Participant Engagement and Cancer Genome Sequencing (PE-CGS): Coordinating Center

参与者参与和癌症基因组测序 (PE-CGS)：协调中心

• 批准号: 10237277
• 负责人: John F. Bridges
• 金额: $ 49.14万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-12 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10237277
• 关键词: Address; Advanced Malignant Neoplasm; Age of Onset; Cancer Biology; Cells; Clinical; Clinical Data; Clinical Sciences; Collaborations; Common Data Element; Communication; Community Outreach; Comprehensive Cancer Center; Controlled Vocabulary; DNA; DNA Sequence; DNA Sequence Alteration; Data; Data Collection; Databases; Development; Diagnostic Procedure; Dissemination and Implementation; Documentation; Ensure; FAIR principles; Faculty; Fostering; Future; Gene Expression; Genes; Genomics; Goals; Incidence; Knowledge; Malignant Neoplasms; Medicine; NCI Scholars Program; Office of Administrative Management; Ohio; Participant; Policies; Population; Positioning Attribute; Postdoctoral Fellow; Prevention strategy; Process; Public Relations; Research; Research Personnel; Research Support; Resources; Route; Scientist; Site Visit; Technology; The Cancer Genome Atlas; Time; Training; Translational Research; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Universities; Work; base; cancer cell; cancer genome; cancer genomics; cancer health disparity; cancer therapy; clinical center; collected works; college; community based participatory research; community engagement; data standards; data submission; epidemiologic data; ethnic minority population; experience; genome sequencing; genomic data; genomic profiles; health disparity; improved; innovation; insight; meetings; member; mortality; neoplastic cell; next generation sequencing; novel; outreach; patient engagement; preference; programs; racial minority; rare cancer; success; support network; web site; working group

Abstract Cancer genomics aims to improve our understanding and treatment of all cancers by identifying differences in DNA sequence and gene expression between tumor cells and normal host cells. Cancer genomics has contributed to many advances in treating several cancers, but the field is limited by a lack of genomics data. The Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network will promote and support research on direct participant engagement approaches to address these gaps, especially among rare cancers, highly lethal cancers, cancers with an early age of onset, cancers with high disparities in incidence/mortality, and cancers among under-represented minorities. Our team wishes to contribute to the important work of the (PE-CGS) Network by serving as its coordinating center. We have the necessary faculty, resources, and experience to address the needs and goals of the Network by supporting network coordination, promoting effective and equitable outreach and promotion, and establishing and disseminating network best practices. In addition to meeting all the requirements of the RFA, we bring innovation by establishing Participant Engagement Community (PEC) by applying the principles of community-based participatory research and by promoting a diverse pool of future scientists, especially those from underrepresented groups through a Summer Scholar Program and by two post-doctoral positions that will be supported by our comprehensive cancer center. Our proposal for the coordinating center is focused around four specific aims. First, we will effectively manage administrative and scientific coordination of the PE-CGS network. This will include providing administration/coordination, governing all advisory, organizing meetings/site visits, fostering collaboration, dissemination and implementation, and coordinating communication. Second, we will foster effective and culturally appropriate outreach and promotion activities. We will establish a common branded, public relations, communication resources, facilitating interactions, and managing outreach. Third, we will develop and disseminate network best practices and data collection/processing standards. We provide support for participant engagement and cancer genome sequencing activities, establish data standards, ensure data are accessible to the public, data are appropriately shared, and support efforts to make the Network sustainable. Finally, we want to address health disparities and promote equity throughout the Network and ensure there is a diverse pool of future scientists, including those from underrepresented groups, to support future efforts in participant engagement and cancer genomics. We envision that the network will need to evolve to address emerging issues in participant engagement and believe that being based in a university setting will provide us the capacity to anticipate and address these issues as they emerge. We are strongly supported by the OSU College of Medicine, the OSU Comprehensive Cancer Center, and the OSU Center for Clinical and Translational Science.

抽象的 癌症基因组学旨在通过确定所有癌症的理解和治疗。 肿瘤细胞和正常宿主细胞之间的DNA序列和基因表达。癌症基因组学具有 在治疗多种癌症方面有许多进展，但该领域受到缺乏基因组数据的限制。这 参与者参与和癌症基因组测序（PE-CGS）网络将促进和支持 有关直接参与者参与方法来解决这些差距的研究，尤其是在罕见的癌症中， 高度致命的癌症，发病年龄很小的癌症，发病率差异很高的癌症以及 代表性不足的少数群体中的癌症。 我们的团队希望通过将其作为其作为其重要工作的重要作用。 协调中心。我们有必要的教师，资源和经验来满足需求和 通过支持网络协调，促进有效且公平的外展和 促进，建立和传播网络最佳实践。除了满足所有要求 在RFA中，我们通过建立参与者参与社区（PEC）来实现创新 基于社区的参与性研究原则，并通过促进各种未来科学家的池 特别是那些通过夏季学者计划和两个博士后的人的代表性群体不足的小组 我们综合癌症中心将支持的职位。 我们对协调中心的建议集中在四个特定目标围绕。首先，我们将有效 管理PE-CGS网络的行政和科学协调。这将包括提供 管理/协调，管理所有咨询，组织会议/现场访问，促进协作， 传播和实施以及协调沟通。第二，我们将促进有效， 在文化上适当的外展和促进活动。我们将建立一个共同的品牌公共关系， 沟通资源，促进互动以及管理外展。第三，我们将发展和 传播网络最佳实践和数据收集/处理标准。我们为参与者提供支持 参与和癌症基因组测序活动，建立数据标准，确保数据可访问 公众，数据得到适当共享，并支持使网络可持续发展的努力。最后，我们想要 解决健康差异并促进整个网络的公平性，并确保有多种多样的池 未来的科学家，包括代表不足的群体的科学家，以支持参与者的未来努力 参与和癌症基因组学。我们设想网络将需要发展以解决新兴问题 在参与者的参与方面并相信，在大学环境中，将为我们提供能力 预期并解决这些问题时。我们得到OSU医学院的强烈支持， OSU综合癌症中心和OSU临床和转化科学中心。