Identifying Differential Psychosocial and Neurobiological Risk Factors of the Transition from Acute to Chronic Pain in Black and Non-­Hispanic White Adults

识别黑人和非西班牙裔白人成人从急性疼痛转变为慢性疼痛的差异心理社会和神经生物学危险因素

• 批准号: 10576262
• 负责人: Bright Eze
• 金额: $ 4.39万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-25 至 2024-02-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10576262
• 关键词: Achievement; Activities of Daily Living; Acute; Address; Adult; Affect; Age; Area; Biological; Black American; Black Populations; Black race; Blood specimen; CREB1 gene; Chronic; Chronic low back pain; Clinical Research; Cohort Studies; DNA Methylation; DNA methylation profiling; Data; Disparity; Ethnic Origin; Event; Exclusion; Exposure to; Female; Foundations; Freezing; Future; Gene Expression; Gene Expression Profile; Genes; Genetic Transcription; Genomics; Goals; Health Sciences; High Prevalence; Incidence; Individual; Inflammation; Inflammation Mediators; Inflammatory; Interleukin-1; Interleukin-6; Intervention; Job Satisfaction; Knowledge; Laboratories; Life; Low Back Pain; Maintenance; Measures; Mentorship; Methods; Moods; Multiomic Data; Musculoskeletal; NF-kappa B; Neurobiology; Not Hispanic or Latino; Pain; Pain Research; Pain Threshold; Pain management; Participant; Pathway interactions; Persons; Phenotype; Physiological; Population; Postdoctoral Fellow; Process; Productivity; Public Health; Quality of life; RNA methylation; Race; Random Allocation; Rehabilitation therapy; Reporting; Research; Risk; Risk Factors; Role; Sampling; Sensory; Severities; Signal Pathway; Site; Socioeconomic Status; Statistical Data Interpretation; Stress; TNF gene; Techniques; Technology; Testing; Time; Traineeship; Training; Tube; United States; Whole Blood; Woman; Work; affective disturbance; age effect; biopsychosocial; black men; black women; career; chronic pain; design; differential expression; disability; ethnic minority population; follow-up; gene environment interaction; health disparity; improved; knowledge integration; low socioeconomic status; mRNA Expression; male; men; neurobiological mechanism; next generation; pain chronification; pain reduction; pain self-management; pain sensitivity; perceived discrimination; perceived stress; preservation; pressure; programs; psychosocial; racial minority population; response; secondary analysis; sex; skills; targeted treatment; theories

Abstract Low back pain affects an estimated 65 million individuals in the United States, and Black Americans are disproportionately affected by the detrimental consequences of pain, including a higher incidence of converting to chronic pain, reduced functional capacity, mood, and quality of life compared to Non-Hispanic whites (NHWs). Empirical evidence regarding the Conserved Transcriptional Response to Adversity (CTRA) suggests that adverse psychosocial conditions, such as perceived stress due to experienced discrimination or low socioeconomic status, cause increased expression of genes involved in inflammation and stress-related pathways. While these pathways theoretically overlap with those that influence the transition from acute to chronic pain, the CTRA has never been systematically examined in Black individuals who are at risk of a chronic pain trajectory. This F31 application was designed to provide the applicant with the knowledge and skills to establish a research trajectory in pain-related health disparities. He has garnered the support of a highly engaged and productive mentorship team to fulfill his traineeship goals and accomplish the study aims. The applicant’s overall goals are to: 1) gain a deep understanding of the methods and measures used in pain research; 2) build expertise in health disparities theory and measures; 3) acquire genomics knowledge and principles for carrying out rigorous laboratory techniques with next generation technologies; 4) perform the sequencing pipeline, statistical analysis and interpretation of multi-omic data; and, 5) advance and integrate knowledge of the psychosocial and neurobiological mechanisms of the transition from acute to chronic low back pain in Black Americans. The proposed study is a secondary analysis of a completed inception cohort study (R01NR013932; n=220) that tracked individuals at the onset of acute low back pain and followed them every six weeks for six months. The applicant will randomly select 40 Black and 40 NHW participants (20 men and 20 women each for a total of 80 participants) who developed chronic low back pain. Preserved whole blood samples that were drawn into PAXgene tubes and immediately frozen at -80oC will be processed (baseline acute low back pain and at 6-months/chronic low back pain) for RNA and DNA-methylation (DNAm) sequencing to assess gene x environment interactions. The study aims are to: 1) Identify differences in psychosocial (pain severity and interference, mood, perceived stress, work satisfaction) and neurobiological (quantitative sensory testing) factors; and, 2) Examine differential mRNA expression and DNAm profiles between Black and NHW participants with low back pain at acute onset and at 6-months follow-up. Race x sex comparisons will also be conducted. The proposed study will provide a first-step toward establishing the applicant’s program of research, and will identify unique factors that influence pain-related health disparities in Black individuals that may be used in the future to develop targeted therapy and ethnically and culturally- tailored pain self-management interventions.

摘要