Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity

图像引导肥胖动脉栓塞术 (BAE) 治疗肥胖症

基本信息

  • 批准号:
    10593586
  • 负责人:
  • 金额:
    $ 69.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-05-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

Over 40% of Americans are obese, with the prevalence of obesity continuing to rise. Obesity negatively affects general health and has been attributed to an increasing incidence of diabetes, heart disease, vascular disease, joint stress, lumbar spine disorders, liver and biliary disease, and various cancers. In the prior granting period, we developed a minimally invasive, image-guided, percutaneous intervention called bariatric arterial embolism (BAE), which was tested in growing swine and translated to a Phase I clinical trial in patients, and was shown to decrease weight gain in growing pigs based on embolic size and target location and safely cause weight loss in people. While surgical approaches have shown better reductions in weight than BAE, they are highly invasive (requiring reconstruction of bowel), have variable success rates, and can have significant complications. Thus, in this renewal application, we seek to refine and develop alternative strategies for minimally invasive BAE and weight reduction. Using a novel microfluidic device to create high-throughput radiopaque embolics and an anti-reflux catheter, we performed BAE in growing swine and demonstrated the effects of BAE on gastric hormones, i.e., ghrelin, gastrin, GLP-1, etc. with smaller embolics being more effective at reducing weight gain. However, smaller embolics are also associated with increased the risk of severe adverse events including gastric perforation. Ghrelin, the primary hunger hormone, which is produced primarily in the gastric fundus, remains a major target for weight reduction. As BAE would be performed in otherwise healthy patients, the risk of non- target embolization (NTE) to organs that share the same vascular supply as the stomach, such as the liver, spleen, pancreas, remains a concern as well. Thus, critical issues such as improved targeting, safety, and long- term efficacy need to be further addressed in order to translate this procedure from animals into patients as a durable treatment for obesity. In this proposal, we seek to improve the safety of BAE using radiolabeled embolics as well as test two new concepts for minimally invasive, image-guided weight loss. We will test these techniques in obese dogs rather than growing pigs as a more realistic model of obesity in people. Our Specific Aims include: 1) Evaluate the safety and efficacy of Yttrium-90 labeled embolics for BAE; 2) Evaluate microencapsulated, iron-oxide nanoparticle (MIONPs) combined with magnetic hyperthermia (MHT) for weight loss; and 3) Develop MR-guided vagal cryoablation as a weight-loss strategy to determine long-term minimally invasive techniques for treating obesity.
超过40%的美国人肥胖,肥胖的患病率继续上升。肥胖消极 影响一般健康,并已归因于糖尿病、心脏病、血管性疾病、 疾病、关节压力、腰椎疾病、肝脏和胆道疾病以及各种癌症。在先前授予 在此期间,我们开发了一种微创,图像引导,经皮介入治疗,称为肥胖动脉 栓塞(BAE),这是在生长的猪进行测试,并转化为患者的I期临床试验, 根据栓塞尺寸和靶位置,显示可降低生长猪的体重增加, 人的体重减轻。虽然手术方法显示出比BAE更好的减肥效果,但它们 高度侵入性(需要肠重建),有不同的成功率,并可能具有显著的 并发症因此,在此更新申请中,我们寻求优化和开发替代策略, 侵入性BAE和减肥 使用新型微流体装置来产生高通量不透射线栓塞剂和抗反流剂 导管,我们在生长猪中进行了BAE,并证明了BAE对胃激素的影响,即, 胃饥饿素、胃泌素、GLP-1等,其中较小的栓塞剂在减少体重增加方面更有效。然而,在这方面, 较小的栓塞也与严重不良事件的风险增加有关, 穿孔胃饥饿素是主要的饥饿激素,主要在胃底产生, 减肥的主要目标。由于BAE将在其他方面健康的患者中进行, 靶向栓塞(NTE)到与胃共享相同血管供应的器官,如肝脏, 脾脏胰腺也是个问题因此,关键问题,如改进的靶向,安全性和长期- 为了将该方法从动物转化为患者, 肥胖症的持久治疗。 在这个建议中,我们试图提高使用放射性标记栓塞剂的BAE的安全性,以及试验二 微创、影像引导减肥的新概念。我们将在肥胖狗身上测试这些技术 而不是把养猪作为人类肥胖的更现实的模型。我们的具体目标包括:1)评估 钇-90标记栓塞剂治疗BAE的安全性和有效性; 2)评价微囊化氧化铁 纳米粒子(MIONP)结合磁热疗(MHT)用于减肥;以及3)开发MR引导的 迷走神经冷冻消融术作为一种减肥策略,以确定长期微创技术治疗 肥胖

