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Pharmacokinetic Physiologic Modeling in Simultaneous PET/MR

同步 PET/MR 中的药代动力学生理模型

基本信息

批准号：
10263163
负责人：
Marc David Normandin
金额：
$ 37.09万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10263163
关键词：
Acceleration Address Adoption Animals Area Beds Biological Biological Assay Cancer Detection Cardiac Cardiovascular Diseases Cardiovascular system Cell Nucleus Cell membrane Cicatrix Data Data Analyses Data Set Development Disease Dopamine Drug Kinetics Electron Spin Resonance Spectroscopy Environment Evaluation Extracellular Space Eye Family suidae Feedback Fostering Free Radicals Functional Magnetic Resonance Imaging Goals Image Imaging technology Institution Investigation Kinetics Laboratories Link Magnetic Resonance Imaging Maps Mathematics Measurement Measures Medicine Membrane Potentials Methodology Methods Mitochondria Modality Modeling Multimodal Imaging Muscle Cells Myocardium Neurotransmitters Oryctolagus cuniculus Outcome Oxidation-Reduction Oxidative Stress Oxides Patients Physiological Physiological Processes Physiology Positron-Emission Tomography Procedures Process Property Protocols documentation Published Comment Radiolabeled Receptor Activation Research Personnel Role Serotonin Services Signal Transduction Site System Techniques Technology Testing Tissues Tracer Translations Traumatic Brain Injury Validation Vendor Work animal data base body system cancer therapy clinical practice data acquisition data standards human subject image reconstruction imaging system improved in vivo individual patient innovation interest mitochondrial membrane model design molecular imaging neurotransmission neurotransmitter release nitroxyl nonhuman primate physiologic model porcine model pre-clinical preclinical study radioligand response targeted agent technology development tissue injury user-friendly

项目摘要

Project Summary PET and MRI offer complementary views of physiology and the ability to measure data from both modalities concurrently provides a unique opportunity to study biological mechanisms in ways that were heretofore impossible to realize in intact animals, including human subjects. However, this advance in hardware and data acquisition poses new challenges for data analysis and interpretation due to the fact that the modalities are based upon different physical principles and generally reflect different in vivo phenomena. Conceptually, we address the problem and seize the opportunity via integrated PET/MR analysis frameworks wherein shared physiological mechanisms mathematically link quantitative PET and MR models, improving the accuracy and precision of physiological measurements and, in several instances, permitting outcomes not achievable using either modality alone. This general approach is proposed for development in several specific and illustrative cases – neurotransmission, mitochondrial membrane potential, and oxidative stress – that together span diverse organ systems, physiological processes, and potential disease applications.

项目总结