Survey and Biospecimen Shared Resource

核心011 -调查和生物样本共享资源 项目总结/摘要 调查和生物标本共享资源（SBSR）的使命是提供高质量的调查和 实验室服务，以支持范德比尔特-英格拉姆癌症中心（VICC）的研究社区，包括我们的 田纳西州立大学梅哈里医学院和其他NCI癌症中心的VICC成员和合作伙伴 中心.这一使命通过两项不同但互补的职能来完成：调查研究服务和 实验室服务。调查服务包括研究设计或实施咨询，调查 编程，参与者登记，计算机辅助电话访谈，医疗记录审查和 学习邮件。实验室服务包括研究设计咨询、生物标本采集、 处理、储存和检索、DNA/RNA提取、基因分型和生物标志物测定。SBSR还 管理多项研究的生物储存库，包括三项大型前瞻性队列研究和几项 大型病例对照研究。SBSR的科学联合主任指导了涉及数据和 从美国和国外的20多万名研究参与者中收集生物样本。因此 SBSR为VICC成员提供获得大规模人口方面的重要专业知识和能力的机会- 基础研究;避免了与雇用和培训数据收集和抽样工作人员有关的启动成本 处理;共享经验丰富的研究人员，以降低研究成本;实施严格的质量控制 协议;并实现高质量的标本和数据收集和处理。重大科学 SBSR的成就反映在服务使用和出版物中。SBSR支持多个 正在招募参与者、收集调查数据和/或生物标本或进行生物学研究的研究 对收集的样品进行分析。国际中心的26个成员已从该资源的服务中受益， 改进研究设计和研究质量。获得同行审查支持的维也纳国际中心成员占91%， 实验室服务和调查服务分别占总服务使用量的98%。这种共享资源 支持自2015年以来发表的200多篇癌症相关手稿的出版，包括期刊 例如JAMA、Nature、Nature Genetics、JNCI和Cancer Research。通过实施和分享 SBSR工作人员向用户展示了严格的行为方法的有效性， 人口为基础的研究，这使得个人调查员，学生，研究员和工作人员更好地 将这些做法纳入他们的研究计划。因此，SBSR服务对于研究至关重要 由VICC成员在多个VICC研究计划中进行。

CORE 011 – SURVEY AND BIOSPECIMEN SHARED RESOUCE PROJECT SUMMARY/ABSTRACT The mission of the Survey and Biospecimen Shared Resource (SBSR) is to provide high-quality survey and laboratory services to support the Vanderbilt-Ingram Cancer Center (VICC) research community, inclusive of our VICC members and partners at Meharry Medical College, Tennessee State University, and other NCI Cancer Centers. This mission is fulfilled through two distinct but complementary functions: survey research services and laboratory services. The survey services include consultation for study design or implementation, survey programming, participant enrollment, computer-assisted telephone interviewing, medical record review and study mailings. The laboratory services include consultation for study design, biospecimen collection, processing, storage and retrieval, DNA/RNA extraction, genotyping, and biomarker assays. The SBSR also manages biorepositories for multiple studies including from three large prospective cohort studies and several large case-control studies. The scientific co-Directors of the SBSR have directed studies involving data and biologic sample collection from more than 200,000 study participants in the United States and abroad. Thus, the SBSR provides VICC members with access to significant expertise and capabilities in large-scale population- based research; avoids the start-up costs associated with hiring and training staff for data collection and sample processing; shares experienced research staff to reduce study costs; implements rigorous quality control protocols; and enables high quality specimen and data collection and processing. The major scientific achievement of the SBSR is reflected in the service utilization and publications. The SBSR supports multiple studies that are recruiting participants, collecting survey data and/or biospecimens, or performing biological assays on collected samples. Twenty-six VICC members have benefited from the services of the resource to improve study design and research quality. VICC members with peer-reviewed support account for 91% and 98% of total service usage for the laboratory services and survey services, respectively. This shared resource has supported the publication of over 200 cancer-related manuscripts published since 2015 including in journals such as JAMA, Nature, Nature Genetics, JNCI and Cancer Research. Through the implementation and sharing of best practices, the SBSR staff demonstrates to users the effectiveness of a rigorous approach to the conduct of population-based research, which enables individual investigators, students, fellows and staff to better incorporate these practices into their research programs. Thus, the SBSR services are critical for the research conducted by VICC members across multiple VICC research programs.