Metabolic Stress Signaling

代谢应激信号

基本信息

  • 批准号:
    10263263
  • 负责人:
  • 金额:
    $ 52.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-04-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Human obesity represents a serious world-wide health problem. One consequence of obesity is the development of metabolic syndrome, characterized by insulin resistance and hyperglycemia, that can lead to b-cell dysfunction and type 2 diabetes. It is therefore important that we gain an understanding of the physiology and pathophysiology of the development of obesity because this knowledge represents a basis for the design of potential therapeutic interventions. Recent studies have identified the cJun NH2-terminal kinase (JNK) signal transduction pathway as a mediator of metabolic stress responses. Feeding a high fat diet (HFD) causes increased JNK activity and promotes both obesity and insulin resistance. Studies using tissue-specific knockout mice demonstrate a central role for JNK in the regulation of energy expenditure and the development of obesity. In contrast, JNK in peripheral tissues can cause insulin resistance without changes in obesity. The mechanism that accounts for JNK-dependent insulin resistance caused by feeding a HFD has not been defined. This research program is focused on the metabolic function of hepatic JNK signaling. During the initial period of research support, we identified the PPARa pathway as a major target of hepatic JNK signaling that contributes to HFD-induced insulin resistance. We demonstrated that JNK activation caused by feeding a HFD potently suppresses PPARa activity. A key target of PPARa -mediated hepatic gene expression is the hepatokine fibroblast growth factor 21 (FGF21). Consequently, disruption of JNK signaling in the liver causes increased hepatic PPARa activity, increased amounts of FGF21 circulating in the blood, and improved glycemia in HFD-fed mice. Disruption of hepatic Fgf21 expression prevents the effects of JNK deficiency to cause improved glycemia. The PPARa/FGF21 axis therefore represents a major target of hepatic JNK signaling that promotes systemic insulin sensitivity. The overall goal of this research program is to identify mechanisms of hepatic JNK signaling that contribute to the regulation of insulin sensitivity. Our analysis establishes a key role for hepatic PPARa. However, the molecular target(s) that mediate the effects of JNK on PPARa have not been established. The identification of molecular mechanism is the focus of this renewal application. Achievement of the goals of this proposal will increase understanding of the molecular response to obesity. We anticipate that the successful completion of this research program will lead to the identification of new mechanisms that contribute to the obesity response. This knowledge may represent a basis for the design of novel therapeutic strategies for the treatment of metabolic syndrome and type 2 diabetes.
人类肥胖是一个严重的全球性健康问题。肥胖的一个后果是

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)

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Roger J Davis其他文献

Keep the 'phospho' on MAPK, be happy
让 MAPK 上保留“磷酸”,开心点。
  • DOI:
    10.1038/nm1110-1187
  • 发表时间:
    2010-11-04
  • 期刊:
  • 影响因子:
    50.000
  • 作者:
    Schahram Akbarian;Roger J Davis
  • 通讯作者:
    Roger J Davis
Signaling and Cell Cycle Regulation During Liver Development in the Rat• 269
大鼠肝脏发育过程中的信号传导和细胞周期调控•269
  • DOI:
    10.1203/00006450-199804001-00290
  • 发表时间:
    1998-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Philip A Gruppuso;Michael Awad;Joan M Boylan;Herve Enslen;Roger J Davis
  • 通讯作者:
    Roger J Davis

Roger J Davis的其他文献

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{{ truncateString('Roger J Davis', 18)}}的其他基金

Promotion of fatty liver disease by the ASK1 pathway
ASK1 通路促进脂肪肝疾病
  • 批准号:
    10224186
  • 财政年份:
    2019
  • 资助金额:
    $ 52.78万
  • 项目类别:
Promotion of fatty liver disease by the ASK1 pathway
ASK1 通路促进脂肪肝疾病
  • 批准号:
    10021651
  • 财政年份:
    2019
  • 资助金额:
    $ 52.78万
  • 项目类别:
Adipose Tissue Metabolic Stress Responses
脂肪组织代谢应激反应
  • 批准号:
    9401372
  • 财政年份:
    2017
  • 资助金额:
    $ 52.78万
  • 项目类别:
Adipose Tissue Metabolic Stress Responses
脂肪组织代谢应激反应
  • 批准号:
    10651878
  • 财政年份:
    2017
  • 资助金额:
    $ 52.78万
  • 项目类别:
Adipose Tissue Metabolic Stress Responses
脂肪组织代谢应激反应
  • 批准号:
    10516801
  • 财政年份:
    2017
  • 资助金额:
    $ 52.78万
  • 项目类别:
Metabolic stress signaling
代谢应激信号
  • 批准号:
    9128103
  • 财政年份:
    2016
  • 资助金额:
    $ 52.78万
  • 项目类别:
Metabolic Stress Signaling
代谢应激信号
  • 批准号:
    10656434
  • 财政年份:
    2016
  • 资助金额:
    $ 52.78万
  • 项目类别:
Metabolic Stress Signaling
代谢应激信号
  • 批准号:
    10119846
  • 财政年份:
    2016
  • 资助金额:
    $ 52.78万
  • 项目类别:
Metabolic Stress Signaling
代谢应激信号
  • 批准号:
    10437020
  • 财政年份:
    2016
  • 资助金额:
    $ 52.78万
  • 项目类别:
Systems Biology of Insulin Resistance
胰岛素抵抗的系统生物学
  • 批准号:
    8053081
  • 财政年份:
    2011
  • 资助金额:
    $ 52.78万
  • 项目类别:

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