Bridging the gap between brain network science and high-definition non-invasive brain stimulation to develop a scalable adult literacy intervention

弥合脑网络科学和高清非侵入性脑刺激之间的差距，开发可扩展的成人识字干预措施

• 批准号: 10253611
• 负责人: Katherine Aboud
• 金额: $ 36.7万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10253611
• 关键词: Address; Adult; Area; Award; Base of the Brain; Behavior; Behavior Therapy; Behavioral; Big Data; Brain; Brain imaging; Child; Clinical; Code; Communication; Complex; Coupling; Data Collection; Data Storage and Retrieval; Development; Disease; Economic Burden; Educational process of instructing; Elderly; Electroencephalography; Environment; Equipment; Faculty; Fellowship; Financial Support; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Opportunities; Goals; Growth; Image; Individual; Individual Differences; Infrastructure; Institution; Intervention; Knowledge; Language; Link; Low Prevalence; Magnetic Resonance Imaging; Mathematics; Measures; Memory; Mentors; Mentorship; Meta-Analysis; Methods; Neurosciences; Occupational Health; Outcome; Paper; Pattern; Positioning Attribute; Prevalence; Process; Protocols documentation; Psycholinguistics; Public Health; Publishing; Pythons; Randomized; Reader; Reading; Reading Disorder; Research; Running; Science; Secure; Special Education; Standardization; Structure; Supercomputing; Symptoms; System; Testing; Training; United States National Institutes of Health; Universities; Visit; Work; behavior test; behavioral outcome; brain pathway; brain research; career; clinically relevant; cognitive control; college; design; disability; economic outcome; functional magnetic resonance imaging/electroencephalography; health economics; innovation; literacy; magnetic resonance imaging/electroencephalography; meetings; multimodality; neuroimaging; new technology; noninvasive brain stimulation; novel; post intervention; pre-doctoral; prevent; programs; reading comprehension; relating to nervous system; resilience; response; statistics; stem; success; support network; symposium; theories; welfare

PROJECT SUMMARY Approximately 43 million adults in the U.S. struggle to comprehend basic texts. This is a major public health crisis given the strong association between reading comprehension (RC) ability and broad health and economic outcomes, including more than 300 billion annual economic burden related to low literacy in the US. Despite the prevalence of low RC, meta-analyses of behavioral interventions and national statistics in the US reveal no significant RC gains over the past 30 years. This is due in part to limitations of behavioral approaches to characterize the complex processes involved in RC. Brain research has identified more granular mechanisms of RC/RC ability. This includes my own research that has identified brain pathways that promote behavioral resilience in RC disorders, i.e. brain pathways that mitigate severe symptoms in RC disorders. However, brain research has thus far been unable to apply brain network science for a direct, clinical benefit. The goal of the current proposal is to address the need for brain-based RC interventions by integrating recent breakthroughs in two separate fields: brain network science of RC resilience and non-invasive brain network stimulation. I have established a line of research that uses functional MRI and EEG to characterize brain signatures of RC ability and resilience. I have found that cross-network communication between the reading- language brain network (RLN) and a brain network responsible for goal-oriented thought (the cognitive control network; CCN) is more predictive of RC outcomes than within-network communication (e.g. RLN alone). These results mirror findings in a range of disorders that connect the CCN to resilience and provide a compelling target for brain intervention. In a separate field, brain stimulation has also seen a recent breakthrough: using EEG-guided, individually-tuned stimulation of full networks results in recovered memory capacity in older adults that outlasts stimulation, but this has not been applied to other domains. The proposed project will take advantage of recent advances in RC brain network science and non-invasive brain stimulation to develop a safe, brain-based RC intervention protocol. I hypothesize that promotion of cross-network connectivity will result in increased RC ability particularly in low RC groups. In this project, I will determine: the causal effects of cross- vs within-network stimulation on readers' RC ability and brain metrics (Aim 1); how stimulation outcomes interact with individual differences in baseline RC ability/brain metrics (Aim 2); and the efficacy of stimulation beyond behavioral training effects (Aim 3). N = 225 adults with good and poor RC ability will be tested across 3 visits: a pre-intervention visit for baseline behavior and fMRI/EEG metrics; a stimulation visits (randomized/subject for cross- vs. within-network targets) with behavior and fMRI/EEG metrics, and a post-intervention visit to measure prolonged behavior and fMRI/EEG effects. Before stimulation, subjects will receive a short RC intervention. This approach will allow us to establish the efficacy of cutting-edge stimulation approaches in adult literacy, with potential applications in a range of other disorders.

项目摘要 美国约有4300万成年人努力理解基本文本。这是一个主要的公共卫生 危机鉴于阅读理解（RC）能力与广泛健康之间的牢固联系， 经济成果，包括与美国低识字率有关的3000亿年经济负担。 尽管RC低，但在美国的行为干预措施和国家统计数据的流行率很高 在过去的30年中没有明显的RC收益。这部分是由于行为的局限性 表征RC中涉及的复杂过程的方法。大脑研究已经确定了更细粒的 RC/RC能力的机制。这包括我自己的研究，该研究已经确定了促进的大脑途径 RC疾病中的行为弹性，即减轻RC疾病中严重症状的大脑途径。 但是，到目前为止，大脑研究无法将脑网络科学应用于直接的临床益处。 当前建议的目的是通过整合最近 两个单独领域的突破：RC弹性和无创脑网络的大脑网络科学 刺激。我已经建立了一系列研究，该研究使用功能性MRI和脑电图来表征大脑 RC能力和弹性的签名。我发现阅读之间的跨网络通信 - 语言大脑网络（RLN）和负责目标思想的大脑网络（认知控制 网络;与网络内部通信相比，CCN）更可预测RC结果（例如RLN）。 这些结果反映了各种疾病的发现，这些疾病将CCN连接到弹性并提供 令人信服的大脑干预目标。在另一个领域，大脑刺激也看到了最近的 突破：使用EEG引导的，单独调整的完整网络刺激导致回收记忆 老年人的能力超过了刺激，但这尚未应用于其他领域。提议 项目将利用RC脑网络科学和无创脑刺激的最新进展 制定安全的，基于大脑的RC干预方案。我假设促进跨网络 连通性将导致RC能力提高，尤其是在低RC组中。在这个项目中，我将确定： 交叉与网络内部刺激对读者RC能力和脑指标的因果影响（AIM 1）；如何 刺激结果与基线RC能力/脑指标的个体差异相互作用（AIM 2）；和 刺激的功效超出行为训练效果（AIM 3）。 n = 225名成年人的RC能力良好且不良 将在3次访问中进行测试：基线行为和fMRI/EEG指标的干预前访问；刺激 访问（随机/跨网络目标与网络内目标）具有行为和fMRI/EEG指标，A 干预后访问以测量长期行为和fMRI/EEG效应。刺激之前，受试者将 接受简短的RC干预。这种方法将使我们能够确定尖端刺激的功效 成人识字的方法，并在其他一系列疾病中使用了潜在的应用。