Beyond the Glomerulus: Kidney Tubule Dysfunction and Cognitive Impairments in the Elderly

肾小球之外：老年人的肾小管功能障碍和认知障碍

• 批准号: 10261422
• 负责人: Lindsay M. Miller
• 金额: $ 6.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261422
• 关键词: Acids; Address; Adult; Albumins; Albuminuria; Biological Markers; Biological Process; Blood Vessels; Body Composition; Brain; Brain Diseases; Cardiovascular Diseases; Cerebrospinal Fluid; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Kidney Failure; Clinical Markers; Cognition; Cognitive; Creatinine; Data; Dementia; Disease; Disease Outcome; Disease Progression; Elderly; Epidemiology; Etiology; Evaluation; Functional Magnetic Resonance Imaging; Functional disorder; Glomerular Filtration Rate; Goals; Health; Heart failure; Homeostasis; Hormones; Impaired cognition; Impairment; Injury; Intervention Trial; Kidney; Kidney Diseases; Kidney Failure; Kidney Glomerulus; Lead; Link; Magnetic Resonance Imaging; Measures; Mediating; Mentors; Mentorship; Microvascular Dysfunction; Nephrology; Nutrient; Participant; Pharmaceutical Preparations; Prevention strategy; Preventive; Process; Production; Renal function; Renal tubule structure; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Scientist; Statistical Methods; Stroke; Toxin; Training; Tubular formation; Work; aged; base; blood pressure intervention; brain health; brain volume; career development; cognitive function; community living; endothelial dysfunction; frailty; glomerular function; healthy aging; heart disease risk; imaging biomarker; insight; kidney dysfunction; mortality; novel; prognostic; renal tubular dysfunction; solute; therapeutic target; treatment strategy; urinary; white matter

PROJECT SUMMARY/ABSTRACT Chronic kidney disease and cognitive impairment are highly prevalent diseases in older adults and may share a common pathophysiology. Evaluations of the association between kidney disease and cognitive function have focused almost exclusively on glomerular function as the measure of kidney health. Kidney function is not limited to the glomerulus, and measures such as estimated glomerular filtration rate and albuminuria do not necessarily capture the health of the kidney tubules. Kidney tubules are important for acid/base homeostasis, nutrient reabsorption, toxin secretion, and hormone production, and are highly prognostic for kidney failure even in the presence of normal estimated glomerular filtration rate and albuminuria levels. In this proposal, I aim to characterize the relationship of kidney tubule dysfunction with cognitive decline, incident dementia and functional MRI measures of cerebrovascular disease, and evaluate whether these kidney tubule markers provide information independent of estimated glomerular filtration rate and albuminuria levels. Using the Systolic Blood Pressure Intervention Trial (SPRINT) data, I will evaluate the relationships between urinary markers of kidney tubule dysfunction with MRI measures of brain health, including white matter grade, cerebral blood flow, and total brain volume. Furthermore, I will provide novel data on the relationship of kidney tubule dysfunction with longitudinal changes in cognitive function and incident dementia among community-living older adults in the Healthy Aging and Body Composition Study. Through this proposal, I will determine the global relationship of kidney health (both glomerular and tubular) with cognitive health, including functional measures of cerebral vascular disease, cognitive decline and incident dementia. This research will also catalyze my career development as an emerging kidney and cognition scientist.

项目总结/文摘

项目成果

Relationship of Kidney Tubule Biomarkers with Cognition among Community-Living Elders in the Health ABC Study.

Health ABC 研究中肾小管生物标志物与社区老年人认知的关系。

• DOI: 10.34067/kid.0004022022
• 发表时间: 2022
• 期刊: Kidney360
• 作者: Miller,LindsayM;Sarnak,MarkJ;Rifkin,DenaE;Potok,OAlison;Fried,Linda;Kritchevsky,Steven;Drew,David;Shlipak,MichaelG;Ix,JoachimH
• 通讯作者: Ix,JoachimH