"Role of the cytotoxin, CptA, from the emerging bacterial pathogen Sneathia vaginalis, in pathogenesis"

“来自新兴细菌病原体阴道球菌的细胞毒素 CptA 在发病机制中的作用”

基本信息

项目摘要

PROJECT SUMMARY: Sneathia vaginalis (Sv) is emerging as a pathogen that is significantly associated with preterm birth and can cause numerous infections including amnionitis, osteoarthritis, meningitis, bacteremia, and urethritis. Due to its fastidious nature, it has only recently been recognized as a pathogen through the use of DNA-based methods. Because it has been under-recognized as a pathogen, the biology and the pathogenesis of S. vaginalis remain almost entirely uncharacterized. We have identified a hemolytic and cytopathogenic toxin produced by S. vaginalis that we have named CptA. Antiserum against CptA abrogates traversal of Sv across intact human fetal membranes suggesting that the toxin plays a role in pathogenesis. This project has three main goals. The first is to assess the maternal and fetal antibody response to CptA during natural colonization/infection. The second is to establish the role of CptA in traversal of and damage to fetal membranes by Sv. The third is to determine whether the association between Sv and preterm birth is causal by developing a mouse model of Sv infection during pregnancy. pathogenesis Characterization of this novel pore-forming toxin will break ground in our understanding of this emerging pathogen.
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项目成果

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KIMBERLY Kay JEFFERSON其他文献

KIMBERLY Kay JEFFERSON的其他文献

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{{ truncateString('KIMBERLY Kay JEFFERSON', 18)}}的其他基金

The Virulome of Infectious Preterm Birth (Project 2; PI: Jefferson)
传染性早产的病毒组(项目 2;负责人:Jefferson)
  • 批准号:
    8655803
  • 财政年份:
    2014
  • 资助金额:
    $ 23.29万
  • 项目类别:
The Virulome of Infectious Preterm Birth (Project 2; PI: Jefferson)
传染性早产的病毒组(项目 2;负责人:Jefferson)
  • 批准号:
    8354916
  • 财政年份:
    2012
  • 资助金额:
    $ 23.29万
  • 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
  • 批准号:
    8147498
  • 财政年份:
    2010
  • 资助金额:
    $ 23.29万
  • 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
  • 批准号:
    7391713
  • 财政年份:
    2007
  • 资助金额:
    $ 23.29万
  • 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
  • 批准号:
    7796865
  • 财政年份:
    2007
  • 资助金额:
    $ 23.29万
  • 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
  • 批准号:
    7599211
  • 财政年份:
    2007
  • 资助金额:
    $ 23.29万
  • 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
  • 批准号:
    7210257
  • 财政年份:
    2007
  • 资助金额:
    $ 23.29万
  • 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
  • 批准号:
    8038279
  • 财政年份:
    2007
  • 资助金额:
    $ 23.29万
  • 项目类别:
Gene expression in S aureus biofilms
金黄色葡萄球菌生物膜中的基因表达
  • 批准号:
    7227426
  • 财政年份:
    2006
  • 资助金额:
    $ 23.29万
  • 项目类别:
Gene expression in S aureus biofilms
金黄色葡萄球菌生物膜中的基因表达
  • 批准号:
    6851133
  • 财政年份:
    2006
  • 资助金额:
    $ 23.29万
  • 项目类别:

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