Evolution of Phenotypic Extremes and Mechanisms Governing Inheritance
表型极端的进化和遗传控制机制
基本信息
- 批准号:10593140
- 负责人:
- 金额:$ 97.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressBody SizeCell physiologyCellsComplexCongenic StrainCongenital AbnormalityDefectEnsureEnvironmentEvolutionExploratory BehaviorFemaleGenesGeneticGenetic Crossing OverGenetic DeterminismGenetic ModelsGenetic RecombinationGenetic VariationGenomeGenomicsGigantismHouse miceIndividualIslandLaboratoriesLaboratory miceMeiosisMetabolic syndromeMethodsMusMutationOrganismPhenotypePopulationPositioning AttributeProcessResearchResolutionSystemVarianthuman diseaseinterestmalemodel organismnervous system disordernoveloffspringprogramssegregationsextraitwhole genome
项目摘要
PROJECT SUMMARY
We propose a research program in evolutionary genetics and genomics that emphasizes two distinct themes.
The first theme focuses on the island rule – the widespread phenomenon of populations evolving unusual body
sizes after colonizing islands. Advances in our laboratory have established mice from Gough Island, the largest
wild house mice in the world, as a tractable system for understanding genetic mechanisms responsible for the
evolution of extreme body size. Through comprehensive characterization of novel congenic strains, we will
identify genes and mutations involved in this instance of the island rule. To elucidate causes and
consequences of gigantism, we will extend this unique system to genetically dissect another trait associated
with evolution on islands: exploratory behavior. This research direction will reveal genetic principles of complex
trait evolution in novel environments.
The second theme centers on recombination, a process that diversifies offspring genomes and ensures proper
chromosomal segregation during meiosis in many species. Using single-cell methods that enable us to quantify
recombination in individuals, we have discovered that house mice evolved substantial differences in genomic
crossover number over short timescales, with females and males showing discordant trajectories. Motivated by
this advance, we will reconstruct the evolutionary dynamics of the recombination landscape in house mice
across genomic scales (from hotspots to whole genomes) and temporal scales (from thousands to millions of
years). To identify cellular processes involved in the evolution of recombination, we will integrate high-
resolution, sex-specific positioning of crossovers with cellular profiling of key meiotic phenotypes. This
research direction will unveil mechanisms that drive the evolution of a primary determinant of genetic variation.
These distinct themes of research showcase a program that exploits the power of genetics and genomics in
house mice to address fundamental evolutionary questions with breadth and depth. Beyond their evolutionary
significance, the traits of interest are connected to common human diseases. Defects in recombination are the
leading genetic cause of birth defects, body size is related to the metabolic syndrome, and exploratory activity
is associated with neurological disorders. Our research offers potential to illuminate these conditions by
deciphering natural variation in the premier genetic model organism for human disease.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bret A Payseur其他文献
Bret A Payseur的其他文献
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{{ truncateString('Bret A Payseur', 18)}}的其他基金
Evolution of Phenotypic Extremes and Mechanisms Governing Inheritance
表型极端的进化和遗传控制机制
- 批准号:
10084060 - 财政年份:2021
- 资助金额:
$ 97.11万 - 项目类别:
Evolution of Phenotypic Extremes and Mechanisms Governing Inheritance
表型极端的进化和遗传控制机制
- 批准号:
10375351 - 财政年份:2021
- 资助金额:
$ 97.11万 - 项目类别:
Evolution of the Genome-wide Recombination Rate in Mice
小鼠全基因组重组率的演变
- 批准号:
9896869 - 财政年份:2017
- 资助金额:
$ 97.11万 - 项目类别:
The Genetics and Evolution of Extreme Body Size in Mice from Gough Island
戈夫岛小鼠极端体型的遗传学和进化
- 批准号:
8541868 - 财政年份:2012
- 资助金额:
$ 97.11万 - 项目类别:
The Genetics and Evolution of Extreme Body Size in Mice from Gough Island
戈夫岛小鼠极端体型的遗传学和进化
- 批准号:
8370621 - 财政年份:2012
- 资助金额:
$ 97.11万 - 项目类别:
The Genetics and Evolution of Extreme Body Size in Mice from Gough Island
戈夫岛小鼠极端体型的遗传学和进化
- 批准号:
8675265 - 财政年份:2012
- 资助金额:
$ 97.11万 - 项目类别:
Integrating SNPs and STRPs in Population Genetics
将 SNP 和 STRP 整合到群体遗传学中
- 批准号:
7906032 - 财政年份:2008
- 资助金额:
$ 97.11万 - 项目类别:
Integrating SNPs and STRPs in Population Genetics
将 SNP 和 STRP 整合到群体遗传学中
- 批准号:
7674019 - 财政年份:2008
- 资助金额:
$ 97.11万 - 项目类别:
Integrating SNPs and STRPs in Population Genetics
将 SNP 和 STRP 整合到群体遗传学中
- 批准号:
8118279 - 财政年份:2008
- 资助金额:
$ 97.11万 - 项目类别:
Integrating SNPs and STRPs in Population Genetics
将 SNP 和 STRP 整合到群体遗传学中
- 批准号:
7523320 - 财政年份:2008
- 资助金额:
$ 97.11万 - 项目类别:
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