Preloading with Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts

对艾滋病毒呈阳性的吸烟者进行预负荷尼古丁替代疗法,以提高自我效能和戒烟尝试

基本信息

  • 批准号:
    10253389
  • 负责人:
  • 金额:
    $ 40.86万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-01 至 2024-10-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Cigarette smoking is more prevalent in persons with HIV (PWH) in the U.S. when compared with the general population and is linked to increased morbidity and mortality in this population. Furthermore, HIV-positive smokers have increased rates of lung and other smoking-related cancers. Smokers with HIV are a particularly challenging group, often reporting high severity of nicotine dependence and low rates of self-efficacy for quitting, both factors related to poor smoking cessation outcomes. Establishing more effective smoking cessation approaches for smokers with HIV, particularly those that address low self-efficacy and severe dependence, is a public health priority. The overall goal of this research project is to examine the feasibility, acceptability, and preliminary efficacy of nicotine replacement therapy preloading (NRT-P) in HIV-positive smokers, who are struggling with cigarette dependence, urge to smoke (craving) and low self-efficacy as barriers to successful smoking cessation. Sixty participants will be recruited into a 12-week randomized pilot study. Thirty participants (control condition) will receive standard smoking cessation counseling (NRT-S) and will initiate an 8-week course of combination nicotine patch and lozenge on quit date (week 4), consistent with recommended guideline based on smoking rate. Thirty participants (active condition) will start NRT patch 3 weeks prior to quit date, followed by an 8-week course of combination nicotine patch and lozenge, initiated on quit date. We will examine dependence, urge to smoke and self-efficacy for quitting prior to and following quit date. We will also examine differences in quit attempts and biochemically validated smoking abstinence between the control and active conditions at weeks 8 and 12. This study will be the first to examine the feasibility and initial efficacy of a novel intervention using NRT preloading to improve smoking cessation outcomes in PWH. Given the high prevalence of smoking and the significant morbidity associated with it in PWH, the development of effective strategies to reduce the risks related to smoking in this group is critical. If determined to be effective, this intervention could be readily disseminated in HIV clinics. Our study will provide key information on the potential benefit of NRT preloading in a population that is highly dependent on nicotine and highly vulnerable to smoking-related morbidity and mortality. The results from this project will provide the foundation for a future R01 application to the National Cancer Institute to conduct a full-scale randomized clinical trial.
抽象的 与一般人群相比,美国艾滋病毒感染者 (PWH) 吸烟更为普遍 人口,并与该人群发病率和死亡率的增加有关。此外,艾滋病毒呈阳性 吸烟者患肺癌和其他与吸烟有关的癌症的几率增加。携带艾滋病毒的吸烟者是一个特别 具有挑战性的群体,经常报告尼古丁依赖的严重程度和自我效能感低 戒烟,这两个因素都与戒烟结果不佳有关。建立更有效的吸烟方法 针对感染艾滋病毒的吸烟者的戒烟方法,特别是那些解决自我效能低下和严重吸烟问题的戒烟方法 依赖,是公共卫生的首要任务。该研究项目的总体目标是检验可行性, HIV 阳性患者预负荷尼古丁替代疗法 (NRT-P) 的可接受性和初步疗效 与香烟依赖作斗争的吸烟者,有吸烟的冲动(渴望)和低自我效能感 成功戒烟的障碍。将招募 60 名参与者参加为期 12 周的随机试点 学习。三十名参与者(对照条件)将接受标准戒烟咨询(NRT-S)和 将在戒烟日期(第 4 周)开始为期 8 周的尼古丁贴片和含片组合疗程,与 基于吸烟率的推荐指南。三十名参与者(活跃状态)将开始 NRT 补丁 3 戒烟日期前几周,随后进行为期 8 周的尼古丁贴片和含片组合疗程,从 戒烟日期。我们将检查戒烟前后的依赖性、吸烟冲动和戒烟自我效能 日期。我们还将研究戒烟尝试和生化验证的戒烟之间的差异 第 8 周和第 12 周时控制条件和活动条件之间的差异。这项研究将是第一个检验 使用 NRT 预负荷来改善的新型干预措施的可行性和初步疗效 PWH 的戒烟结果。鉴于吸烟的高流行率和显着的 艾滋病毒感染者中与之相关的发病率,制定有效的策略以减少与此相关的风险 吸烟对于这一群体来说至关重要。如果确定有效,这种干预措施很容易 在艾滋病毒诊所传播。我们的研究将提供有关潜在益处的关键信息 在高度依赖尼古丁且极易受到尼古丁影响的人群中进行 NRT 预加载 与吸烟相关的发病率和死亡率。该项目的结果将为 未来R01会向国家癌症研究所申请进行全面随机临床试验。

项目成果

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Patricia Ann Cioe其他文献

Patricia Ann Cioe的其他文献

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{{ truncateString('Patricia Ann Cioe', 18)}}的其他基金

A Peer Navigator Model to Improve Quit Attempts, Quitline Use, and Smoking Cessation Rates among HIV-positive smokers
用于改善艾滋病毒阳性吸烟者的戒烟尝试、戒烟热线使用和戒烟率的同伴导航模型
  • 批准号:
    10016255
  • 财政年份:
    2019
  • 资助金额:
    $ 40.86万
  • 项目类别:
Cardiovascular Risk Perception and Wellness Perspectives in HIV-infected Adults
HIV 感染者的心血管风险认知和健康观点
  • 批准号:
    8846418
  • 财政年份:
    2014
  • 资助金额:
    $ 40.86万
  • 项目类别:
Cardiovascular Knowledge, Risk Perception & Actual Risk in HIV-infected Patients
心血管知识、风险认知
  • 批准号:
    8150425
  • 财政年份:
    2010
  • 资助金额:
    $ 40.86万
  • 项目类别:
Cardiovascular Knowledge, Risk Perception & Actual Risk in HIV-infected Patients
心血管知识、风险认知
  • 批准号:
    8070984
  • 财政年份:
    2010
  • 资助金额:
    $ 40.86万
  • 项目类别:

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