Neuroimaging Core

神经影像核心

• 批准号: 10263714
• 负责人: Mark J Lowe
• 金额: $ 40.97万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263714
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Amyloid; Blood - brain barrier anatomy; Brain; Cerebrovascular Circulation; Clinic; Clinical; Clinical Trials; Communities; Data; Data Analyses; Data Storage and Retrieval; Dementia; Diagnostic Imaging; Discipline of Nuclear Medicine; Disease Progression; Environment; Evolution; Fingerprint; Functional disorder; Generations; Goals; Histopathology; Human Resources; Image; Image Enhancement; Imaging Techniques; Individual; Infrastructure; Investigation; Laboratory Research; Magnetic Resonance Imaging; Measures; Mentors; Methods; Monitor; Ohio; Participant; Population; Positron-Emission Tomography; Research; Research Personnel; Resolution; Resources; Risk; Software Tools; Specific qualifier value; Techniques; Tissues; Training; Training Support; Training and Education; Universities; biomarker development; career; contrast enhanced; data acquisition; data curation; data dissemination; data exchange; data management; education research; education resources; experience; image reconstruction; interest; multimodality; neuroimaging; neuropathology; outreach; patient population; prospective; protocol development; quality assurance; recruit; response; statistics; tool; ultra high resolution; vascular injury

Project Summary The overall goal of the Neuroimaging Core (NIC) is to enhance the Cleveland Alzheimer's Disease Research Center (CADRC) through the application of prospectively acquired advanced imaging and to provide high level imaging data analysis support and infrastructure to CADRC cores and Alzheimer's disease and related dementia (AD/ADRD) researchers both regionally, nationally, and through the National Alzheimer's Coordinating Center (NACC). Specifically, the NIC will prospectively acquire high quality MRI and PET data in CADRC participants, as well as better than 0.2mm isotropic spatial resolution ultra-high field MRI in ex-vivo brains of donors to the CADRC. The NIC will provide neuroimaging expertise to investigators in the CADRC and the general AD/ADRD. There are five aims of the NIC, 1) In addition to acquiring ADNI-compatible MRI data, to collect high quality multi-modal MRI data that will permit studies of quantitative T1, T2, cerebral blood flow, tissue microstructure, and blood brain barrier integrity, 2) to establish methods to permit acquisition of harmonized amyloid PET images across multiple centers using latest generation scanners and techniques, 3) acquire ultrahigh spatial resolution 7 tesla MRI images in ex-vivo brains of donors, and provide for comparison to subsequent histopathology, 4) perform detailed quality assurance and curation of data for dissemination to the NACC and broadly to the AD/ADRD research community, and 5) to train and mentor new and early career investigators in advanced imaging analysis techniques. The NIC builds on the strengths of the imaging environment in Northeast Ohio to enhance the imaging resources and data available to the AD/ADRD research community.

项目摘要 神经影像学核心（NIC）的总体目标是加强克利夫兰阿尔茨海默病研究 中心（CADRC）通过应用前瞻性采集的先进成像，并提供高水平的 成像数据分析支持和基础设施，以CADRC核心和阿尔茨海默病及相关 老年痴呆症（AD/ADRD）研究人员在区域，国家和通过国家阿尔茨海默氏症 协调中心。具体而言，NIC将前瞻性地采集高质量的MRI和PET数据， CADRC参与者，以及优于0.2mm的各向同性空间分辨率超高场MRI离体 捐赠者的大脑NIC将为CADRC的研究者提供神经影像学专业知识 和一般AD/ADRD。NIC有五个目标，1）除了获得ADNI兼容的MRI外， 数据，以收集高质量的多模态MRI数据，这将允许研究定量T1，T2，脑血 流动、组织微结构和血脑屏障完整性，2）建立允许获得 使用最新一代扫描仪和技术协调多个中心的淀粉样蛋白PET图像，3） 在供体的离体脑中获得空间分辨率为7特斯拉的MRI图像，并提供比较 4）进行详细的质量保证和数据管理，以便传播到 NACC和广泛的AD/ADRD研究社区，以及5）培训和指导新的和早期的职业生涯 先进的成像分析技术。NIC建立在映像的优势之上 环境在东北俄亥俄州，以提高成像资源和数据可用于AD/ADRD研究 社区