Cerebral Substrate Support After Traumatic Brain Injury

脑外伤后的脑基质支持

• 批准号: 10447053
• 负责人: Mayumi Lynn Prins
• 金额: $ 34.13万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447053
• 关键词: Anaerobic Bacteria; Animals; Apoptosis; Basic Science; Behavioral; Biogenesis; Brain; Brain Injuries; Cells; Cerebrum; Clinical; Clinical Research; Cognitive; Cognitive deficits; Coupled; Craniocerebral Trauma; Development; Dose; Effectiveness; Equilibrium; Female; Free Radicals; Gender; Glucose; Glutamates; Goals; Grant; Histology; Human; Impairment; Injury; Ketones; Lesion; Mental Depression; Metabolic; Metabolic dysfunction; Metabolism; Mitochondria; Motor; Necrosis; Neurons; Outcome; Outcome Measure; Patients; Pentosephosphate Pathway; Physiological; Production; Property; Protons; Pyruvate; Rattus; Recovery; Recovery of Function; Reporting; Research; Research Personnel; Respiration; Sex Differences; Supplementation; Synaptic Transmission; Synaptic plasticity; TBI treatment; Therapeutic; Time; Traumatic Brain Injury; behavioral outcome; beta-Hydroxybutyrate; compare effectiveness; diagnostic tool; effectiveness evaluation; functional outcomes; glucose metabolism; glucose uptake; head-to-head comparison; improved; injury recovery; male; metabolic depression; mitochondrial dysfunction; neurochemistry; neuronal survival; neuroprotection; prevent; response; sex; treatment effect

Project Summary/Abstract Basic science and clinical research has shown that traumatic brain injury (TBI) results in immediate and transient increases in glucose uptake (CMRglc) to re-establish ionic equilibrium and neurochemical imbalances. This is rapidly followed by a prolonged period of glucose metabolic depression, a hallmark of TBI and a critical component of the cerebral metabolic crisis. During this depression the brain is vulnerable and there are many problems with glucose metabolism. We have shown that early administration of alternative substrates after injury reduces cell loss, improves cellular energy and early beahvioral outcomes. This grant will directly compare the capacity of alternative substrates to decrease metabolic crisis, improve mitochondrial energy, decrease free radical damage and improve long-term function in both male and female subjects. Findings from these studies will establish which brain fuels are optimal for recovery in both genders after TBI.

项目摘要/摘要 基础科学和临床研究表明，创伤性脑损伤(TBI)会导致即刻和 短暂的葡萄糖摄取增加(CMRglc)以重建离子平衡和神经化学 不平衡。这之后很快就会出现长时间的葡萄糖代谢抑制，这是一个标志 这是脑损伤的主要原因之一，也是脑代谢危机的重要组成部分。在这种抑郁期间，大脑 很脆弱，而且葡萄糖代谢有很多问题。我们很早就证明了 损伤后给予替代底物可减少细胞损失，改善细胞能量，并及早 行为的结果。这笔赠款将直接比较替代基质的容量与 减少代谢危机，提高线粒体能量，减少自由基损伤，改善 男性和女性受试者的长期功能。这些研究的结果将确定 脑燃料对脑外伤后的男女患者的康复都是最佳的。