VesiVax Vaccine Formulation Against Neisseria gonorrhoeae

针对淋病奈瑟氏菌的 VesiVax 疫苗配方

基本信息

批准号：
10576383
负责人：
Gary Fujii
金额：
$ 29.98万
依托单位：
MOLECULAR EXPRESS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-18 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10576383
关键词：
Adjuvant Agonist Agreement Animals Antibiotic Resistance Antibodies Antigen Targeting Antigens Binding Proteins Case/Control Studies Development Diagnosis Double-Stranded RNA Evaluation Formulation Goals Gonorrhea HIV Homologous Gene Hydrophobicity IgG1 Immune response Immunity Immunoglobulin A Immunoglobulin M Immunologics Individual Infection Interleukin-12 Knowledge Laboratories Ligands Link Lipid A Lipid Bilayers Lipids Liposomes Membrane Modeling Molecular Molecular Conformation Mus Nature Neisseria gonorrhoeae Neisseria meningitidis Peptides Phase Preparation Prevention Procedures Process Protein Engineering Proteins Public Health Recombinant Proteins Recombinants Reproductive Tract Infections Research Risk Serogroup B Neisseria meningitidis Services Sexually Transmitted Diseases Small Business Innovation Research Grant Surface System TLR4 gene Technology Testing United States Universities Vaccinated Vaccines Vesicle Virus Diseases Women&apos s Group amphiphilicity bactericide design dosage epidemiologic data flexibility gonorrhea vaccine immunogenicity lead candidate liposomal delivery liposomal formulation mouse model nanoparticulate novel phase 2 study professor protective effect public health relevance reproductive tract technology platform vaccine access vaccine efficacy vaccine formulation vaccine immunogenicity viral transmission

项目摘要

Project Summary The principal goal of this project is to develop a VesiVax®-based vaccine against Neisseria gonorrhoeae (Ng). The studies proposed in this SBIR Phase I application will be focused on co-formulating an newly identified surface-displayed outer membrane Ng protein, MtrE, with various immunostimulatory adjuvant molecules (IAMs) in the VesiVax® liposomal platform. We will characterize the immunogenicity of these VesiVax®-MtrE-IAM formulations in mice, and select for the best candidates to be further evaluated in a novel mouse upper reproductive tract Ng infection model. These studies will elucidate the immunological profile in a vaccine that will correlate with protective immunity against Ng.

项目摘要该项目的主要目的是开发针对Neiserseria的基于Vesivax®的疫苗 Gonorrhoeae（NG）。在此SBIR I期应用中提出的研究将集中于共同成型新鉴定的表面播种的外膜NG蛋白MTRE，具有各种免疫刺激性调节 Vesivax®脂质体平台中的分子（IAMS）。我们将表征这些免疫原性小鼠中的Vesivax®-MTRE-iam公式，并选择在小说中进一步评估的最佳候选者小鼠上部生殖道感染模型。这些研究将阐明A 疫苗将与NG的保护性免疫相关。