Sleep and Circadian Contributions to Nighttime Blood Pressure Rhythms (SCN-BP)

项目摘要 高睡眠收缩压（SBP）和非下降血压（BP）模式（a SBP从清醒到入睡下降<10%）非常常见，每种情况的患病率 > 30%，两者均与心血管疾病风险增加1.5至3倍相关 (CVD)发病率和死亡率。昼夜节律和睡眠相关的因素是最有可能的两个 高睡眠SBP和非下降BP的贡献者。更好地理解昼夜节律 睡眠贡献，以及睡眠行为和时钟类型之间的一致性， 睡眠血压水平和节律将允许开发干预措施以降低睡眠 BP，恢复BP下降，减少BP相关的CVD。 这项研究的总体目标是确定生理时钟型与 睡眠相关因素与平均血压和血压下降（目标1）;对齐的关联 睡眠时间与平均血压和血压下降（目标2）之间的关系; 在恒定条件下，昼夜节律相位和振幅与BP下降的关联（目的 3）。这项被提议的研究名为“睡眠和昼夜节律对夜间血压的影响 （SCN-BP）”将通过使用问卷收集睡眠和昼夜节律数据来实现目标1和2 和腕关节活动记录仪作为一个大型的，多样化的队列研究参与者在3个地点（ 位于伯明翰的亚拉巴马大学[UAB]、哥伦比亚大学医学中心和凯泽 Permanente Southern加州）。然后，SCN-BP将招募成功参加 在UAB完成目标1和2，以完成30小时恒定常规（CR）方案， 确定昼夜节律的相位和幅度，以及恒定条件下的BP水平。 拟议研究的结果将提供对理解两个关键问题至关重要的数据。 最有可能的因素，有助于高睡眠血压和非下降血压，以及产生 检查非睡眠因素的影响的初步数据（例如，进食）对睡眠BP水平的影响 和蘸酱。这项拟议中的研究是独一无二的，因为它将联合收割机人口科学 目标1和目标2中的方法与目标3中的基础/临床科学方法， 样本有足够的把握度来检查年龄、性别、种族/民族的差异， 抗高血压药物使用。拟议的研究将允许开发 降低睡眠血压、恢复血压下降和减少BP相关CVD的干预措施。

Project Summary High asleep systolic blood pressure (SBP) and a non-dipping blood pressure (BP) pattern (a <10% decrease in SBP from being awake to asleep) are very common, each with a prevalence >30%, and both are associated with a 1.5 to 3-fold increased risk for cardiovascular disease (CVD) morbidity and mortality. Circadian and sleep-related factors are two of the most likely contributors to high asleep SBP and non-dipping BP. A better understanding of both circadian and sleep contributions, as well as the alignment between sleep behaviors and chronotype, to asleep BP levels and rhythms will allow for the development of interventions to lower asleep BP, restore BP dipping, and reduce BP-related CVD. The overall objective of the proposed study is to determine the associations of chronotype and sleep-related factors with mean BP, and BP dipping (Aim 1); the association of alignment between sleep timing and chronotype with mean BP, and BP dipping (Aim 2); and the association of circadian phase and amplitude with BP dipping under constant conditions (Aim 3). The proposed study, titled “Sleep and Circadian Contributions to Nighttime Blood Pressure (SCN-BP)” will achieve Aims 1 and 2 by collecting sleep and circadian data using questionnaires and wrist actigraphy as part of a large, diverse cohort of research participants at 3 sites (the University of Alabama at Birmingham [UAB], Columbia University Medical Center, and Kaiser Permanente Southern California). SCN-BP will then enroll participants who successfully complete Aims 1 and 2 at UAB to complete a 30-hour Constant Routine (CR) Protocol to determine circadian phase and amplitude, as well as BP levels under constant conditions. Findings from the proposed study will provide data that are critical to understand two of the most likely factors that contribute to high asleep BP and non-dipping BP, as well as generate preliminary data to examine the impact of non-sleep factors (e.g., feeding) on asleep BP levels and dipping. The proposed study is unique in that it will combine population science approaches in Aims 1 and 2 with basic/clinical science approaches in Aim 3 in a large, diverse sample sufficiently powered to examine differences by age, sex, race/ethnicity, and antihypertensive medication use. The proposed study will allow for the development of interventions to lower asleep BP, restore BP dipping, and reduce BP-related CVD.