"Role of the cytotoxin, CptA, from the emerging bacterial pathogen Sneathia vaginalis, in pathogenesis"
“来自新兴细菌病原体阴道球菌的细胞毒素 CptA 在发病机制中的作用”
基本信息
- 批准号:10593631
- 负责人:
- 金额:$ 23.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-11-04 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAmino AcidsAnaerobic BacteriaAnimalsAntibodiesAntibody ResponseBacteremiaBindingBiological ModelsBiologyBlood specimenClinical MicrobiologyCulture-independent methodsCytotoxinDNADataDegenerative polyarthritisDetectionDevelopmentEndometritisEnzyme-Linked Immunosorbent AssayEpithelial CellsEtiologyExhibitsFemaleFetal DeathFetal MembranesGenesGoalsHealthy People 2020HistophilusHumanImmuneImmune responseImmunoglobulin AImmunoglobulin GImmunoglobulin MIn VitroInbred BALB C MiceIncidenceInfectionInvadedMeasurementMediatingMembraneMeningitisMethodsModelingMothersMusNamesNaturePathogenesisPeripheralPhylogenetic AnalysisPilot ProjectsPlacentaPlasmaPlayPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProteinsRecombinantsRoleRouteRuptureSamplingSepsisSerumSpecimenSurfaceSurveysSwabTerm BirthTestingTimeToxinUmbilical Cord BloodUnited States National Institutes of HealthUrethritisUterine cavityUterusVaginaVirulence Factorsdesignemerging pathogenfetalhuman subjectin vivoinfant deathinfant morbidity/mortalitymicrobiome researchmouse modelmutantneonatal morbidityneonatenovelpathogenpathogenic bacteriapregnantpreterm premature rupture of membranesreceptorreproductive tracttrophoblastvaginal microbiota
项目摘要
PROJECT SUMMARY:
Sneathia vaginalis (Sv) is emerging as a pathogen that is significantly associated with preterm birth and can
cause numerous infections including amnionitis, osteoarthritis, meningitis, bacteremia, and urethritis. Due to its
fastidious nature, it has only recently been recognized as a pathogen through the use of DNA-based methods.
Because it has been under-recognized as a pathogen, the biology and the pathogenesis of S. vaginalis remain
almost entirely uncharacterized. We have identified a hemolytic and cytopathogenic toxin produced by S.
vaginalis that we have named CptA. Antiserum against CptA abrogates traversal of Sv across intact human fetal
membranes suggesting that the toxin plays a role in pathogenesis. This project has three main goals. The first
is to assess the maternal and fetal antibody response to CptA during natural colonization/infection. The second
is to establish the role of CptA in traversal of and damage to fetal membranes by Sv. The third is to determine
whether the association between Sv and preterm birth is causal by developing a mouse model of Sv infection
during pregnancy. pathogenesis Characterization of this novel pore-forming toxin will break ground in our
understanding of this emerging pathogen.
项目总结:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KIMBERLY Kay JEFFERSON其他文献
KIMBERLY Kay JEFFERSON的其他文献
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{{ truncateString('KIMBERLY Kay JEFFERSON', 18)}}的其他基金
The Virulome of Infectious Preterm Birth (Project 2; PI: Jefferson)
传染性早产的病毒组(项目 2;负责人:Jefferson)
- 批准号:
8655803 - 财政年份:2014
- 资助金额:
$ 23.29万 - 项目类别:
The Virulome of Infectious Preterm Birth (Project 2; PI: Jefferson)
传染性早产的病毒组(项目 2;负责人:Jefferson)
- 批准号:
8354916 - 财政年份:2012
- 资助金额:
$ 23.29万 - 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
- 批准号:
8147498 - 财政年份:2010
- 资助金额:
$ 23.29万 - 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
- 批准号:
7391713 - 财政年份:2007
- 资助金额:
$ 23.29万 - 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
- 批准号:
7796865 - 财政年份:2007
- 资助金额:
$ 23.29万 - 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
- 批准号:
7599211 - 财政年份:2007
- 资助金额:
$ 23.29万 - 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
- 批准号:
7210257 - 财政年份:2007
- 资助金额:
$ 23.29万 - 项目类别:
Post-transcriptional regulation of biofilm formation S. aureus
生物膜形成的转录后调控金黄色葡萄球菌
- 批准号:
8038279 - 财政年份:2007
- 资助金额:
$ 23.29万 - 项目类别:
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