To Reach Unrestricted Services for Transgender Women (TRUST)
为跨性别女性提供不受限制的服务 (TRUST)
基本信息
- 批准号:10252940
- 负责人:
- 金额:$ 24.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAIDS/HIV problemAcademic TrainingAccreditationAddressAdultAffectAfricanAlcoholsBackBehaviorCaribbean regionColorCommunitiesControl GroupsCountryDataData CollectionDevelopmentDrug abuseEpidemiologistEvidence based interventionFacultyFellowshipFloridaFocus GroupsFundingGenerationsGeographyGoalsGrantHIVHIV riskHIV/STDHealthHealth Care CostsIllicit DrugsImmigrantIncidenceIndividualInstitutionInternationalInterventionIntervention StudiesInterviewK-Series Research Career ProgramsKnowledgeLatin AmericaLatinaLatinoLeadLogistic RegressionsManualsMeasuresMentored Clinical Scientist Development Award (K08)MethodologyMethodsMinorityNational Institute of Drug AbuseOutcome MeasureParticipantPersonal SatisfactionPeruvianPhasePopulationPositioning AttributePostdoctoral FellowPreparationPrevalencePrimary PreventionProceduresProcessProphylactic treatmentPublic HealthPublicationsQualitative MethodsQualitative ResearchRandomizedResearchResearch ActivityResearch MethodologyResearch PersonnelRiskSamplingSecondary PreventionSecureServicesSexual and Gender MinoritiesSpecial PopulationStigmatizationStrategic PlanningStressSubstance Use DisorderSubstance abuse problemSurveysTarget PopulationsTestingTimeTrainingTraining ActivityTranslational ResearchTranslationsUnited StatesUnited States National Institutes of HealthUniversitiesVisitVisualVulnerable PopulationsWorkacceptability and feasibilityarmbasebrief interventioncareercareer developmentcomorbiditydata formatdesigneffective interventioneffective therapyefficacy evaluationefficacy testingethnic minority populationexperiencefollow-upgender minorityhealth disparityhigh riskhigh risk populationimprovedinnovationmarginalized populationmen who have sex with menmethod developmentpost interventionpre-exposure prophylaxispreventprimary outcomeracial and ethnicrandomized trialscreeningscreening, brief intervention, referral, and treatmentskillssocial determinantssocietal costsstemstress disorderstressorsubstance abuse brief interventionsubstance abuse preventionsubstance usetenure tracktherapy developmenttransgendertransgender mentransgender womentransmission processuptake
项目摘要
ABSTRACT/SUMMARY
Background: Transgender women are disproportionally affected by substance abuse and HIV. Evidence-based
interventions that can address both issues simultaneously may efficiently improve the overall health of transgender
women and reduce burdensome health and societal costs associated with substance abuse and HIV. In South Florida, the
majority of transgender women identify as Black or Latina, and can be grouped together as transgender women of color
(TWOC). TWOC are at highest risk for substance abuse and HIV acquisition, due to multiple external stressors arising as
a consequence of being a gender minority and a racial/ethnic minority. Studies have demonstrated Screening, Brief
Intervention, and Referral to Treatment (SBIRT) to be effective in mitigating development of substance use disorders
(SUDs) in other at-risk, marginalized populations. An adapted culturally-tailored SBIRT focused on linkage to substance
use services and HIV pre- and post-exposure prophylaxis (PrEP/nPEP) may effectively reduce the odds of individuals in
this special population developing a SUD and also facilitate their voluntary election of HIV screening and use of
PrEP/nPEP for HIV prevention. Objectives: K99 –In preparation for the independent phase, the career development phase
will include training in qualitative research methods and intervention development. R00 – In the independent phase, the
study objectives will be to (a) use a mixed-methods approach to obtain formative data among 40 transgender women that
will aid in adapting and developing an adapted culturally tailored SBIRT intervention (SBIRT-A), (b) pre-test and refine
SBIRT-A in 15 transgender women based on formative work and, (c) pilot test SBIRT-A in a sample of 76 transgender to
assess feasibility and acceptability. Pilot Design: Randomized trial among 76 adult (18 years or older) HIV uninfected
transgender women at moderate risk for developing a substance use disorder who will be randomized to either SBIRT-A
or the control condition (INFO-C). The INFO-C group will be a time-matched comparison control where information will
be provided on substance use and PrEP services in a non-SBIRT format via printed and audio-visual study material. There
will be a follow-up visit, three months after baseline, to assess linkage, and barriers and facilitators, to substance use
services and PrEP/nPEP. Analysis: Bivariate difference tests (chi square and t-tests) will be used to test differences
between SBIRT-A and INFO-C participants for the primary outcome measures (linkage to substance use services, PrEP,
and nPEP) at the 3-month visit. Multivariate binary logistic regressions (post- and pre-intervention) will be used to
determine substance use as a predictor of (1) HIV/STI screening in the past three months and (2 & 3) PrEP and nPEP
uptake in the past three months. Significance: Results derived from this study will help elucidate the relationship between
substance use and HIV among transgender women, including TWOC, in South Florida, and will provide evidence for a
larger study that can test the efficacy of SBIRT-A to reduce prevalence of substance abuse and HIV in this special
population. The aims of this study are parallel to the NIH/NIDA strategic plan to decrease HIV/AIDS health disparities,
prevent HIV transmission, and better understand the interaction of drug abuse and HIV/AIDS.
