each with a prevalence >30%, and both are associated with a 1.5 to 3-fold increased risk for cardiovascular disease (CVD) morbidity and mortality. Circadian and sleep-related factors are two of the most likely contributors to high asleep SBP and non-dipping BP. A better understanding of both circadian and sleep contributions, as well as the alignment between sleep behaviors and chronotype, to asleep BP levels and rhythms will allow for the development of interventions to lower asleep BP, restore BP dipping, and reduce BP-related CVD. The overall objective of the proposed study is to determine the associations of chronotype and sleep-related factors with mean BP, and BP dipping (Aim 1); the association of alignment between sleep timing and chronotype with mean BP, and BP dipping (Aim 2); and the association of circadian phase and amplitude with BP dipping under constant conditions (Aim 3). The proposed study, titled “Sleep and Circadian Contributions to Nighttime Blood Pressure (SCN-BP)” will achieve Aims 1 and 2 by collecting sleep and circadian data using questionnaires and wrist actigraphy as part of a large, diverse cohort of research participants at 3 sites (the University of Alabama at Birmingham [UAB], Columbia University Medical Center, and Kaiser Permanente Southern California). SCN-BP will then enroll participants who successfully complete Aims 1 and 2 at UAB to complete a 30-hour Constant Routine (CR) Protocol to determine circadian phase and amplitude, as well as BP levels under constant conditions. Findings from the proposed study will provide data that are critical to understand two of the most likely factors that contribute to high asleep BP and non-dipping BP, as well as generate preliminary data to examine the impact of non-sleep factors (e.g., feeding) on asleep BP levels and dipping. The proposed study is unique in that it will combine population science approaches in Aims 1 and 2 with basic/clinical science approaches in Aim 3 in a large, diverse sample sufficiently powered to examine differences by age, sex, race/ethnicity, and antihypertensive medication use. The proposed study will allow for the development of interventions to lower asleep BP, restore BP dipping, and reduce BP-related CVD.

项目摘要 高睡眠收缩压（SBP）和非浸血（BP）模式（a） 从醒着到睡眠的SBP降低<10％）很常见，每个人都患病率很高 > 30％，两者都与心血管疾病的风险增加1.5至3倍 （CVD）发病率和死亡率。昼夜节律和与睡眠有关的因素是最有可能的两个 高昂睡眠SBP和非浸入BP的贡献者。更好地理解两个昼夜节律 和睡眠的贡献，以及睡眠行为和表型之间的一致性 入睡的BP水平和节奏将允许开发干预措施，以降低入睡 BP，恢复BP浸入并减少与BP相关的CVD。 拟议研究的总体目的是确定表型和 平均BP和BP浸入的与睡眠有关的因素（AIM 1）；一致性协会 在睡眠时间和平均BP的时间型和表型之间，以及BP浸入（AIM 2）；和 在恒定条件下的昼夜节相和放大器与BP浸入的关联（AIM 3）。拟议的研究标题为“睡眠和昼夜节律对夜间血压的贡献 （SCN-BP）”将通过调查表收集睡眠和昼夜数据表实现目标1和2 和腕部行动学是3个地点的大型潜水员研究参与者的一部分（ 阿拉巴马大学伯明翰[UAB]，哥伦比亚大学医学中心和Kaiser 南加州的永久性）。然后，SCN-BP将招募成功的参与者 在UAB处完成目标1和2，以完成30小时的常规例程（CR）协议 在恒定条件下确定昼夜节相和放大器以及BP水平。 拟议研究的发现将提供有关了解其中两个至关重要的数据 最有可能导致高睡BP和非浸入bp的因素，以及生成 初步数据以检查非睡眠因素（例如，进食）对入睡BP水平的影响 和蘸酱。拟议的研究是独一无二的，它将结合种群科学 AIM 1和2中的方法在AIM 3中采用基本/临床科学方法3 样本足够动力，可以通过年龄，性别，种族/种族和种族来检查差异 使用降压药。拟议的研究将允许发展 降低入睡BP的干预措施，恢复BP浸入并减少与BP相关的CVD。