权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Cystic Fibrosis Translational Research in the Post-CFTR Modulator Era

后 CFTR 调节器时代的囊性纤维化转化研究

基本信息

批准号：
10237338
负责人：
Bonnie W Ramsey
金额：
$ 121.48万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10237338
关键词：
Adult Affect Aging Area Basic Science Biological Biometry Child Chronic Clinical Clinical Research Collaborations Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Data Dentistry Development Direct Costs Disease Doctor of Philosophy Exocrine pancreas FDA approved Functional disorder Funding Future Genomics Genotype Germ-Free Goals Grant Growth Health Industry Inflammation Infrastructure Institution International Intestinal Diseases Islets of Langerhans Kidney Laboratories Leadership Link Lung Lung diseases Malignant neoplasm of gastrointestinal tract Measures Medicine Mentors Metabolic Methods Microbe Microbiology National Institute of Diabetes and Digestive and Kidney Diseases Nutritional Observational Study Outcome Measure Pathogenesis Patients Pediatrics Pharmaceutical Preparations Pharmacy facility Phenotype Physiological Physiology Population Process Public Health Recording of previous events Research Research Design Research Institute Research Personnel Resources Risk Science Scientist Specimen Statistical Methods Symptoms Training Translational Research Universities Vision Washington Work age group base care burden clinical effect clinical phenotype comparative cystic fibrosis mouse cystic fibrosis patients cystic fibrosis related diabetes design dissemination research drug development genome sciences gut microbiome improved infancy innovation insight interest kidney fibrosis medical schools member mid-career faculty next generation novel novel strategies novel therapeutic intervention novel therapeutics nutrition professor programs ranpirnase translational pipeline treatment effect

项目摘要

This P30 Cystic Fibrosis (CF) Research and Translational Core Center (CFRTC) is located at the University of Washington School of Medicine (UWSOM) and its affiliated institution, Seattle Children’s Research Institute (SCRI). This proposed P30 center program enhances an existing robust basic and clinical research base at these institutions totaling over $37 million direct costs in current research funding ($23.7 in DDK related funding representing 64% of total) and an additional $29 million in CF related infrastructure funding and includes 58 UW/SCRI and affiliate investigators in 19 departments and/or divisions across 4 Schools (Medicine: 51, Public Health: 3, Pharmacy: 2, Dentistry: 1). The UWSOM has a long history of excellence in CF-related translational research and microbiology with particular focus on gastrointestinal microbiome as well as CF related Diabetes (CFRD) in the past 5 years. The research for this P30 will focus on four Specific Aims: 1) Enhance the research cores and other infrastructure for CF research in NIDDK interest areas that promotes creative, interdisciplinary and clinically-impactful CF research. 2) Provide expertise to researchers world-wide to design innovative clinical studies that determine best practice and develop new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences. 3) Direct a successful pilot and feasibility grant program that attracts young and “new to CF” investigators, emphasizing support for investigators studying CF-related diabetes, GI disease, renal physiology, and other extra-pulmonary disease manifestations. 4) Train and mentor the next generation of laboratory, clinical, and biostatistical science leaders in CF locally and across the US. The center will be led by Co-PDs, Bonnie Ramsey, MD, Professor of Pediatrics and Pradeep Singh MD, Professor of Microbiology and Medicine, CF investigators both internationally recognized in their respective areas of clinical research and bacterial pathogenesis. They will be supported by other key leadership: Lucas Hoffman MD, PhD, Professor of Pediatrics and Microbiology, Charles Frevert, DVM, ScD, Professor of Department of Comparative Medicine, Christopher Goss MD, MPH, Professor of Medicine and Pediatrics, Stephen Salipante MD, PhD, Associate Professor of Laboratory Medicine, Colin Manoil PhD, Professor of Genome Sciences and David Nichols, Associate Professor of Pediatrics. The center will consist of an Administrative Core (Ramsey and Singh, Directors) and three biomedical cores, Host-Microbe (Hoffman and Frevert, Directors), Genomics (Salipante and Manoil, Directors) and Clinical Translational (Goss and Ramsey, Directors). The CFRTC will operate a Pilot and Feasibility (P&F) program led by Drs. Singh and Nichols. Three newly approved P&F projects are included in the current proposal chosen through a competitive process and approved by the Internal Advisory Board.

P30囊性纤维化（CF）研究与转化核心中心（CFRTC）位于美国国立卫生研究院