BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10594002
• 负责人: Gayatri Vedantam
• 金额: --
• 依托单位: SOUTHERN ARIZONA VA HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594002
• 关键词: Active Listening; Address; Age; Animal Model; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics; Arizona; Australia; Award; Bacillus; Bacteria; Bacterial Infections; Basic Science; Biological Response Modifier Therapy; Book Chapters; Canada; Carbohydrates; Categories; Cells; Cellular biology; Clinical; Clostridium difficile; Collaborations; Communicable Diseases; Communication; Communities; Disclosure; Disease; Elderly; Eligibility Determination; Epidemic; Epidemiology; Escherichia coli EHEC; Faculty; Feedback; Fingerprint; First Generation College Students; Fostering; Funding; Genetic; Genomic Islands; Genomics; Goals; Health; Healthcare; Healthcare Systems; Hospitalization; Hospitals; Human; Illinois; Immunocompromised Host; Incidence; Infection; Intellectual Property; Intercellular Junctions; International; Intervention; Intestines; Investigation; Knowledge; Laboratories; Legal patent; Medical; Medical Students; Medical center; Mentors; Mentorship; Methods; Microbial Biofilms; Microscopy; Molecular; Monograph; Nature; Oral; Organism; Paper; Paris, France; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Peer Review; Physicians; Population; Positioning Attribute; Postdoctoral Fellow; Preclinical Testing; Predisposition; Prevalence; Probiotics; Production; Program Development; Proteomics; Publications; Published Comment; Recombinants; Reporting; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Science; Scientist; Seminal; Services; Students; Techniques; Technology; Textbooks; Toxin; Training; Translational Research; Underrepresented Minority; Universities; Veterans; Virulence; Vision; Work; acute care; antibiotic-associated diarrhea; antimicrobial; biobank; capsule; career; comorbidity; cost effective; design; diarrheal disease; doctoral student; early-career faculty; frontier; healthcare-associated infections; improved; infection rate; interdisciplinary collaboration; invention; member; military health system; military veteran; mortality; novel; pathogen; pre-clinical; product development; programs; prospective; recruit; synthetic biology; systems research; tool; ultra high resolution; undergraduate student; vaccine candidate

Current Research and Intellectual Property advancement in the laboratory focuses on bacterial infections that result (paradoxically) from the use of antibiotics. Our studies are performed under a One Health strategy that aims to expand interdisciplinary collaboration in diverse aspects of healthcare for humans and other animals. Our VA and University Affiliate teams are thus focused on elucidating pathogenic mechanisms in the anaerobic human and veterinary pathogen Clostridioides difficile, as well as the diarrheal disease organisms Enteropathogenic and Enterohemorrhagic E. coli. Ongoing studies include comprehensive epidemiological and mechanistic interrogation of C. difficile infection (CDI). Specifically, we have (1) prospective CDI surveillance in Southern Arizona VA and non-VA hospitals that has resulted in one of the only curated, fingerprinted and fully- cataloged C. difficile biorepositories in the Southwestern US; (2) developed precision genomics and proteomics approaches to identify factors contributing to the heightened virulence of newer strains of C. difficile; and (3) leveraged the information from (1) and (2) to develop multiple, novel C. difficile anti-infectives including targeted and bio-controlled live biotherapeutics as well as narrow-spectrum antimicrobials. Our VA Merit awards have resulted in one issued, and two Provisional, Patents as of December 2020. There are two over-arching goals of the activities described above. The first is to improve the health of Veterans and, indeed, the elderly and immunocompromised, by developing safe, oral, cost-effective anti-infective technologies that can transition expediently from the pre-clinical pipeline and into the community. The second is to continue to partner with VA, national and international Collaborators and train mentees such that current efforts can be channeled into a legacy plan for anti-infective research both at the SAVAHCS station as well as the University Affiliate. This renewal RCS application is thus envisaged as critical to the continued building of relationships within and outside the Southern Arizona VA Healthcare System community. Our research record underscores the power of cross-disciplinary science, and the RCS platform has enabled engagement with diverse research groups and fostered new avenues of investigation. Core values that have been cultivated via these collaborations include active listening, inclusive discussion and thoughtful communication. Training and Mentoring is an integral aspect of the PIs’ professional vision, and the current RCS cycle has provided opportunities to work with diverse and outstanding trainees and mentees. These have included (and continue to include) first-generation college students, members of under-represented minorities, early-career Faculty, and Physician-Scientist trainees. Taken together, RCS activities are envisioned to continue fostering focused and substantive contributions to the betterment of Veterans’ health via the development of products and technologies aimed at ameliorating healthcare-associated infections.

实验室中当前的研究和知识产权进步着重于细菌感染 抗生素的使用（自相矛盾的是）。我们的研究是根据一种健康策略进行的 旨在扩大针对人类和其他动物的医疗保健潜水员方面的跨学科合作。 因此，我们的VA和大学分支机构团队专注于阐明厌氧中的致病机制 人类和兽医病原体梭菌艰难梭菌以及腹泻病生物 肠病毒和肠肠肠肠肠球大肠杆菌。正在进行的研究包括全面的流行病学和 艰难梭菌感染（CDI）的机械询问。具体而言，我们有（1）中的CDI监视 亚利桑那州南部弗吉尼亚州和非VA医院，导致了唯一的精选，指纹且完全完整的医院之一 在美国西南部，艰难梭菌的生物库分类； （2）开发了精确的基因组学和蛋白质组学 识别导致艰难梭菌菌株新病毒升高的因素的方法； （3） 利用（1）和（2）的信息发展多种新型艰难梭菌抗感染物，包括有针对性的 和生物控制的活生物治疗剂以及狭窄的抗菌素。我们的VA功绩奖有 截至2020年12月，已发行了一项和两项临时专利。 上述活动有两个超大目标。首先是改善退伍军人的健康 实际上，通过开发安全，口头，具有成本效益的反感性，古老和免疫功能低下 可以极大地从临床前管道转移到社区的技术。第二个是 继续与VA，国家和国际合作者和培训月经合作，以便当前的努力 可以将其引入Savahcs站的遗产计划，以进行反感染研究 大学会员。 因此，该更新的RCS应用程序被认为对于继续建立内部关系和 在亚利桑那州南部VA医疗保健系统社区之外。我们的研究记录强调了 跨学科科学以及RCS平台已使参与潜水员研究小组和 建立了新的投资途径。通过这些合作培养的核心价值包括 积极的聆听，包容性的讨论和周到的沟通。 培训和指导是PIS专业愿景的组成部分，当前的RCS周期已有 提供了与潜水员以及杰出的学员和月经合作的机会。这些包括（以及 继续包括）第一代大学生，代表性不足的少数民族，早期职业人士的成员 教师和医师科学家学员。 综上 通过开发旨在改善产品和技术来改善退伍军人的健康 与医疗保健相关的感染。