Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study

ABCD 研究中青少年早期皮质发育轨迹与新兴维度精神病理学和相关危险因素的一致性

基本信息

项目摘要

Efforts to decipher biological signatures for mental illness now focus increasingly on adolescence, a period of rapid brain development that immediately precedes the peak age of onset for many disorders. Maturation of the cerebral cortex during this time has long been thought to mediate emergence of early symptoms. However, while specific cortical changes have been implicated in a small number of specific syndromes, for the most part, patterns in cortical development that underlie the differentiation of psychopathology remain uncertain. The ongoing Adolescent Brain Cognitive Development (ABCD) study provides an unprecedented opportunity to align emergence of specific patterns of psychopathology with specific changes in cortical maturation. Over the next 5 years, ABCD will obtain annual, standardized measures dimensional psychopathology, and biennial MRI scans, of 11,875 youths across 21 US-based sites, covering age 9 to 16. The proposed studies will leverage this longitudinal design to discover regionally- and temporally-specific features of cortical development that associate with emergence of dimensional psychopathology, and then to relate these patterns to specific profiles of underlying genomic and environmental risk. Analysis of baseline data from age 9-10, included in this application, indicates that psychopathology is in early stages of differentiation, although already strongly related to polygenic risk for child-onset disorders, and to well- established pre- and post-natal environmental insults. Aim 1 of the proposed studies will juxtapose clinical and imaging data from baseline through three follow-up time points, focusing primarily on whether departures from neurotypical age-related cortical thinning trajectories (assessed via intercept, slope, and quadratic indices) associate with emergence of specific dimensions of illness. The precise temporal alignment of clinical and cortical thinning trajectories will take an initial step towards inferring causal relationships, which will be further substantiated through triangulation with genomic (Aim 2) and environmental (Aim 3) risk profiles. Polygenic scoring methods developed by the Psychiatric Genomics Consortium will be used to determine whether cortical maturation trajectories developed in Aim 1 mediate relationships between genomic risk and emergent dimensional psychopathology. Then, using data from hundreds of environmental measures that canvass participants’ daily activities, nutrition, life stressors, socioeconomic status, family dynamics, neighborhood safety, and numerous other factors, we will use novel machine learning methods to develop profiles of exposomic risk factors that predict emergent dimensional psychopathology, and determine whether cortical maturation patterns mediate the relationship between environmental risk profiles and clinical course. By the conclusion of the proposed studies we hope to establish specific cortical signatures that bridge causal factors with emergent psychopathology in adolescence, and that can be leveraged to develop new preventative interventions.
破译精神疾病的生物学特征的努力现在越来越多地集中在青春期,一个时期

项目成果

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Joshua Lawrence Roffman其他文献

Joshua Lawrence Roffman的其他文献

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{{ truncateString('Joshua Lawrence Roffman', 18)}}的其他基金

Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study
ABCD 研究中青少年早期皮质发育轨迹与新兴维度精神病理学和相关危险因素的一致性
  • 批准号:
    10472710
  • 财政年份:
    2020
  • 资助金额:
    $ 42万
  • 项目类别:
Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study
ABCD 研究中青少年早期皮质发育轨迹与新兴维度精神病理学和相关危险因素的一致性
  • 批准号:
    10096054
  • 财政年份:
    2020
  • 资助金额:
    $ 42万
  • 项目类别:
Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study
ABCD 研究中青少年早期皮质发育轨迹与新兴维度精神病理学和相关危险因素的一致性
  • 批准号:
    10675032
  • 财政年份:
    2020
  • 资助金额:
    $ 42万
  • 项目类别:
MRI Studies of Folate-Related Genes, Diet, and Development: Promise for Psychosis
叶酸相关基因、饮食和发育的 MRI 研究:治疗精神病的希望
  • 批准号:
    8706977
  • 财政年份:
    2013
  • 资助金额:
    $ 42万
  • 项目类别:
MRI Studies of Folate-Related Genes, Diet, and Development: Promise for Psychosis
叶酸相关基因、饮食和发育的 MRI 研究:治疗精神病的希望
  • 批准号:
    8572813
  • 财政年份:
    2013
  • 资助金额:
    $ 42万
  • 项目类别:
MRI Studies of Folate-Related Genes, Diet, and Development: Promise for Psychosis
叶酸相关基因、饮食和发育的 MRI 研究:治疗精神病的希望
  • 批准号:
    8838674
  • 财政年份:
    2013
  • 资助金额:
    $ 42万
  • 项目类别:
MRI Studies of Folate-Related Genes, Diet, and Development: Promise for Psychosis
叶酸相关基因、饮食和发育的 MRI 研究:治疗精神病的希望
  • 批准号:
    9060404
  • 财政年份:
    2013
  • 资助金额:
    $ 42万
  • 项目类别:
Contributions of MTHFR Genotype to Frontal Lobe Dysfunction in Schizophrenia
MTHFR 基因型对精神分裂症额叶功能障碍的影响
  • 批准号:
    8416438
  • 财政年份:
    2009
  • 资助金额:
    $ 42万
  • 项目类别:
Contributions of MTHFR Genotype to Frontal Lobe Dysfunction in Schizophrenia
MTHFR 基因型对精神分裂症额叶功能障碍的影响
  • 批准号:
    7864199
  • 财政年份:
    2009
  • 资助金额:
    $ 42万
  • 项目类别:
Contributions of MTHFR Genotype to Frontal Lobe Dysfunction in Schizophrenia
MTHFR 基因型对精神分裂症额叶功能障碍的影响
  • 批准号:
    8247076
  • 财政年份:
    2009
  • 资助金额:
    $ 42万
  • 项目类别:

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