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Timing Of Exercise In Concussed Rat Athletes

脑震荡大鼠运动员的运动时机

基本信息

批准号：
10576291
负责人：
Mayumi Lynn Prins
金额：
$ 48.32万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10576291
关键词：
Address Adolescent Adolescent and Young Adult Adult Affect Age Animals Anxiety Behavioral Biogenesis Biological Markers Brain Brain Concussion Brain Injuries Brain-Derived Neurotrophic Factor Cerebrum Classification Development Equilibrium Exercise Experimental Models Exposure to Female Functional disorder Glucose Glutamates Goals Grant Guidelines Home Impaired cognition Injury Male Adolescents Mental Depression Metabolic Mitochondria Modeling Monitor N-acetylaspartate Physical activity Physiology Play Population Protocols documentation Psyche structure Rattus Recovery Reporting Research Rest Risk Rodent Role Running Severities Sex Differences Social Interaction Socialization Sports Standardization Study models Symptoms Synaptophysin Time Training Traumatic Brain Injury Work adolescent health allodynia brain health clinical translation clinically relevant cognitive testing experimental study glucose metabolism improved outcome insight male metabolic depression metabolic rate mild traumatic brain injury neurochemistry pain sensitivity prevent reduce symptoms response response to brain injury sedentary sex

项目摘要

Project Summary/Abstract Repeat concussions are a growing concern for adolescents and young adult athletes. Experimentally one of the problems is that no one has been addressing this in an “athlete” model. Growing evidence shows that the brains of those that exercise regularly (athletes) are very different than those that are sedentary. These differences will affect how the “athlete brain” responds to concussive injuries. In this application we have developed a rathlete model to study the effects of concussive injuries and recovery between the athlete brain and non-athlete brain in both male and female rats. This work will not only provide important information regarding brain injury research, but emphasize the role of exercise in adolescent health.

项目总结/摘要反复脑震荡是青少年和年轻成年运动员日益关注的问题。实验其中一个问题是，没有人以“运动员”模式来解决这个问题。越来越多的证据研究表明，那些经常锻炼的人（运动员）的大脑与那些经常锻炼的人（运动员）的大脑非常不同。久坐不动这些差异将影响“运动员大脑”对脑震荡损伤的反应。在这应用我们已经开发了一个rathlete模型来研究脑震荡损伤和恢复的影响运动员大脑和非运动员大脑之间的差异。这项工作不仅将提供有关脑损伤研究的重要信息，但强调运动在青少年健康