摘要/摘要
背景:跨性别女性不成比例地受到药物滥用和艾滋病毒的影响。循证的
能够同时解决这两个问题的干预措施可能有效地改善变性人的整体健康
并减少与药物滥用和艾滋病毒有关的沉重的健康和社会成本。在南佛罗里达州,
大多数变性人女性认为自己是黑人或拉丁裔,可以归类为有色人种变性人女性
(TWOC)。TWOC滥用药物和感染艾滋病毒的风险最高,原因是以下多种外部应激源
作为性别少数和种族/族裔少数的后果。研究已经证明了筛查,简短
干预和转诊治疗(SBIRT)在缓解物质使用障碍方面有效
(肥皂泡)在其他高危、边缘化人群中。适应文化的SBIRT侧重于与实质的联系
使用服务和艾滋病毒暴露前和暴露后预防(PrEP/nPEP)可能有效地降低个人在
这一特殊人群正在养成一种自愿性艾滋病,也方便了他们自愿选择进行艾滋病病毒的筛查和使用
预防艾滋病毒的准备/nPEP。目标:K99-为独立阶段、职业发展阶段做准备
将包括定性研究方法和干预发展方面的培训。R00-在独立阶段,
研究目标将是(A)使用混合方法在40名变性人妇女中获得形成数据,
将帮助适应和发展适应的文化定制SBIRT干预(SBIRT-A),(B)预试和改进
基于形成性工作的15名变性人女性的SBIRT-A,和(C)在76名变性人到
评估可行性和可接受性。试验设计:对76名未感染艾滋病毒的成年人(18岁或以上)进行随机试验
患有药物使用障碍的中等风险的变性人妇女将被随机分配到SBIRT-A
或控制条件(INFO-C)。INFO-C组将是一个时间匹配的比较对照,其中信息将
通过印刷和视听学习材料,以非SBIRT格式提供物质使用和PrEP服务。那里
将在基线后三个月进行后续访问,以评估与物质使用的联系、障碍和促进者
服务和PrEP/nPEP。分析:将使用双变量差异检验(卡方检验和t检验)来检验差异。
SBIRT-A和INFO-C参与者之间的主要结果衡量(与药物使用服务的联系,PrEP,
和nPEP)在3个月的访问中。将使用多变量二元Logistic回归(干预前后)来
确定药物使用情况作为(1)过去三个月的HIV/STI筛查和(2&3)PrEP和nPEP的预测因子
在过去的三个月里。意义:这项研究的结果将有助于阐明
在南佛罗里达州,包括TWOC在内的变性人女性中的药物使用和艾滋病毒之间的关系,并将为
一项更大规模的研究,可以测试SBIRT-A在降低药物滥用和艾滋病毒流行率方面的有效性
人口。这项研究的目的与NIH/NIDA减少艾滋病毒/艾滋病健康差距的战略计划是平行的,
预防艾滋病毒传播,更好地了解药物滥用和艾滋病毒/艾滋病的相互作用。
项目成果
期刊论文数量(0)
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Elena Cyrus其他文献
Elena Cyrus的其他文献
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{{ truncateString('Elena Cyrus', 18)}}的其他基金
ENTRUST - economic navigation and strengthening to realize unrestricted services for transgender women
ENTRUST - 经济导航和加强,为跨性别女性实现不受限制的服务
- 批准号:
10683578 - 财政年份:2023
- 资助金额:
$ 24.89万 - 项目类别:
To Reach Unrestricted Services for Transgender Women (TRUST)
为跨性别女性提供不受限制的服务 (TRUST)
- 批准号:
10461829 - 财政年份:2018
- 资助金额:
$ 24.89万 - 项目类别:
To Reach Unrestricted Services for Transgender Women (TRUST)
为跨性别女性提供不受限制的服务 (TRUST)
- 批准号:
10175277 - 财政年份:2018
- 资助金额:
$ 24.89万 - 项目类别: