Skeletal Muscle: Development, Regeneration and Disease

骨骼肌：发育、再生和疾病

• 批准号: 10237575
• 负责人: Elizabeth H Chen
• 金额: $ 2万
• 依托单位: SOCIETY FOR MUSCLE BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-06 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10237575
• 关键词: Address; Affect; Applications Grants; Area; Attention; Basic Science; Biology; Biomedical Engineering; Cell Therapy; Cells; Clinical; Collaborations; Communities; Country; Development; Disease; Disease model; Duchenne muscular dystrophy; Emerging Technologies; Ensure; Epigenetic Process; Extracellular Matrix; Facioscapulohumeral; Faculty; Fertilization; Fostering; Generations; Genetic; Genetic Transcription; Geography; Goals; Growth; Human; International; Italy; Lead; Malignant Neoplasms; Mentors; Minority; Modeling; Molecular and Cellular Biology; Muscle; Muscle Development; Muscle satellite cell; Muscular Dystrophies; Myoblasts; Myopathy; Natural regeneration; Policies; Postdoctoral Fellow; Regulation; Research; Research Personnel; Rhabdomyosarcoma; Science; Scientist; Series; Skeletal Muscle; Slide; Societies; Students; Therapeutic; Tissue Model; Tissues; Translating; Translational Research; Woman; Work; career development; career networking; diversity and inclusion; doctoral student; epigenetic regulation; experience; frontier; gene therapy; graduate student; human disease; induced pluripotent stem cell; malignant muscle neoplasm; meetings; metabolic abnormality assessment; molecular dynamics; muscle metabolism; muscle regeneration; myogenesis; novel; novel strategies; novel therapeutics; posters; professor; programs; repaired; symposium; therapy development; tissue repair; unpublished works

SUMMARY The goal of the “Skeletal muscle: development, regeneration and disease” conference is to bring together international leaders in skeletal muscle research to provide a forum for cutting edge genetic, cellular and molecular biology underlying muscle development, regeneration and disease. This Frontiers in Myogenesis series organized by the Society for Muscle Biology has been held every three years for the last twenty years and has successfully defined the state of the art in the field. The 2021 meeting will not only discuss recent discoveries in skeletal muscle development and repair, but will also encompass advances in our understanding of human diseases, including muscular dystrophies and cancer. Our keynote speaker will be Dr. Eric Olson, who has performed exceptional work in muscle development and developed therapeutic strategies for treating Duchenne muscular dystrophy. Eleven plenary sessions are planned to address the following topics: cellular and molecular dynamics of skeletal muscle development, myoblast fusion and muscle growth, muscle stem cell regulation, epigenetic regulation of skeletal muscle, iPS cells, bioengineering and emerging technologies to study and repair skeletal muscle, muscle metabolism and cancer, muscle tissue and disease models, microenvironment in skeletal muscle repair and disease, muscle disease mechanisms, and translating skeletal muscle science into new therapies. Invited speakers (36) have been selected for their scientific excellence, with particular attention to appropriate representation (42% women/minorities) and geographical diversity (39% are from non-US countries). In addition, 19 short talks will be selected from submitted abstracts to provide opportunities for postdocs and students to present their work. Speakers are explicitly required to talk about unpublished work, to ensure scientific discussions focused at the forefront of the field. In addition, we will have three poster sessions each accompanied by a “posters blitz” where poster presenters will give a 1-minute talk to highlight/advertise their work. To further foster interaction, we will organize lunch sessions so that speakers are evenly distributed and attendees can sign up to join their table. Finally, we have included two professional development sessions to discuss grant application, as well as diversity and inclusion in science. This Conference will provide a forum for discussing recent discoveries in skeletal muscle research, and foster cross-fertilization among investigators from diverse areas and backgrounds, to further advance our understanding of muscle biology and facilitate the development of translational efforts for potential therapies for muscle diseases.

摘要 “骨骼肌：发育、再生和疾病”会议的目标是将 骨骼肌研究的国际领先者为尖端遗传、细胞和 肌肉发育、再生和疾病的分子生物学基础。肌细胞发生的前沿 由肌肉生物学学会组织的系列赛在过去的二十年里每三年举办一次， 已经成功地定义了该领域的最先进水平。2021年的会议不仅将讨论最近的发现 在骨骼肌的发育和修复方面，但也将包括我们对人类理解的进步 疾病，包括肌肉营养不良和癌症。我们的主讲人将是埃里克·奥尔森博士，他有 在肌肉发育方面做了出色的工作，并开发了治疗杜兴的治疗策略 肌肉营养不良症。计划举行11次全体会议，讨论以下主题：细胞和分子 骨骼肌发育，成肌细胞融合和肌肉生长，肌肉干细胞调控， 骨骼肌、iPS细胞、生物工程和新兴研究与修复技术的表观遗传调控 骨骼肌，肌肉代谢和癌症，肌肉组织和疾病模型，微环境 骨骼肌修复和疾病，肌肉疾病机制，并将骨骼肌科学转化为 新疗法。被邀请的演讲者(36人)因他们在科学上的卓越表现而被挑选出来，并特别受到关注 适当的代表性(42%的妇女/少数族裔)和地域多样性(39%来自非美国 国家)。此外，将从提交的摘要中挑选19个简短的演讲，为以下方面提供机会 博士后和学生展示他们的作品。演讲者被明确要求谈论未发表的作品， 确保科学讨论集中在该领域的前沿。此外，我们将有三个海报会议 每一张海报都伴随着一场海报闪电战，海报主持人将发表一分钟的演讲来突出/宣传 他们的作品。为了进一步促进互动，我们将组织午餐会，以便发言者均匀分布 与会者可以注册加入他们的餐桌。最后，我们还包括了两个职业发展会议 讨论拨款申请，以及科学的多样性和包容性。本次会议将提供一个论坛 讨论骨骼肌研究的最新发现，并促进研究人员之间的交叉受精 来自不同领域和不同背景的人，进一步加深我们对肌肉生物学的了解，促进 为肌肉疾病的潜在治疗方法开发翻译努力。