Cerebral Substrate Support After Traumatic Brain Injury

项目概要/摘要 基础科学和临床研究表明，创伤性脑损伤（TBI）会导致即刻和 葡萄糖摄取（CMRglc）短暂增加，以重建离子平衡和神经化学 失衡这是迅速其次是长期的葡萄糖代谢抑制，一个标志， 是脑代谢危机的重要组成部分。在这种抑郁症中，大脑 易受伤害，葡萄糖代谢有许多问题。我们已经证明，早期 在损伤后施用替代底物减少了细胞损失，改善了细胞能量， beahvioral结果。该补助金将直接比较替代基质的容量， 降低代谢危机，提高线粒体能量，减少自由基损伤，改善 在男性和女性受试者中的长期功能。这些研究的结果将确定 脑燃料对于创伤性脑损伤后的恢复是最佳的。

Project Summary/Abstract Basic science and clinical research has shown that traumatic brain injury (TBI) results in immediate and transient increases in glucose uptake (CMRglc) to re-establish ionic equilibrium and neurochemical imbalances. This is rapidly followed by a prolonged period of glucose metabolic depression, a hallmark of TBI and a critical component of the cerebral metabolic crisis. During this depression the brain is vulnerable and there are many problems with glucose metabolism. We have shown that early administration of alternative substrates after injury reduces cell loss, improves cellular energy and early beahvioral outcomes. This grant will directly compare the capacity of alternative substrates to decrease metabolic crisis, improve mitochondrial energy, decrease free radical damage and improve long-term function in both male and female subjects. Findings from these studies will establish which brain fuels are optimal for recovery in both genders after TBI.