Examining person and event level predictors of simultaneous alcohol and marijuana use via mixed methods

项目总结 这项F31研究和培训奖将使候选人能够发展成为一名公共卫生研究员，使用 先进的方法和统计技术，以审查个人和事件层面的物质决定因素 使用。酒精和大麻是年轻人最常用的两种物质，而且大多数 使用这两种物质的个人同时使用它们(在同一场合，因此它们的效果是重叠的)。 同时使用酒精和大麻(SAM)与单独使用酒精或大麻相比，与 更频繁和更强烈的饮酒，以及更多和更严重的与酒精相关的后果。 鉴于SAM使用的高流行率和不良影响，识别SAM使用的近端预测因素 在年轻人中传播艾滋病对于宣传预防和干预工作很重要。综合行为学 模型(IBM)通过强调重要的心理社会(态度、 规范)和语境(例如，社会语境)预测者。本F31中提出的研究的总体目标 是描述事件级SAM使用的特征，并研究IBM在大量饮酒中使用SAM的途径 年轻人，使用混合方法的方法。第一，定性方法(20-28个重量级的个人访谈 将被用来(A)阐明使用SAM的地形和近端前兆 在年轻成人酗酒者中进行调查，并(B)为生态瞬间的事件级评估决策提供信息 研究离散物质使用事件的评估(EMA)议定书。随后，此F31应用程序将 以NIAAA资助的R01 EMA研究(R01AA027495)为基础，检查高强度饮酒和酒精 在年轻人中诱发昏迷。候选人将向R01的S小组之一添加特定于萨姆的措施 评估和随后的30天均线爆裂。使用参与频繁SAM的前100名参与者 使用，候选人将分析SAM使用的人员和事件级别预测因素的直接影响，并检查 心理社会预测因子与SAM使用之间关系的事件级中介和调节因子 年轻的成年酗酒者。应聘者将与高技能的指导团队合作(Jennifer Merrill博士， Kristina Jackson和Kate Carey)在布朗大学的酒精和成瘾研究中心建立了四个 与本研究议程相关的专业领域：(1)年轻人使用SAM的内容领域知识； (2)定性方法和分析；(3)EMA方法；(4)EMA数据分析。本F31提案旨在 了解SAM使用的决定因素将有助于确定针对处于兴奋状态的年轻人的干预目标 物质滥用的风险和相关后果，并将使候选人做出重要的 对物质使用研究领域的贡献。

PROJECT SUMMARY This F31 research and training award will enable the candidate to develop as a public health researcher using advanced methodology and statistical techniques to examine person- and event-level determinants of substance use. Alcohol and marijuana are two of the most commonly used substances among young adults, and most individuals who use both substances use them simultaneously (in the same occasion so their effects overlap). Simultaneous alcohol and marijuana (SAM) use, compared to alcohol or marijuana use alone, is associated with more frequent and intense alcohol use, and a greater number and severity of alcohol-related consequences. Given the high prevalence and adverse effects of SAM use, identification of proximal predictors of SAM use among young adults is important for informing prevention and intervention efforts. The Integrated Behavioral Model (IBM) provides a framework for understanding SAM use by highlighting important psychosocial (attitudes, norms) and contextual (e.g., social context) predictors. The overall aims of the research proposed in this F31 are to characterize event-level SAM use and examine IBM-informed pathways of SAM use among heavy drinking young adults, using a mixed methods approach. First, qualitative methods (individual interviews with 20-28 heavy drinking young adult SAM users) will be used to (a) elucidate topography and proximal antecedents of SAM use among young adult heavy drinkers and (b) inform event-level assessment decisions for an ecological momentary assessment (EMA) protocol for studying discrete substance use events. Subsequently, this F31 application will build upon an NIAAA-funded R01 EMA study (R01AA027495) examining high intensity drinking and alcohol induced blackouts among young adults. The candidate will add SAM-specific measures to one of the R01’s panel assessments and subsequent 30 day EMA burst. Using the first 100 participants who engage in frequent SAM use, the candidate will analyze direct effects of person- and event-level predictors of SAM use, and examine event-level mediators and moderators of the association between psychosocial predictors and SAM use among young adult heavy drinkers. The candidate will work with a highly skilled mentorship team (Drs. Jennifer Merrill, Kristina Jackson, and Kate Carey) at Brown University’s Center for Alcohol and Addiction Studies to build four areas of expertise relevant to this research agenda: (1) content area knowledge of SAM use among young adults; (2) qualitative methods and analysis; (3) EMA methods; and (4) analysis of EMA data. This F31 proposal to understand determinants of SAM use will help to identify intervention targets for young adults who are at high risk for substance misuse and related consequences, and will position the candidate to make important contributions to the field of substance use research.