Bridging the gap between brain network science and high-definition non-invasive brain stimulation to develop a scalable adult literacy intervention

弥合脑网络科学和高清非侵入性脑刺激之间的差距，开发可扩展的成人识字干预措施

• 批准号: 10253611
• 负责人: Katherine Aboud
• 金额: $ 36.7万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10253611
• 关键词: Address; Adult; Area; Award; Base of the Brain; Behavior; Behavior Therapy; Behavioral; Big Data; Brain; Brain imaging; Child; Clinical; Code; Communication; Complex; Coupling; Data Collection; Data Storage and Retrieval; Development; Disease; Economic Burden; Educational process of instructing; Elderly; Electroencephalography; Environment; Equipment; Faculty; Fellowship; Financial Support; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Opportunities; Goals; Growth; Image; Individual; Individual Differences; Infrastructure; Institution; Intervention; Knowledge; Language; Link; Low Prevalence; Magnetic Resonance Imaging; Mathematics; Measures; Memory; Mentors; Mentorship; Meta-Analysis; Methods; Neurosciences; Occupational Health; Outcome; Paper; Pattern; Positioning Attribute; Prevalence; Process; Protocols documentation; Psycholinguistics; Public Health; Publishing; Pythons; Randomized; Reader; Reading; Reading Disorder; Research; Running; Science; Secure; Special Education; Standardization; Structure; Supercomputing; Symptoms; System; Testing; Training; United States National Institutes of Health; Universities; Visit; Work; behavior test; behavioral outcome; brain pathway; brain research; career; clinically relevant; cognitive control; college; design; disability; economic outcome; functional magnetic resonance imaging/electroencephalography; health economics; innovation; literacy; magnetic resonance imaging/electroencephalography; meetings; multimodality; neuroimaging; new technology; noninvasive brain stimulation; novel; post intervention; pre-doctoral; prevent; programs; reading comprehension; relating to nervous system; resilience; response; statistics; stem; success; support network; symposium; theories; welfare

PROJECT SUMMARY Approximately 43 million adults in the U.S. struggle to comprehend basic texts. This is a major public health crisis given the strong association between reading comprehension (RC) ability and broad health and economic outcomes, including more than 300 billion annual economic burden related to low literacy in the US. Despite the prevalence of low RC, meta-analyses of behavioral interventions and national statistics in the US reveal no significant RC gains over the past 30 years. This is due in part to limitations of behavioral approaches to characterize the complex processes involved in RC. Brain research has identified more granular mechanisms of RC/RC ability. This includes my own research that has identified brain pathways that promote behavioral resilience in RC disorders, i.e. brain pathways that mitigate severe symptoms in RC disorders. However, brain research has thus far been unable to apply brain network science for a direct, clinical benefit. The goal of the current proposal is to address the need for brain-based RC interventions by integrating recent breakthroughs in two separate fields: brain network science of RC resilience and non-invasive brain network stimulation. I have established a line of research that uses functional MRI and EEG to characterize brain signatures of RC ability and resilience. I have found that cross-network communication between the reading- language brain network (RLN) and a brain network responsible for goal-oriented thought (the cognitive control network; CCN) is more predictive of RC outcomes than within-network communication (e.g. RLN alone). These results mirror findings in a range of disorders that connect the CCN to resilience and provide a compelling target for brain intervention. In a separate field, brain stimulation has also seen a recent breakthrough: using EEG-guided, individually-tuned stimulation of full networks results in recovered memory capacity in older adults that outlasts stimulation, but this has not been applied to other domains. The proposed project will take advantage of recent advances in RC brain network science and non-invasive brain stimulation to develop a safe, brain-based RC intervention protocol. I hypothesize that promotion of cross-network connectivity will result in increased RC ability particularly in low RC groups. In this project, I will determine: the causal effects of cross- vs within-network stimulation on readers' RC ability and brain metrics (Aim 1); how stimulation outcomes interact with individual differences in baseline RC ability/brain metrics (Aim 2); and the efficacy of stimulation beyond behavioral training effects (Aim 3). N = 225 adults with good and poor RC ability will be tested across 3 visits: a pre-intervention visit for baseline behavior and fMRI/EEG metrics; a stimulation visits (randomized/subject for cross- vs. within-network targets) with behavior and fMRI/EEG metrics, and a post-intervention visit to measure prolonged behavior and fMRI/EEG effects. Before stimulation, subjects will receive a short RC intervention. This approach will allow us to establish the efficacy of cutting-edge stimulation approaches in adult literacy, with potential applications in a range of other disorders.

项目总结 在美国，大约有4300万成年人难以理解基本文本。这是一个重大的公共卫生问题 由于阅读理解能力(RC)与广泛的健康和 经济结果，包括美国与低识字率相关的每年3000多亿美元的经济负担。 尽管美国普遍存在低RC，但行为干预和国家统计的Meta分析 显示在过去30年中，RC没有显著的收益。这在一定程度上是由于行为上的限制 描述RC中所涉及的复杂过程的方法。大脑研究发现了更多颗粒状的 RC/RC能力的机制。这包括我自己的研究，它已经确定了促进 RC障碍中的行为弹性，即缓解RC障碍严重症状的大脑通路。 然而，到目前为止，大脑研究还无法将大脑网络科学应用于直接的临床益处。 当前提案的目标是通过整合最近的 在两个独立领域的突破：RC Resilience的脑网络科学和非侵入性脑网络 刺激。我已经建立了一系列的研究，使用功能核磁共振和脑电波来表征大脑 RC能力和韧性的签名。我发现，跨网络阅读之间的沟通- 语言脑网络(RLN)和负责目标导向思维的脑网络(认知控制 网络；CCN)比网络内通信(例如，仅RLN)更能预测RC结果。 这些结果反映了一系列疾病的发现，这些疾病将CCN与韧性联系起来，并提供了 大脑干预的引人注目的靶子。在另一个单独的领域，大脑刺激最近也看到了 突破：使用脑电引导的、单独调整的全网络刺激可恢复记忆 老年人的能力超过刺激，但这还没有应用于其他领域。建议数 该项目将利用RC脑网络科学和非侵入性脑刺激的最新进展 开发一种安全的、基于大脑的RC干预方案。我假设跨网络的推广 连接将导致RC能力增强，特别是在RC较低的组中。在这个项目中，我将确定： 网络间刺激与网络内刺激对读者RC能力和大脑指标的因果影响(目标1)；如何 刺激结果与基线RC能力/大脑指标(目标2)中的个体差异相互作用； 超越行为训练效果的刺激效果(目标3)。N=225名具有良好和较差RC能力的成年人 将在3次访问中进行测试：基线行为和fMRI/EEG指标的干预前访问；刺激 使用行为和fMRI/EEG指标的访问(针对跨网络目标和内部网络目标的随机/受试者)，以及 干预后访视以测量延长的行为和fMRI/EEG效应。在刺激之前，受试者会 接受一次简短的RC干预。这种方法将使我们能够确定尖端刺激的有效性 成人识字方法，潜在地应用于一系列其他障碍。