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DARA L KRAITCHMAN其他文献

DARA L KRAITCHMAN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DARA L KRAITCHMAN', 18)}}的其他基金

MR-compatible Devices for the Diagnosis and Treatment of Cardiomyopathies
用于诊断和治疗心肌病的 MR 兼容设备
  • 批准号:
    10198263
  • 财政年份:
    2021
  • 资助金额:
    $ 69.1万
  • 项目类别:
MR-compatible Devices for the Diagnosis and Treatment of Cardiomyopathies
用于诊断和治疗心肌病的 MR 兼容设备
  • 批准号:
    10471268
  • 财政年份:
    2021
  • 资助金额:
    $ 69.1万
  • 项目类别:
MR-compatible Devices for the Diagnosis and Treatment of Cardiomyopathies
用于诊断和治疗心肌病的 MR 兼容设备
  • 批准号:
    10671041
  • 财政年份:
    2021
  • 资助金额:
    $ 69.1万
  • 项目类别:
MRI-Guided Cryoablation and Imaging-Guided Intratumoral Delivery of STING Agonist Immunotherapy to Target Localized and Metastatic Canine Osteosarcoma
MRI 引导冷冻消融和成像引导 STING 激动剂肿瘤内递送免疫疗法治疗局部和转移性犬骨肉瘤
  • 批准号:
    10375449
  • 财政年份:
    2020
  • 资助金额:
    $ 69.1万
  • 项目类别:
MRI-Guided Cryoablation and Imaging-Guided Intratumoral Delivery of STING Agonist Immunotherapy to Target Localized and Metastatic Canine Osteosarcoma
MRI 引导冷冻消融和成像引导 STING 激动剂肿瘤内递送免疫疗法治疗局部和转移性犬骨肉瘤
  • 批准号:
    10633064
  • 财政年份:
    2020
  • 资助金额:
    $ 69.1万
  • 项目类别:
MRI-Guided Cryoablation and Imaging-Guided Intratumoral Delivery of STING Agonist Immunotherapy to Target Localized and Metastatic Canine Osteosarcoma
MRI 引导冷冻消融和成像引导 STING 激动剂肿瘤内递送免疫疗法治疗局部和转移性犬骨肉瘤
  • 批准号:
    9980073
  • 财政年份:
    2020
  • 资助金额:
    $ 69.1万
  • 项目类别:
Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
图像引导肥胖动脉栓塞术 (BAE) 治疗肥胖症
  • 批准号:
    8840587
  • 财政年份:
    2013
  • 资助金额:
    $ 69.1万
  • 项目类别:
Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
图像引导肥胖动脉栓塞术 (BAE) 治疗肥胖症
  • 批准号:
    8420946
  • 财政年份:
    2013
  • 资助金额:
    $ 69.1万
  • 项目类别:
Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
图像引导肥胖动脉栓塞术 (BAE) 治疗肥胖症
  • 批准号:
    9061405
  • 财政年份:
    2013
  • 资助金额:
    $ 69.1万
  • 项目类别:
Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
图像引导肥胖动脉栓塞术 (BAE) 治疗肥胖症
  • 批准号:
    8651916
  • 财政年份:
    2013
  • 资助金额:
    $ 69.1万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 69.1万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了