Program for Training in Cancer Epidemiology

7.项目摘要 我们建议更新NCI癌症流行病学培训计划。我们建议继续 每年支持12名受训人员，但已调整比例以满足NCI的建议， 建议三名博士前研究生和九名博士后研究员。我们利用那些 哈佛大学的学术环境陈公共卫生学院，与达纳- 法伯/哈佛癌症中心，网络医学的钱宁分部和众多附属 机构职能体系这些资源包括哈佛队列（护士健康研究I、II和III，健康 专业人员随访研究，医生健康研究，妇女健康研究，VITAL试验， 其他）。这些队列对所有癌症部位进行了数百万人年的重复随访， 超过十万人的血液和组织样本癌症研究的机会 在这个环境中几乎是无限的。我们汇集了优秀的教师导师 提供综合的跨学科经验和协作互动，一个专门的 核心课程与选修课程，非教学实践职业培训，个人 候选人培训计划和正在进行的计划评估。尖端的教学培训和 指导将培养新一代高技能和热情的研究人员， 影响癌症发病率和存活率的因素。一个主要的重点是利用众多的 现代组学方法，例如基因组学、代谢组学，连同生物样品阵列， 包括血液、口腔拭子和粪便的微生物组和肿瘤组织。多学科培训将 包括应用现代流行病学和生物统计学方法分析这些数据， 癌症研究的新方法。该培训计划目前是在今年42;我们不断 更新了程序，利用工作良好的方法，启动新的方面，并采取 利用新的机会，并相应地修改我们的导师组。一个不变的特点是， 我们从来不缺优秀的候选人。在持续的支持下，我们 我相信，这项培训计划将继续对进一步完成国家癌症研究所的使命产生重大影响， 通过预防和提高生存率减轻癌症负担。

7. Project Summary We propose to renew the NCI Cancer Epidemiology Training Program. We propose to continue to support 12 trainees per year, but have adjusted the proportions to meet NCI recommendations, and propose three pre-doctoral students and nine postdoctoral fellows. We leverage the enormously rich academic environment of the Harvard T.H. Chan School of Public Health, together with the Dana- Farber/Harvard Cancer Center, Channing Division of Network Medicine and a multitude of affiliated institutions. These resources include the Harvard cohorts (Nurses’ Health Studies I,II, and III, Health Professionals Follow-up Study, Physicians’ Health Study, Women’s Health Study, the VITAL trial,and others). These cohorts have millions of person-years of repeated follow-up for all cancer sites, as well as blood and tissue samples from over 100,000 individuals. The opportunities for cancer research within this environment are virtually limitless. We have brought together outstanding faculty mentors to provide integrated interdisciplinary experiences and collaborative interactions, a specialized curriculum with core and elective coursework, nondidactic practical career training, individual candidate training plans, and ongoing Program evaluation. Cutting-edge didactic training and mentoring will create a new generation of highly skilled and enthusiastic investigators to study factors that influence cancer incidence and survival. A major focus is to take advantage of the multitude of modern ‘omics methods, such as genomics, metabolomics, together with the array of biologic samples, including blood, oral swabs and stool for microbiome, and tumor tissue. The multidisciplinary training will include applying modern epidemiologic and biostatistical methods to analyze such data, and develop novel approaches for cancer research. This training program is currently in year 42; we have constantly updated the program, taking advantage of approaches that work well, initiating new aspects, and taking advantage of new opportunities, and revise our mentor group accordingly. One constant feature is that we have never had a shortage of outstanding candidates for the program. With continued support, we believe this training program will continue to have a major impact to further the mission of NCI to reduce the burden of cancer through prevention and improved survival.