Cerebral Substrate Support After Traumatic Brain Injury

项目摘要/摘要 基础科学和临床研究表明，创伤性脑损伤(TBI)会导致即刻和 短暂的葡萄糖摄取增加(CMRglc)以重建离子平衡和神经化学 不平衡。这之后很快就会出现长时间的葡萄糖代谢抑制，这是一个标志 这是脑损伤的主要原因之一，也是脑代谢危机的重要组成部分。在这种抑郁期间，大脑 很脆弱，而且葡萄糖代谢有很多问题。我们很早就证明了 损伤后给予替代底物可减少细胞损失，改善细胞能量，并及早 行为的结果。这笔赠款将直接比较替代基质的容量与 减少代谢危机，提高线粒体能量，减少自由基损伤，改善 男性和女性受试者的长期功能。这些研究的结果将确定 脑燃料对脑外伤后的男女患者的康复都是最佳的。

Project Summary/Abstract Basic science and clinical research has shown that traumatic brain injury (TBI) results in immediate and transient increases in glucose uptake (CMRglc) to re-establish ionic equilibrium and neurochemical imbalances. This is rapidly followed by a prolonged period of glucose metabolic depression, a hallmark of TBI and a critical component of the cerebral metabolic crisis. During this depression the brain is vulnerable and there are many problems with glucose metabolism. We have shown that early administration of alternative substrates after injury reduces cell loss, improves cellular energy and early beahvioral outcomes. This grant will directly compare the capacity of alternative substrates to decrease metabolic crisis, improve mitochondrial energy, decrease free radical damage and improve long-term function in both male and female subjects. Findings from these studies will establish which brain fuels are optimal for recovery in both genders after TBI.